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Histopathology revealed synchronous small cell carcinoma in two resected lymph nodes, with the small cell primary not identifiable even by whole-body imaging, prompting chemotherapy for hilar node metastasis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/synchronous-multiple-lung-cancers-with-hilar-lymph-node-metastasis-of-small-cell-carcinoma-a-case-report/386286/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/synchronous-multiple-lung-cancers-with-hilar-lymph-node-metastasis-of-small-cell-carcinoma-a-case-report/386286.png","ImageObject",300,407,{"name":42,"@type":43},"Terk","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does “synchronous multiple lung cancers” mean in this case?","Question",{"text":63,"@type":64},"It refers to the simultaneous presence of two or more primary lung tumors at the same time, which creates diagnostic and treatment challenges.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What were the key diagnostic findings for the patient’s lung and lymph nodes?",{"text":68,"@type":64},"Transbronchial lung biopsy showed squamous cell carcinoma. Surgery with nodal dissection found that two lymph nodes (#12u and #11s) harbored small cell carcinoma, while the small cell primary lesion could not be identified on whole-body imaging.",{"name":70,"@type":61,"acceptedAnswer":71},"How was treatment determined given the unknown origin of the small cell carcinoma?",{"text":72,"@type":64},"Chemotherapy was initiated for hilar lymph node metastasis of small cell carcinoma of unknown origin after histopathology confirmed small cell carcinoma in the resected nodes and no distant metastases were observed.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},386286,1790318414,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":118},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 September 6; 11(25): 5919-5925  \nDOI: 10.12998/wjcc.v11.i25.5919 ISSN 2307-8960 (online)  \nCASE REPORT  \nSynchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma: A case report  \nRyusei Yoshino, Nana Yoshida, Shunsuke Yasuda, Akane Ito, Masaki Nakatsubo, Sayaka Yuzawa, Masahiro Kitada  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): E  \nP-Reviewer: Eccher A, Italy; Lin Q, China; Long X, China  \nReceived: March 25, 2023  \nPeer-review started: March 25, 2023  \nFirst decision: June 21, 2023  \nRevised: July 5, 2023  \nAccepted: August 7, 2023  \nArticle in press: August 7, 2023  \nPublished online: September 6, 2023  \nRyusei Yoshino, Nana Yoshida, Shunsuke Yasuda, Akane Ito, Masaki Nakatsubo, Masahiro Kitada,  \nThoracic Surgery and Breast Surgery, Asahikawa Medical University, Asahikawa 078-8510, Japan  \nSayaka Yuzawa, Diagnostic Pathology, Asahikawa Medical University Hospital, Hokkaido 078- 8510, Japan  \nCorresponding author: Ryusei Yoshino, MD, Doctor, Thoracic Surgery and Breast Surgery, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa-shi, Hokkaido, Asahikawa 078-8510, [Japan.](Japan. ryusei.0628.ppp@gmail.com)[ ryusei.0628.ppp@gmail.com](Japan. ryusei.0628.ppp@gmail.com)  \nAbstract  \nBACKGROUND  \nSynchronous multiple lung cancers are rare and refer to the simultaneous presence of two or more primary lung tumors, which present significant challenges in terms of diagnosis and treatment.  \nCASE SUMMARY  \nWe report a case of multiple synchronous lung cancers with hilar lymph node metastasis of small cell carcinoma of unknown origin in a 73-year-old man. Transbronchial lung biopsy revealed squamous cell carcinoma. Although enlargement of lymph node 12u was detected, no distant metastases were observed. The patient was preoperatively diagnosed with T1cN0M0 and underwent thoracoscopic right upper lobectomy with nodal dissection (ND2a) . Based on histopathological findings, the primary lesion was squamous cell carcinoma. A microinvasive adenocarcinoma was also observed on the cranial side of the primary lesion. Tumors were detected in two resected lymph nodes (\\#12u and \\#11s) . Both tumors were pathologically diagnosed as small cell carcinomas. The primary lesion of the small cell carcinoma could not be identified even by whole-body imaging; however, chemotherapy was initiated for hilar lymph node metastasis of the small cell carcinoma of unknown origin.  \nCONCLUSION  \nMultiple synchronous lung cancers can be accompanied by hilar lymph node metastasis of small cell carcinomas of unknown origin.  \nKey Words: Small cell carcinoma; Synchronous multiple lung cancers; Squamous cell  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 5919 September 6, 2023  Volume 11  Issue 25   \nYoshino R et al. Synchronous multiple LCs with hilar LNM  \ncarcinoma; Adenocarcinoma; Chemotherapy; Case report  \n©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Synchronous multiple lung cancer is relatively rare. We report a case of synchronous multiple lung cancers with lymph node metastasis in the hilar region of a small cell carcinoma of unknown origin. Immunohistochemistry was helpful in aiding the diagnosis. As such cases have a poor prognosis, an accurate diagnosis is necessary to determine treatment options.  \nCitation: Yoshino R, Yoshida N, Yasuda S, Ito A, Nakatsubo M, Yuzawa S, Kitada M. Synchronous multiple lung cancers with hilar  \nlymph node metastasis of small cell carcin","cbCaiiQ8okDVIWVB","https://ap.wps.com/l/cbCaiiQ8okDVIWVB","pdf",10158180,"English","# Case report\n## Abstract (Background, Case Summary, Conclusion)\n## Introduction\n## Chief complaints\n## History of present illness\n## History of past illness","[{\"question\":\"What does “synchronous multiple lung cancers” mean in this case?\",\"answer\":\"It refers to the simultaneous presence of two or more primary lung tumors at the same time, which creates diagnostic and treatment challenges.\"},{\"question\":\"What were the key diagnostic findings for the patient’s lung and lymph nodes?\",\"answer\":\"Transbronchial lung biopsy showed squamous cell carcinoma. Surgery with nodal dissection found that two lymph nodes (#12u and #11s) harbored small cell carcinoma, while the small cell primary lesion could not be identified on whole-body imaging.\"},{\"question\":\"How was treatment determined given the unknown origin of the small cell carcinoma?\",\"answer\":\"Chemotherapy was initiated for hilar lymph node metastasis of small cell carcinoma of unknown origin after histopathology confirmed small cell carcinoma in the resected nodes and no distant metastases were observed.\"}]","Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma - A case report | PDF",1790273099]