[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328840-105":59,"doc-detail-328840-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","synchronous-laryngeal-cancer-case-report","Synchronous laryngeal cancer - Case report","","Multiple primary malignant tumors with different histological origins may occur within the same person, while synchronous cancers are diagnosed in the same patient at the same time or within six months after the first tumor is identified. This case report describes a patient with synchronous laryngeal cancer with two localizations managed by surgical excision of the tumors. Histopathological and immunohistochemistry findings confirmed synchronous laryngeal cancer. Laryngeal cancer is typically treated with surgical resection followed by oncological therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synchronous-laryngeal-cancer-case-report/328840/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synchronous-laryngeal-cancer-case-report/328840.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How are synchronous laryngeal cancers defined in the paper?","Question",{"text":112,"@type":113},"Synchronous cancers are two or more primary cancers diagnosed in the same patient at the same time or within six months after identifying the first tumor.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What symptoms led to hospital admission for the patient?",{"text":117,"@type":113},"The patient presented with persistent dysphonia (hoarseness) and progressive dysphagia over the previous three months.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the diagnosis confirmed?",{"text":121,"@type":113},"Biopsies taken from the two laryngeal tumors indicated squamous cell carcinoma, and histopathological and immunohistochemistry examinations confirmed synchronous laryngeal cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328840,1790116893,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Rom J Morphol Embryol 2024, 65(2):309–315 ISSN (print) 1220–0522, ISSN (online) 2066–8279 doi: 10.47162/RJME.65.2.18  \nCASE REPORT  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nSynchronous laryngeal cancer  \nMIRCEA SORIN CIOLOFAN1), FLORIN ANGHELINA1), ALEXANDRU NICOLAE VLĂESCU2), MIHAELA ROXANA MITROI1), ALINA NICOLETA CĂPITĂNESCU1), ELENA IONIŢĂ1),  \nIULICĂ IONIŢĂ1), NINA IONOVICI3), DANIELA VRÎNCEANU4,5), CARMEN AURELIA MOGOANTĂ1)  \n1) Department of Otorhinolaryngology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania  \n2) Department of Otorhinolaryngology, Dr. Vlăescu Central Polyclinic, Craiova, Romania  \n3) Department of Occupational Medicine, University of Medicine and Pharmacy of Craiova, Romania  \n4) Department of ENT, Bucharest Emergency University Hospital, Bucharest, Romania  \n5)Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  \nAbstract  \nMultiple primary cancers are usually defined as primary malignant tumors of different histological origins in one person. Synchronous cancers are defined as two or more primary cancers diagnosed in the same patient at the same time or within six months after identifying the first tumor, and those cancers that develop at more than a six-month interval are termed as metachronous multiple primary cancers. Our study comprised of a patient with synchronous laryngeal cancer with double localizations. The case was solved through surgical excision of the tumors. Histopathological and immunohistochemistry examinations revealed synchronous laryngeal cancer. Laryngeal cancer should usually be managed through surgical resection, followed by oncological treatment.  \nKeywords: larynx, synchronous cancer, total laryngectomy, histopathology, immunohistochemistry.  \n􀀕 Introduction  \nLaryngeal cancer comprises up to one third of all head and neck cancers, being the second most common cancer within the head and neck, making it an important cause of morbidity and mortality. It may involve various laryngeal localizations, influencing the presentation signs and symptoms, dissemination, and treatment options [1, 2] . Given the involved site and associated symptoms, as well as patient background, history of smoking and alcohol use, level of education and socio-economic status, patients will approach their physician in the early or late stages ofthe disease. Given the stage of the disease, certain functions of the larynx may be altered, such as respiration (breathing), deglutition (swallowing), phonation, and at times taste and smell [3] .  \nMost laryngeal cancers are squamous cell carcinoma (SCC), comprising of up to 95%[4, 5] . Most are welldifferentiated SCC, while others represent squamous cell variants (verrucous, sarcomatous, neuroendocrine carcinomas)  \n[1] .  \nSynchronous cancers consist of two or more malignant tumors diagnosed within the same patient at the same time. They are rarely encountered, even less within the same organ [5] .  \nAim  \nThe paper is aimed at presenting the case of two synchronous malignant tumors situated within the larynx and a review of the literature.  \n􀀕 Case presentation  \nWe present the case of a 59-year-old male patient, admitted to the Ear, Nose and Throat (ENT) Clinic of the Emergency County Clinical Hospital of Craiova, Romania, for persistent dysphonia (hoarseness) and progressive dysphagia over the past three months.  \nThe patient had a medical history of type 2 diabetes, with right lower limb amputation, hyperuricemia, chronic ischemic cardiomyopathy, hypertension accompanied by high cardiovascular risk. The patient was a heavy smoker:  \n44 years with more than 20 cigarettes/day and had a history of alcohol use, especially beer and wine.  \nPhysical examination revealed small cervical lymphadenopathy upon inspection and palpation, both on the right and left sides of the neck.  \nOn clinical examination, indirect laryngoscopy revealed two tumoral masses, one l","cbCaivy7jhlJcnAT","https://ap.wps.com/l/cbCaivy7jhlJcnAT","pdf",3803739,"English","# Introduction\n# Aim\n# Case presentation\n## Patient presentation and assessment\n## Diagnostic workup\n## Multidisciplinary treatment decision\n## Surgical management","[{\"question\":\"How are synchronous laryngeal cancers defined in the paper?\",\"answer\":\"Synchronous cancers are two or more primary cancers diagnosed in the same patient at the same time or within six months after identifying the first tumor.\"},{\"question\":\"What symptoms led to hospital admission for the patient?\",\"answer\":\"The patient presented with persistent dysphonia (hoarseness) and progressive dysphagia over the previous three months.\"},{\"question\":\"How was the diagnosis confirmed?\",\"answer\":\"Biopsies taken from the two laryngeal tumors indicated squamous cell carcinoma, and histopathological and immunohistochemistry examinations confirmed synchronous laryngeal cancer.\"}]","Synchronous laryngeal cancer - Case report | PDF",1789981285,18]