[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31842":3,"doc-seo-31842":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31842,13056703019404,"Miles","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0",8,"Research & Report","Synthesis, Molecular Modelling Studies of Artemisinin-Chalcone Derivatives and Their Antimalarial Activity Evaluation","Twenty-two artemisinin monomers and dimers linked via a chalcone linker were synthesized and assessed for antimalarial activity against Plasmodium falciparum, with a quantitative structure–activity relationship (QSAR) developed to relate chemical structure to potency. Artemisinin is a globally used frontline antimalarial but is threatened by rapidly emerging artemisinin-resistant P. falciparum strains. In vitro testing identified dimethoxy chalcone–linked artemisinin dimer (compound 22) as the most active, with IC50 4.34 nM. In silico docking and ADMET studies investigated molecular mechanisms for the active candidates.","cbCairzf6CH75HJz","https://ap.wps.com/l/cbCairzf6CH75HJz","pdf",2368129,1,12,"English","en","# Introduction\n# Background on malaria and artemisinin resistance\n# Chalcones and rationale for artemisinin–chalcone hybrids\n# Study objectives and scope","[{\"question\":\"What compounds were synthesized and how many were evaluated in this study?\",\"answer\":\"The study synthesized 22 artemisinin monomers and dimers with chalcone as a linker, then evaluated their antimalarial activity against Plasmodium falciparum.\"},{\"question\":\"What was the most active compound and its IC50 value?\",\"answer\":\"The most active compound was the artemisinin dimer dimethoxy chalcone linker (22), showing an IC50 of 4.34 nM.\"},{\"question\":\"How were mechanisms and properties of the active compounds explored beyond in vitro testing?\",\"answer\":\"Molecular mechanisms were investigated using in silico docking alongside ADMET studies for the active compounds.\"}]",1780261368,30,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"synthesis-molecular-modelling-studies-of-artemisinin-chalcone-derivatives-and-their-antimalarial-activity-evaluation","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/synthesis-molecular-modelling-studies-of-artemisinin-chalcone-derivatives-and-their-antimalarial-activity-evaluation/31842/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-31",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What compounds were synthesized and how many were evaluated in this study?","Question",{"text":73,"@type":74},"The study synthesized 22 artemisinin monomers and dimers with chalcone as a linker, then evaluated their antimalarial activity against Plasmodium falciparum.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"What was the most active compound and its IC50 value?",{"text":78,"@type":74},"The most active compound was the artemisinin dimer dimethoxy chalcone linker (22), showing an IC50 of 4.34 nM.",{"name":80,"@type":71,"acceptedAnswer":81},"How were mechanisms and properties of the active compounds explored beyond in vitro testing?",{"text":82,"@type":74},"Molecular mechanisms were investigated using in silico docking alongside ADMET studies for the active compounds.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]