[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-410294-105":59,"doc-detail-410294-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","synergistic-therapy-for-osteoporosis-a-soybean-osteogenic-peptide-loaded-fish-gelatin-carrageenan-gel-for-enhanced-bone-regeneration","Synergistic therapy for osteoporosis: a soybean osteogenic peptide-loaded fish gelatin/κ-carrageenan gel for enhanced bone regeneration","","Osteoporosis is a skeletal disorder marked by diminished bone formation and elevated fracture risk. Peptide therapeutics can promote osteogenesis but face instability and rapid clearance. This work develops a dual-network hydrogel carrier of fish gelatin and κ-carrageenan loaded with a soybean-derived osteogenic peptide (SOP). The FG/κ-CG system supports mechanical stability, hydration balance, and thermal reliability, enabling sustained peptide protection and controlled release.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synergistic-therapy-for-osteoporosis-a-soybean-osteogenic-peptide-loaded-fish-gelatin-carrageenan-gel-for-enhanced-bone-regeneration/410294/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synergistic-therapy-for-osteoporosis-a-soybean-osteogenic-peptide-loaded-fish-gelatin-carrageenan-gel-for-enhanced-bone-regeneration/410294.png","ImageObject",300,407,{"name":92,"@type":93},"Rhys","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are peptide therapeutics challenging for osteoporosis treatment?","Question",{"text":112,"@type":113},"They are limited by instability and rapid systemic clearance, and they also face inefficient targeted delivery in vivo.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What hydrogel system was developed in this study?",{"text":117,"@type":113},"A dual-network hydrogel composed of fish gelatin (FG) and κ-carrageenan (κ-CG) loaded with a soybean-derived osteogenic peptide (SOP).",{"name":119,"@type":110,"acceptedAnswer":120},"How was the SOP-loaded gel evaluated for efficacy?",{"text":121,"@type":113},"It was tested in a glucocorticoid-induced zebrafish osteoporosis model, where oral administration restored bone mineralization comparably to alendronate treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},410294,1790814197,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","OPEN ACCESS  \nEDITED BY  \nZhouyi Xiong,  \nDongguan University of Technology, China  \nREVIEWED BY  \nYuanyuan Li,  \nZhejiang Agriculture and Forestry University, China  \nRui Liu,  \nYuncheng University, China Fenghua Liu,  \nChinese Academy of Sciences, China  \n*CORRESPONDENCE  \nJunbo Ge  \n [doctorgjb@163.com](doctorgjb@163.com);  \n [ytsyygjp@163.com](ytsyygjp@163.com)[ ](ytsyygjp@163.com)RECEIVED 30 October 2025 REVISED 21 November 2025 ACCEPTED 27 November 2025 PUBLISHED 18 December 2025  \nCITATION  \nGong J, Zhang Y, Jie T, Huang T, Ma Y, Chen H, Gan J and Ge J (2025) Synergistic therapy for osteoporosis: a soybean osteogenic peptide-loaded fish  \ngelatin/κ-carrageenan gel for enhanced bone regeneration.  \nFront. Nutr. 12:1735717.  \ndoi: 10.3389/fnut.2025.1735717  \nCOPYRIGHT  \n© 2025 Gong, Zhang, Jie, Huang, Ma, Chen, Gan and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTYPE Original Research PUBLISHED 18 December 2025 DOI 10.3389/fnut.2025.1735717  \nSynergistic therapy for osteoporosis: a soybean osteogenic peptide-loaded fish gelatin/κ-carrageenan gel for enhanced bone regeneration  \nJinpeng Gong 1, Yuhan Zhang 2, Tao Jie 2, Tao Huang 1, Yupeng Ma 1, Hao Chen 2, Jing Gan3 and Junbo Ge 1*  \n1Department of Trauma Orthopedics, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, China, 2Marine College, Shandong University, Weihai, Shandong, China, 3College of Life Science, Yantai University, Yantai, Shandong, China  \nOsteoporosis is a widespread skeletal disorder associated with reduced bone formation and increased fracture risk. Peptide-based therapeutics offer demonstrate anabolic potential for osteoporosis management but are limited by instability and rapid clearance. In this study, a dual-network hydrogel composed of fish gelatin (FG) and κ-carrageenan (κ-CG) was developed as a biocompatible carrier fora soybean-derived osteogenic peptide (SOP) . The FG/κ-CG system exhibited provided mechanical integrity, hydration balance, and thermal stability, thereby enabling sustained peptide protection and controlled release. In a glucocorticoidinduced zebrafish osteoporosis model, oral administration of the SOP-loaded gel effectively restored bone mineralization to a level comparable with alendronate treatment. These findings suggest that the FG/κ-CG-SOP hydrogel provides astable and bioactive platform for osteogenic peptide delivery and represents a promising nutritional or therapeutic approach for osteoporosis management.  \nKEYWORDS  \ndual-network gel, fish gelatin, κ-carrageenan, osteoporosis, soybean osteogenic peptide  \n1 Introduction  \nOsteoporosis is a systemic skeletal disorder characterized by decreased bone mass, structural deterioration, and increased fracture susceptibility ( 1–3) . Its pathogenesis mainly arises results from an imbalance between bone resorption and formation (4) . Current therapeutic strategies, including bisphosphonates, hormone therapy, and monoclonal antibodies, can slow bone loss to some degree; however, their long-term efficacy is limited undermined by adverse side effects and considerable variability in patient response (5–7) . These limitations highlight the urgent need for novel therapeutic approaches that directly restore osteogenic capacity within osteoporotic bone tissue.  \nBioactive peptides have recently attracted gained increasing attention as emerging osteoinductive agents (8, 9). Compared with conventional small-molecule drugs and protein growth factors, peptides offer possess well-defined molecular weights, high aqueous solubility, low immunogenicity, and the ability to","cbCaiiU5X6YyTh1r","https://ap.wps.com/l/cbCaiiU5X6YyTh1r","pdf",4692350,14,"English","# Introduction\n## Osteoporosis background and current therapies\n## Osteogenic peptides and SOP rationale\n## Hydrogel carriers: fish gelatin and κ-carrageenan","[{\"question\":\"Why are peptide therapeutics challenging for osteoporosis treatment?\",\"answer\":\"They are limited by instability and rapid systemic clearance, and they also face inefficient targeted delivery in vivo.\"},{\"question\":\"What hydrogel system was developed in this study?\",\"answer\":\"A dual-network hydrogel composed of fish gelatin (FG) and κ-carrageenan (κ-CG) loaded with a soybean-derived osteogenic peptide (SOP).\"},{\"question\":\"How was the SOP-loaded gel evaluated for efficacy?\",\"answer\":\"It was tested in a glucocorticoid-induced zebrafish osteoporosis model, where oral administration restored bone mineralization comparably to alendronate treatment.\"}]","Synergistic therapy for osteoporosis: a soybean osteogenic peptide-loaded fish gelatin/κ-carrageenan gel for enhanced bone regeneration | PDF",1790584894,35]