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A case is presented of simultaneous MPMN involving three endocrine organs, with literature review to support accurate diagnosis and multidisciplinary management.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/synchronous-multiple-primary-malignant-neoplasms-in-breast-kidney-and-bilateral-thyroid-a-case-report/376595/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/synchronous-multiple-primary-malignant-neoplasms-in-breast-kidney-and-bilateral-thyroid-a-case-report/376595.png","ImageObject",300,407,{"name":42,"@type":43},"Logic","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What are synchronous multiple primary malignant neoplasms (SMPMNs)?","Question",{"text":63,"@type":64},"SMPMNs refer to two or more pathologically diagnosed primary malignant tumors occurring within six months of the primary tumor diagnosis in the same person.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is the reported case clinically notable?",{"text":68,"@type":64},"Reports of breast and thyroid dual cancers are common, but an additional diagnosis of a kidney primary cancer in the same individual is rare.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the conclusion emphasize for patient management?",{"text":72,"@type":64},"Accurate diagnosis and multidisciplinary management are increasingly important when dealing with this challenging situation involving multiple endocrine organs.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},376595,1790542437,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 March 6; 11(7): 1513-1520  \nDOI: 10.12998/wjcc.v11.i7.1513 ISSN 2307-8960 (online)  \nCASE REPORT  \nSynchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid: A case report  \nMiao-Miao Jia, Bin Yang, Chao Ding, Ya-Rong Yao, Jun Guo, Hai-Bo Yang  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Dimofte GM, Romania; Mehdipour P, Iran  \nReceived: October 24, 2022  \nPeer-review started: October 24, 2022  \nFirst decision: January 20, 2023  \nRevised: February 2, 2023  \nAccepted: February 15, 2023  \nArticle in press: February 15, 2023  \nPublished online: March 6, 2023  \nMiao-Miao Jia, Bin Yang, Chao Ding, Ya-Rong Yao, Jun Guo, Hai-Bo Yang, Department of General Surgery, Shanxi Bethune Hospital/General Surgery Department, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi Province, China  \nCorresponding author: Hai-Bo Yang, Doctor, Surgeon, Department of General Surgery, Shanxi Bethune Hospital/General Surgery Department, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, [China.](China. yanghb2006460@126.com)[ yanghb2006460@126.com](China. yanghb2006460@126.com)  \nAbstract  \nBACKGROUND  \nMultiple primary malignant neoplasms (MPMNs) are rare, while synchronous MPMNs (SMPMNs) are even less common. Owing to the progression of medical technology and the extension of life expectancy, its incidence is gradually increasing.  \nCASE SUMMARY  \nAlthough reports of breast and thyroid dual cancers are common, cases of an additional diagnosis of kidney primary cancer within the same individual are rare.  \nCONCLUSION  \nWe present a case of simultaneous MPMN of three endocrine organs, reviewing the relevant literature to enhance our understanding of SMPMNs while emphasizing the increasingly important need for accurate diagnosis and multidisciplinary management whenever this challenging situation arises.  \nKey Words: Synchronous; Multiple primary malignant neoplasms; Breast cancer; Kidney cancer; Bilateral thyroid cancer; Tumor neoplasm; Case report  \n©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 1513 March 6, 2023  Volume 11  Issue 7   \nJia MM et al. Multiple primary malignant neoplasms  \nCore Tip: Multiple primary malignant neoplasms (MPMNs) are rare, while synchronous MPMNs are even less common. Owing to the progression of medical technology and the extension of life expectancy, its incidence is gradually increasing. Although reports of breast and thyroid dual cancers are common, cases of an additional diagnosis of kidney primary cancer within the same individual are rare.  \nCitation: Jia MM, Yang B, Ding C, Yao YR, Guo J, Yang HB. Synchronous multiple primary malignant neoplasms  \nin breast, kidney, and bilateral thyroid: A case report. World J Clin Cases 2023; 11(7): 1513-1520  \nURL: [https://www.wjgnet.com/2307-8960/full/v11/i7/1513.htm](https://www.wjgnet.com/2307-8960/full/v11/i7/1513.htm)  \nDOI: [https://dx.doi.org/10.12998/wjcc.v11.i7.1513](https://dx.doi.org/10.12998/wjcc.v11.i7.1513)  \nINTRODUCTION  \nMultiple primary malignant neoplasms (MPMNs) are generally defined as the occurrence of two or more pathologically diagnosed primary malignant tumors in ≥ 1 organ or tissue in the same person[1] . Although inconsistent among various studies, an a","cbCaimekoWweg3Or","https://ap.wps.com/l/cbCaimekoWweg3Or","pdf",6983778,"English","# Abstract\n## Background\n## Case summary\n## Conclusion\n# Introduction\n# Case presentation\n## Chief complaints\n## History of present illness\n## History of past illness\n## Personal and family history\n## Physical examination\n# Core tip","[{\"question\":\"What are synchronous multiple primary malignant neoplasms (SMPMNs)?\",\"answer\":\"SMPMNs refer to two or more pathologically diagnosed primary malignant tumors occurring within six months of the primary tumor diagnosis in the same person.\"},{\"question\":\"Why is the reported case clinically notable?\",\"answer\":\"Reports of breast and thyroid dual cancers are common, but an additional diagnosis of a kidney primary cancer in the same individual is rare.\"},{\"question\":\"What does the conclusion emphasize for patient management?\",\"answer\":\"Accurate diagnosis and multidisciplinary management are increasingly important when dealing with this challenging situation involving multiple endocrine organs.\"}]","Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid - A case report | PDF",1790220125,23]