[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-371331-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-371331-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","synchronous-occurrence-of-primary-gastric-and-liver-cancer-a-case-report","Synchronous occurrence of primary gastric and liver cancer - A case report","","Primary gastric and liver cancers are among the most prevalent digestive-tract malignancies, yet their global age-standardized incidence remains relatively low at about 11.1 per 100,000 for primary gastric cancer and about 8.657 per 100,000 for primary liver cancer. Although multiple primary malignancies are not rare, synchronous primary gastric and liver cancer is exceedingly uncommon. The report presents a 60-year-old man diagnosed with both conditions, treated with endoscopic submucosal dissection and laparoscopic liver resection. Pathology confirmed moderately differentiated intramucosal adenocarcinoma and well-differentiated hepatocellular carcinoma, with no recurrence after 3 years, emphasizing careful evaluation of distinct lesions and determination of tumor primacy to guide treatment.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/synchronous-occurrence-of-primary-gastric-and-liver-cancer-a-case-report/371331/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/synchronous-occurrence-of-primary-gastric-and-liver-cancer-a-case-report/371331.png","ImageObject",300,407,{"name":42,"@type":43},"Levi","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are synchronous primary gastric and liver cancers considered rare?","Question",{"text":63,"@type":64},"Multiple primary malignancies can occur clinically, but reports of synchronous primary gastric and liver cancer are exceedingly rare.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What treatments were performed for the patient in the case report?",{"text":68,"@type":64},"The patient underwent endoscopic submucosal dissection for gastric lesions and laparoscopic resection of a small liver tumor.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the pathology show and what was the follow-up outcome?",{"text":72,"@type":64},"Pathology revealed moderately differentiated intramucosal adenocarcinoma in the stomach and well-differentiated hepatocellular carcinoma in the liver. After 3 years, the patient remained healthy with no evidence of recurrence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},371331,1790216261,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","ONCOLOGY LETTERS 29: 222, 2025  \nSynchronous occurrence of primary gastric and liver cancer:  \nA case report  \nXIAOMIN ZHANG and XIAOYING HAN  \nDepartment of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science,  \nXiangyang, Hubei 441021, P.R. China  \nReceived June 28, 2024; Accepted October 2, 2024  \nDOI: 10. 3892/ol.2025.14968  \nAbstract. Primary gastric and liver cancers rank among the most prevalent malignant tumors of the digestive tract. Despite their serious implications for health, the global age‑standardized incidence remains relatively low, at ~11.1 per 100,000 for primary gastric cancer and ~8.657 per 100,000 for primary liver cancer. Although the occurrence of multiple primary malignancies is not uncommon in clinical practice, reports of synchronous primary gastric and liver cancer are exceedingly rare. The present study describes a case involving a 60‑year‑old man diagnosed with synchronous primary gastric and liver cancer. The patient underwent endoscopic submucosal dissection for lesions located at the gastric angle, followed by laparoscopic resection of a small liver tumor. Pathological examinations revealed moderately differenti‑ ated intramucosal adenocarcinoma at the gastric angle and well‑differentiated hepatocellular carcinoma in the liver. Following a 3‑year follow‑up, the patient remained in good health, with no evidence of disease recurrence. In conclu‑ sion, clinicians should exercise caution in patients presenting with distinct lesions to ensure that subtle malignancies are not overlooked, particularly in those with confirmed cancer. For patients with multiple cancers, it is crucial to ascertain whether the malignancies are primary, as this determination influences treatment strategies.  \nIntroduction  \nGastric cancer is a prevalent malignancy associated with a high mortality rate, which poses a significant threat to human health. Despite a declining trend in incidence over recent decades, gastric cancer remains the fifth most common cancer and the fourth leading cause of cancer‑related death  \nCorrespondence to: Dr Xiaoying Han, Department of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, 136 Jingzhou Street, Xiangcheng, Xiangyang, Hubei 441021, P.R. China  \nE‑mail: [applexm@sina.com](applexm@sina.com)  \nKey words: synchronous tumors, gastric cancer, liver cancer  \nworldwide (1) . In China, gastric cancer ranks third in both incidence and mortality among all types of cancer, with an estimated global age‑standardized incidence rate of 11.1 per 100,000 (2) . Systemic treatments, including radical surgery, endoscopic resection, chemotherapy, targeted therapy and immunotherapy, have notably evolved, allowing clinicians to tailor therapeutic strategies based on individual disease conditions (1,3) .  \nPrimary liver cancer, encompassing hepatocellular carci‑ noma and cholangiocarcinoma, presents a substantial global mortality burden; it ranks sixth in incidence among all cancer types and is the third leading cause of cancer‑related death (4) . The global age‑standardized incidence of primary liver cancer was 8.657 per 100,000 in 2017 (5) . China, where the prevalence of hepatitis B virus is high, accounts for ~50% of the global liver cancer burden (6) . Hepatectomy remains the cornerstone of treatment strategies for liver cancer, comple‑ mented by systemic therapies, such as chemotherapy and immunotherapy (7) .  \nSynchronous tumors, defined as independent primary tumors that arise simultaneously, have become increasingly recognized with advancements in diagnostic and therapeutic methods. Multiple primary malignancies are not uncommon in clinical practice; however, cases involving synchronous primary gastric and liver cancer are rarely reported (8,9) . The present study aimed to present the diagnosis and treatment progress of a patient with synchronous primary gastric and liver cancer, providing i","cbCaiqroSfqoLGU7","https://ap.wps.com/l/cbCaiqroSfqoLGU7","pdf",4639338,"English","# Abstract\n# Introduction\n# Case report\n## Case presentation","[{\"question\":\"Why are synchronous primary gastric and liver cancers considered rare?\",\"answer\":\"Multiple primary malignancies can occur clinically, but reports of synchronous primary gastric and liver cancer are exceedingly rare.\"},{\"question\":\"What treatments were performed for the patient in the case report?\",\"answer\":\"The patient underwent endoscopic submucosal dissection for gastric lesions and laparoscopic resection of a small liver tumor.\"},{\"question\":\"What did the pathology show and what was the follow-up outcome?\",\"answer\":\"Pathology revealed moderately differentiated intramucosal adenocarcinoma in the stomach and well-differentiated hepatocellular carcinoma in the liver. After 3 years, the patient remained healthy with no evidence of recurrence.\"}]","Synchronous occurrence of primary gastric and liver cancer - A case report | PDF",1790191819,18]