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Iron oxide nanoparticles are synthesized by co-precipitation, converted into oil-in-water nano-emulsions, and characterized. Five groups of Syrian hamsters receive negative control, DMBA-painted positive control, quercetin dosing, or nano-emulsion treatments with staged DMBA exposure. Biochemical, histopathological, and immunohistochemical results show improved blood parameters and reduced tumor markers, with a pronounced protective effect against oral squamous cell carcinoma and modulation of Ki-67 and Bcl-2.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synthesis-of-a-nano-emulsion-of-quercetin-encapsulated-vitamin-e-conjugated-iron-oxide-nanoparticles-for-the-systemic-phyto-preventive-eect-characterization-and-oral-cancer-application/438545/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synthesis-of-a-nano-emulsion-of-quercetin-encapsulated-vitamin-e-conjugated-iron-oxide-nanoparticles-for-the-systemic-phyto-preventive-eect-characterization-and-oral-cancer-application/438545.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of the study?","Question",{"text":112,"@type":113},"To counter the carcinogenic effect of DMBA in hamsters using nano-emulsions of quercetin encapsulated with vitamin E and iron oxide, and to evaluate their oral cancer application.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the iron oxide nanoparticles and nano-emulsions prepared?",{"text":117,"@type":113},"Iron oxide nanoparticles were prepared by co-precipitation, converted into nano-emulsions using an oil-in-water technique, and then characterized.",{"name":119,"@type":110,"acceptedAnswer":120},"What biochemical and tissue outcomes were observed with nano-emulsion treatment?",{"text":121,"@type":113},"Nano-emulsion treated animals showed significant improvements in multiple biochemical parameters and histopathological changes consistent with reduced carcinogenic progression, alongside altered Ki-67 and Bcl-2 expression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},438545,1790764855,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Nanoscale Advances  \nPAPER  \nCite this: DOI: 10 .1039/d5na00546a  \nReceived 3rd June 2025  \nAccepted 29th October 2025 DOI: 10.1039/d5na00546a[rsc.li/nanoscale-advances](rsc.li/nanoscale-advances)  \nSynthesis of a nano-emulsion of quercetin encapsulated vitamin E conjugated iron oxide nanoparticles for the systemic phyto-preventive eﬀect: characterization and oral cancer application  \nMerhan N. El-Mansy,a Zeyad M. Hamdy,b Ahmed E. Abdelsamiebc and Ola M. ElBorady  *d  \nBackground: Globally, one of the most pressing public health concerns is the prevention of oral cancerous lesions. This study aimed to reverse the carcinogenic eﬀect of DMBA in hamsters by using nano-emulsions of quercetin encapsulated vitamin E and iron oxide. Methods: The studied iron oxide nanoparticles were prepared by the co-precipitation method and then converted into nano-emulsions via the oil-in-water technique and characterized. The study included ﬁve equal groups of 30 Syrian male hamsters aged eight weeks. Group A constituted a negative control, and Group B received 25 mg kg−1 of nanoemulsion orally three times per week for eight weeks. Group C (positive control) was painted with DMBAon the left pouches three times per week for six weeks. Group D received 25 mg kg−1 of quercetin thrice per week for two weeks orally, with a continued painting of DMBA per week for six weeks. Group E received 25 mg kg−1 of nano-emulsion orally, three times per week, for two weeks, and then continued using it with painting DMBA three times per week for six weeks. Results: The morphological and chemical characterization of the synthesized emulsions revealed the formation of spherical particles in the nanoscale emulsion. A signiﬁcant improvement was noted in the nano-emulsion group compared to the DMBA-painted group in multiple biochemical parameters, such as hemoglobin, RBCs, platelets, WBCs, neutrophils, lymphocytes, monocytes, ALT, AST, creatinine, and urea. The histopathological and immunohistochemical assessments revealed well-diﬀerentiated squamous cell carcinoma in the DMBAtreated group, with intense expression of Ki-67 and Bcl-2 . In the quercetin-treated group, superﬁcial invasion of carcinoma in situ was noted with a moderate decrease in the expression of Ki-67 and Bcl-2 . Marked improvement was observed in the quercetin nano-emulsion-treated group that showed moderate to severe dysplasia with an obvious decrease in Ki-67 and Bcl-2 expression. Conclusion: The study results conﬁrmed that the prepared quercetin-vitamin E-Fe3O4 formulations are novel in combining magnetic targeting and antioxidant co-protection nano-emulsions and signiﬁcantly prevented oral squamous cell carcinoma in hamsters.  \n1. Introduction  \nPremalignant lesions lead to changes in the epithelium with higher potential for malignancy. They include hyperplasia andatypia with a low risk of malignant transformation, whereas dysplasia represents a higher malignant potential. Oral  \naFaculty of Dentistry, Suez Canal University, Kilo 4.5 Ring Road., Ismailia, Egypt. [E-mail: merhan_elmansy@dent.suez.edu.eg](E-mail: merhan_elmansy@dent.suez.edu.eg)  \nbFaculty of Biotechnology, October University for Modern Science and Arts (MSA), 6th  \nOctober, Giza, Egypt. E-mail: [ziadhamdy100@hotmail.com](ziadhamdy100@hotmail.com)  \ncFaculty of Biology, Adam Mickiewicz University, Poland. E-mail: Ahmed. [ibrahemm22@gmail.com](ibrahemm22@gmail.com)  \ndInstitute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516, Kafr ElSheikh, Egypt. E-mail: [olachem_elborady@yahoo.com](olachem_elborady@yahoo.com); ola_elborady@nano.kfs. [edu.eg](edu.eg)  \nsquamous cell carcinoma (OSCC) is the most debilitating disease that negatively aﬀects the quality of a patient's life. It is considered the sixth most common disease globally, with 700 000 new cases diagnosed each year.1 Despite the advances in diﬀerent therapeutic modalities, the 5-year survival rate has not changed and remains at about 50% .2 It is considered a mult","cbCaiutzqyE9fP4Q","https://ap.wps.com/l/cbCaiutzqyE9fP4Q","pdf",1439579,12,"English","# Introduction\n## Oral premalignant lesions and OSCC background\n## Hamster buccal pouch model and DMBA induction\n## Chemoprevention concept and quercetin rationale","[{\"question\":\"What is the main goal of the study?\",\"answer\":\"To counter the carcinogenic effect of DMBA in hamsters using nano-emulsions of quercetin encapsulated with vitamin E and iron oxide, and to evaluate their oral cancer application.\"},{\"question\":\"How were the iron oxide nanoparticles and nano-emulsions prepared?\",\"answer\":\"Iron oxide nanoparticles were prepared by co-precipitation, converted into nano-emulsions using an oil-in-water technique, and then characterized.\"},{\"question\":\"What biochemical and tissue outcomes were observed with nano-emulsion treatment?\",\"answer\":\"Nano-emulsion treated animals showed significant improvements in multiple biochemical parameters and histopathological changes consistent with reduced carcinogenic progression, alongside altered Ki-67 and Bcl-2 expression.\"}]","Synthesis of a nano-emulsion of quercetin encapsulated vitamin E conjugated iron oxide nanoparticles for the systemic phyto-preventive eﬀect - characterization and oral cancer application | PDF",1790685672]