[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327285-105":59,"doc-detail-327285-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","synchronous-multiple-primary-neoplasms-of-the-esophagus-rectosigmoid-and-central-nervous-system-case-report-management-and-outcomes","Synchronous multiple primary neoplasms of the esophagus, rectosigmoid and central nervous system - Case report - Management and outcomes","","Multiple primary neoplasms (MPN) are uncommon tumors that arise independently within the same individual and may present as simultaneous, synchronous, or metachronous disease. A 77-year-old man presented with melena and constipation for two months and was found to have synchronous rectosigmoid and esophageal adenocarcinomas along with a calcified intracranial lesion consistent with meningioma. He underwent rectosigmoid surgery only based on preference and received chemotherapy. After two chemotherapy cycles, he developed acute intestinal obstruction and died.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synchronous-multiple-primary-neoplasms-of-the-esophagus-rectosigmoid-and-central-nervous-system-case-report-management-and-outcomes/327285/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synchronous-multiple-primary-neoplasms-of-the-esophagus-rectosigmoid-and-central-nervous-system-case-report-management-and-outcomes/327285.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are multiple primary neoplasms (MPN) and how are they classified as synchronous or metachronous?","Question",{"text":112,"@type":113},"MPN are two or more histologically distinct tumors arising independently in the same individual. Synchronous disease is diagnosed within 6 months, while metachronous disease is diagnosed more than 6 months later.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What diagnoses were identified in the reported 77-year-old patient?",{"text":117,"@type":113},"The patient was diagnosed with rectosigmoid and esophageal adenocarcinomas, along with a calcified intracranial lesion consistent with meningioma.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the patient managed and what was the outcome?",{"text":121,"@type":113},"He underwent surgery for the rectosigmoid lesion only, according to patient preference, and received chemotherapy. He later developed acute intestinal obstruction after two chemotherapy cycles and died.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327285,1790415833,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","International Journal of Surgery Case Reports 117 (2024) 109566  \nContents lists available at ScienceDirect  \nInternational Journal of Surgery Case Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/ijscr)[ www.elsevier.com/locate/ijscr](homepage: www.elsevier.com/locate/ijscr)  \n| Case report\u003Cbr>Synchronous multiple primary neoplasms of the esophagus, rectosigmoid and central nervous system\u003Cbr>*\u003Cbr>Suvendu Sekhar Jena , Samiran Nundy\u003Cbr>Institute of Surgical Gastroenterology, GI and HPB Oncosurgery and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi 110060, India |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>MPN\u003Cbr>Multiple primary neoplasm Colorectal malignancy Esophageal malignancy |  | Introduction: Multiple primary neoplasms (MPN) are rare and can affect any system especially the upper aerodigestive system. They can be simultaneous, synchronous or metachronous. Their management depends on the individual organ system affected and simultaneous resection is possible as shown by T. Suzuki.\u003Cbr>Presentation of case: We encountered a 77-year-old male who had had malena and constipation for 2 months and on investigation was found to have a rectosigmoid and an esophageal adenocarcinoma as well as a calcified lesion in the brain. He underwent surgery for the rectosigmoid growth only (according to the patient's preference) and received chemotherapy. Unfortunately, he developed acute intestinal obstruction after 2 cycles of chemotherapy and died.\u003Cbr>Discussion: MPNS are defined as presence of two or more histologically distinct tumours in the same individual. It can be synchronous or metachronous. Various factors like genetic and environmental play crucial role in its development. Management of these depends up on the status of the patient, stage of disease.\u003Cbr>Conclusion: MPNS are rare but their rising trend suggests it should be kept in mind while working up a patient with any malignancy. |\n\n1. Introduction  \nMultiple primary neoplasms (MPN) are defined as multiple tumours originating independently in a single individual and can be, as per International Association of Cancer Registries and International Agency for Research on Cancer definition, simultaneous (diagnosed at the sametime), synchronous (diagnosed within 6 months), or metachronous (diagnosed more than 6 months later) [1]. They have an incidence of 1–3 % but there has been a rise in recent years perhaps due to an increasing survival of patients with malignancy and the availability of better diagnosing or imaging techniques [2]. Though rare, a low threshold of suspicion and early diagnosis can provide a better management strategy in terminally ill patients. Here, we describe a 77-yearold male who had synchronous recto-sigmoid colonic and esophageal malignancies as well as a meningioma. Work has been reported in line with the SCARE criteria [3].  \n2. Presentation of case  \nA 77-year-old male, retired school teacher from Northern India, who  \nhad type II diabetes mellitus and hypertension for 10 years as well as coronary artery disease presented to us with a history of malena and constipation for 2 months. This was associated with anorexia and loss of weight of around 13 kg. There was no vomiting, dysphagia, loss of consciousness, seizure, or hematochezia. There was no past surgical history or any history of malignant disease in the family. The systemic and rectal examinations were normal.  \nOn investigation, he had low hemoglobin of 6.1 g/dl which had been managed with blood transfusion and iron supplements. Abdominal ultrasonography showed cystic lesions in both kidneys with prostatomegaly. Colonoscopy revealed an ulceroproliferative growth in the sigmoid colon extending from 10 cm from the anal verge to 18 cm and biopsy showed it to be a moderate to poorly differentiated adenocarcinoma (Fig. 1A & B). Upper gastrointestinal endoscopy showed Barrett's esophagus and biopsy showed high-grade dysplasia (Fig. 2A ","cbCaieeYYwNUTc4L","https://ap.wps.com/l/cbCaieeYYwNUTc4L","pdf",3322434,"English","# Introduction\n## Definition and timing of MPN\n# Presentation of case\n## Symptoms and initial assessment\n## Endoscopy, biopsy, and imaging workup\n## Management decision and procedures\n## Postoperative course and outcome\n# Discussion\n## Pathology, risk factors, and management principles\n# Conclusion","[{\"question\":\"What are multiple primary neoplasms (MPN) and how are they classified as synchronous or metachronous?\",\"answer\":\"MPN are two or more histologically distinct tumors arising independently in the same individual. Synchronous disease is diagnosed within 6 months, while metachronous disease is diagnosed more than 6 months later.\"},{\"question\":\"What diagnoses were identified in the reported 77-year-old patient?\",\"answer\":\"The patient was diagnosed with rectosigmoid and esophageal adenocarcinomas, along with a calcified intracranial lesion consistent with meningioma.\"},{\"question\":\"How was the patient managed and what was the outcome?\",\"answer\":\"He underwent surgery for the rectosigmoid lesion only, according to patient preference, and received chemotherapy. He later developed acute intestinal obstruction after two chemotherapy cycles and died.\"}]","Synchronous multiple primary neoplasms of the esophagus, rectosigmoid and central nervous system - Case report - Management and outcomes | PDF",1789976906]