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Biocompatible piezoelectric nanoparticles act as piezocatalysts to generate reactive oxygen species (ROS) and disrupt biological processes. 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\n[www.advancedscience.com](www.advancedscience.com)  \nSynergistic Anti-Cancer Therapy Through Ultrasound-Induced Piezocatalytic Therapy and Tumor Treatment Fields  \nJing Jin, Haoyue Xue, Keliang Chen, Yonglin Su, Xin Hu, Xiaolin Hu, Xing Huang, Laiming Jiang,* Jiagang Wu,* and Xingchen Peng*  \nThe integration of therapeutic modalities to enhance cancer treatment efficacyand improve patient outcomes offers remarkable benefits over monotherapies and has attracted considerable attention. Herein, a synergistic anti-cancer therapy leveraging the benefits of physical tumor treating fields (TTFs) and dynamic piezocatalytic therapy (PCT) is presented, aiming to offer an optimized scheme while minimizing systemic side effects. First, a wearable ultrasound-induced wireless energy harvester based on biocompatible  \nlead-free potassium sodium niobate-based piezocomposites is developed to enable efficient acoustic-to-electric conversion. The flexible printed circuit board architecture with two pairs of half-ring electrodes not only generates wide-anging alternating electric fields but also facilitates easy fixation and wearability. Second, biocompatible piezoelectric nanoparticles (NPs) serve asthe piezocatalysts to promote the generation of reactive oxygen species (ROS) and to directly interfere with biological processes. Finally, in vivo evaluations using mouse models demonstrate that the combination of  \nultrasound-activated PCT and TTFs significantly inhibits tumor growth and modulates the tumor immune microenvironment. Notably, prominent synergistic antitumor effects are also observed in patient-derived xenograft (PDX) models of head and neck squamous cell carcinoma (HNSCC), highlighting a versatile approach to advance cancer treatment.  \n1. Introduction  \nCancer is a multifaceted global health challenge. [1] Cancer therapy has witnessed significant advancements with the emerging treatment modalities aimed at enhancing efficacy. Among these, tumor treatment fields (TTFs) therapy represents a promising approach, featuring non-invasive, low toxicity, favorable efficacy, and highly sensitivity, which interferes with the mitotic mechanism of tumor cells by applying low-intensity alternating electric fields, thereby inhibiting cell division and promoting apoptosis. [2–4] TTFs has been approved by the Food and Drug Administration (FDA) for various solid tumors, including glioblastoma multiforme (GBM), where it has demonstrated efficacy in extending progression-free survival (PFS)and overall survival (OS) . [2,5,6] Clinical trials for other localized solid tumors are ongoing, such as non-small-cell lung cancer and pancreatic adenocarcinoma. [5–8] However, its local therapeutic efficacy depends on the precise placement of electrodes, potentially limiting its applicability  \nJ. Jin, K. Chen, X. Hu, X. Peng Department of Biotherapy Cancer Center  \nWest China Hospital Sichuan University Chengdu 610041, China  \nE-mail: [pxx2014@scu.edu.cn](pxx2014@scu.edu.cn)  \nJ. Jin  \nDepartment of Obstetricsand Gynecology  \nWest China Second University Hospital of Sichuan University Chengdu, Sichuan 610041, China  \nThe ORCID identification number(s) for the author(s) of this article  \ncan be found under [https://doi.org/10.1002/advs.202511604](https://doi.org/10.1002/advs.202511604)[ ](https://doi.org/10.1002/advs.202511604)© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nDOI: 10.1002/advs.202511604  \nJ. Jin, K. Chen, X. Hu, X. Peng  \nSichuan Provincial Key Laboratory of Nuclear Physics and Medical Research  \nSichuan University Chengdu 610041, China  \nH. Xue, X. Huang, L. Jiang, J. Wu  \nCollege of Materials Science and Engineering Sichuan University  \nChengdu 610064, China  \nE-mail: [laimingjiang@scu.edu.cn](laimingjiang@scu.edu.cn); [msewujg@scu.edu","cbCaijoRF7DBoNFG","https://ap.wps.com/l/cbCaijoRF7DBoNFG","pdf",4242334,15,"English","# Introduction\n## Tumor treatment fields (TTFs)\n## Challenges and need for integration\n## Piezocatalytic therapy (PCT) and ultrasound activation","[{\"question\":\"What is the core strategy behind this synergistic therapy?\",\"answer\":\"The approach integrates tumor treating fields (TTFs) with ultrasound-induced piezocatalytic therapy (PCT) to improve anti-cancer efficacy while limiting systemic side effects.\"},{\"question\":\"How does the ultrasound-induced energy harvester work in the design?\",\"answer\":\"A wearable wireless energy harvester based on biocompatible lead-free piezocomposites converts acoustic energy into electricity, enabling generation of alternating electric fields.\"},{\"question\":\"What evidence supports the therapy’s effectiveness?\",\"answer\":\"In vivo mouse models show significant inhibition of tumor growth and modulation of the tumor immune microenvironment, and patient-derived xenograft (PDX) models of HNSCC also exhibit prominent synergistic antitumor effects.\"}]","Synergistic Anti-Cancer Therapy Through Ultrasound-Induced Piezocatalytic Therapy and Tumor Treatment Fields | PDF",1790775786,38]