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Taurine (TAU), an essential beta-amino acid with antioxidant, antimutagenic, and anti-inflammatory properties, may protect tissues from chemotherapy-induced toxicity. This rat study tested whether TAU mitigates the adverse effects of 5-FU by analyzing colon tissues after DMH-induced carcinogenesis and subsequent TAU administration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synergistic-enhancement-of-5-fluorouracil-chemotherapeutic-efficacy-by-taurine-in-colon-cancer-rat-model/331342/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synergistic-enhancement-of-5-fluorouracil-chemotherapeutic-efficacy-by-taurine-in-colon-cancer-rat-model/331342.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address in colorectal cancer treatment?","Question",{"text":112,"@type":113},"The study addresses limitations of current colorectal cancer treatments, including ineffectiveness, toxicity, and resistance associated with 5-fluorouracil.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was colon cancer induced for the rat model?",{"text":117,"@type":113},"Carcinogenesis was chemically induced in rats using 1,2-dimethylhydrazine (DMH), followed by a period of cancer progression.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes were observed when taurine was combined with 5-fluorouracil?",{"text":121,"@type":113},"In the 5-FU + TAU group, no adenocarcinoma was observed, and when associated with taurine the mitotic index and dysplasia levels returned toward normal, suggesting a synergistic anticancer effect.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331342,1790126302,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","nutrients   \nArticle  \nSynergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model  \nDaniela Hartmann Jornada 1, Diogo Boreski 1, Diego Eidy Chiba 1, Denise Ligeiro 2,  \nMarcus Alexandre Mendes Luz 3, Edmo Atique Gabriel 3, Cauê Benito Scarim 1, Cleverton Roberto de Andrade 2 and Chung Man Chin 1,3, *  \nCitation: Jornada, D.H.; Boreski, D.; Chiba, D.E.; Ligeiro, D.; Luz, M.A.M.; Gabriel, E.A.; Scarim, C.B.; de Andrade, C.R.; Chin, C.M. Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model. Nutrients 2024, 16, 3047. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/nu16183047](10.3390/nu16183047)  \nAcademic Editor: Yi-Chia Huang  \nReceived: 13 August 2024  \nRevised: 27 August 2024  \nAccepted: 5 September 2024  \nPublished: 10 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratory for Drug Design (LAPDESF), Drugs and Medicines Department, School of Pharmaceutical Sciences, University of São Paulo State, UNESP, Araraquara 14800-903, SP, Brazil; [daniela.hj@hotmail.com](daniela.hj@hotmail.com) (D.H.J.); [diogo.boreski@unesp.br](diogo.boreski@unesp.br) (D.B.); [diego.chiba@unesp.br](diego.chiba@unesp.br) (D.E.C.); [caue.scarim@unesp.br](caue.scarim@unesp.br) (C.B.S.)  \n2 Physiology and Pathology Department, School of Dentistry, University of São Paulo State, UNESP, Araraquara 14801-385, SP, Brazil; [denise_ligeiro@hotmail.com](denise_ligeiro@hotmail.com) (D.L.); [cleverton.andrade@unesp.br](cleverton.andrade@unesp.br) (C.R.d.A.)  \n3 Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), São José do Rio Preto 15030-070, SP, Brazil; [30397@unilago.edu.br](30397@unilago.edu.br) (M.A.M.L.); [edag@uol.com.br](edag@uol.com.br) (E.A.G.)  \n* Correspondence: [chung.man-chin@unesp.br](chung.man-chin@unesp.br)  \nAbstract: Colorectal cancer (CRC) is one of the top 10 most common cancers worldwide and caused approximately 10 million deaths in 2022 . CRC mortality has increased by 10% since 2020 and 52.000 deaths will occur in 2024, highlighting the limitations of current treatments due to ineffectiveness, toxicity, or non-adherence. The widely used chemotherapeutic agent, 5-fluorouracil (5-FU), is associated with several adverse effects, including renal, cardiac, and hepatic toxicity; mucositis; and resistance. Taurine (TAU), an essential β-amino acid with potent antioxidant, antimutagenic, and anti-inflammatory properties, has demonstrated protective effects against tissue toxicity from chemotherapeutic agents like doxorubicin and cisplatin. Taurine deficiency is linked to aging and cancers such as breast and colon cancer. This study hypothesized that TAU may mitigate the adverse effects of 5-fluorouracil (5-FU) . Carcinogenesis was chemically induced in rats using 1,2-dimethylhydrazine (DMH). Following five months of cancer progression, taurine (100 mg/kg) was administered orally for 8 days, and colon tissues were analyzed. The results showed 80% ofadenocarcinoma (AC) in DMH-induced control animals. Notably, the efficacy of 5-FU showed 70% AC and TAU 50% while, in the 5-FU + TAU group, no adenocarcinoma was observed. No differences were observed in the inflammatory infiltrate or the expression of genes such as K-ras, p53, and Ki-67 among the cancer-induced groups whereas APC/β-catenin expression was increased in the 5FU + TAU-treated group. The mitotic index and dysplasia were increased in the induced 5-FU group and when associated with TAU, the levels returned to normal. These data suggest that 5-FU exhibits a synergic anticancer effect when ","cbCaihAJsimqjdXb","https://ap.wps.com/l/cbCaihAJsimqjdXb","pdf",7385768,"English","# Abstract\n# Introduction\n# Taurine Background","[{\"question\":\"What problem does the study address in colorectal cancer treatment?\",\"answer\":\"The study addresses limitations of current colorectal cancer treatments, including ineffectiveness, toxicity, and resistance associated with 5-fluorouracil.\"},{\"question\":\"How was colon cancer induced for the rat model?\",\"answer\":\"Carcinogenesis was chemically induced in rats using 1,2-dimethylhydrazine (DMH), followed by a period of cancer progression.\"},{\"question\":\"What outcomes were observed when taurine was combined with 5-fluorouracil?\",\"answer\":\"In the 5-FU + TAU group, no adenocarcinoma was observed, and when associated with taurine the mitotic index and dysplasia levels returned toward normal, suggesting a synergistic anticancer effect.\"}]","Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model | PDF",1789992744]