[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-359544-105":59,"doc-detail-359544-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","synchronous-gastric-metastasis-from-sigmoid-colon-cancer-a-case-report","Synchronous Gastric Metastasis From Sigmoid Colon Cancer - A Case Report","","Colorectal cancer is a leading global malignancy, yet gastrointestinal tract metastases are exceptionally uncommon. This case report describes a 78-year-old man diagnosed with synchronous gastric and sigmoid colon cancers. He underwent simultaneous radical subtotal gastrectomy and anterior resection. Pathology showed moderately differentiated adenocarcinoma in both sites, with IHC positive for CK20 and CDX2 and negative for CK7, confirming colorectal origin of the gastric lesion. Clinicians should consider metastatic gastric involvement in other solid tumors, whether synchronous or metachronous.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synchronous-gastric-metastasis-from-sigmoid-colon-cancer-a-case-report/359544/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synchronous-gastric-metastasis-from-sigmoid-colon-cancer-a-case-report/359544.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What makes the gastric lesion in this case confirm a metastasis from sigmoid colon cancer?","Question",{"text":113,"@type":114},"Immunohistochemistry of the resected gastric specimen was CK20-positive and CDX2-positive but CK7-negative, matching colorectal cancer features. This confirmed the gastric lesion originated from the sigmoid colon cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were the synchronous gastric and colorectal cancers treated?",{"text":118,"@type":114},"The patient received simultaneous radical subtotal gastrectomy and anterior resection. After surgery, he was discharged without complications and received adjuvant chemotherapy with the XELOX regimen.",{"name":120,"@type":111,"acceptedAnswer":121},"What follow-up outcome was reported after treatment?",{"text":122,"@type":114},"Regular imaging and endoscopy were continued, and adjuvant cytotoxic therapy was not given further for 5 years. The document then continues describing subsequent follow-up.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},359544,1790628565,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Clinical Case Reports  \nCASE REPORT  OPEN ACCESS   \nSynchronous Gastric Metastasis From Sigmoid Colon Cancer: A Case Report  \nSeung Jong Oh1  | Seul-Gi Oh2  | Sun Keun Choi1   \n1Department of Surgery, Inha University Hospital, Inha University College of Medicine, Incheon, South Korea | 2Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea  \nCorrespondence: Sun Keun Choi ([karam66@inha.ac.kr](karam66@inha.ac.kr))  \nReceived: 20 July 2025 | Revised: 18 March 2026 | Accepted: 30 March 2026  \nKeywords: case report | neoplasm metastasis | sigmoid neoplasm | stomach neoplasm | synchronous  \nABSTRACT  \nColorectal cancer is the third most common cancer worldwide, and as such is a significant global health concern. Distant metastases of colorectal cancer to the lung, liver, and bone are well documented, while gastrointestinal tract (GIT) metastases are very rare. Herein, we report a case of gastric metastasis from sigmoid colon cancer. A 78-year-old male was diagnosed with both gastric and colorectal cancer, which occurred synchronously. The presence of two primary cancers was diagnosed, and radical subtotal gastrectomy and anterior resection were performed simultaneously. The postoperative pathology report showed a moderately differentiated adenocarcinoma in the sigmoid colon and stomach. Immunohistochemical (IHC) analysis revealed that the resected gastric specimens showed tumor cells that were positive for both cytokeratin 20 (CK20) and caudal-type homeobox gene 2 (CDX2) and negative for CK7. This confirmed that the gastric lesion was a metastasis from colorectal cancer. Clinicians should be aware of the potential presence of metastatic gastric cancer, whether synchronous or metachronous, in other solid organ malignancies.  \n1 | Introduction  \nColorectal cancer is the third most common cancer worldwide and the second leading cause of cancer-related mortality in the world [1]. Approximately 20% of patients with colorectal cancer already have metastases at the time of initial diagnosis, with the liver (50%) and lung (10%–15%) being the most commonly involved sites of metastasis from colorectal cancer. Primary cancers from other organs rarely metastasize to the stomach. The rarity of stomach metastasis from colorectal cancer is further supported by a large-scale autopsy study, which reported a range of 0.7%–5.4% for gastric metastases across various cancers, indicating that colorectal cancer contributes only minimally within this range [2]. Here, we report a notable case of synchronous metastasis to the stomach in a sigmoid colon cancer patient.  \n2 | Case Presentation  \nChief complaints and history of present illness: A 78-year-old male underwent upper and lower endoscopy as part of a routine health examination.  \nHistory of past illness: The patient had Alzheimer's disease.  \nLaboratory examinations: The carcinoembryonic antigen (CEA) level was 0.87 ng/mL.  \nImaging examinations: The esophagogastroduodenoscopy (EGD) revealed a 3 × 2 cm ulcerofungating mass in the lesser curvature side of the mid antrum of the stomach (Figure 1A,B), and a colonoscopy showed a 4 × 2 cm ulcerofungating mass  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.  \nClinical Case Reports, 2026; 14:e72513 1 of 6  \n[https://doi.org/10.1002/ccr3.72513](https://doi.org/10.1002/ccr3.72513)  \nKey Clinical Message  \nA rare case of synchronous gastric metastasis from sigmoid colon cancer is presented. Immunohistochemistry (CK20+, CDX2+, CK7-) confirmed the gastric lesion originated from colorectal cancer, highlighting the need to consider metastatic gastric involvement in patients with other primary malignancies of solid organs.  \nin the distal sigmoid colon, located 12 cm from the anal ","cbCaihxbbBus9r8n","https://ap.wps.com/l/cbCaihxbbBus9r8n","pdf",1360959,"English","# Abstract\n# Introduction\n# Case Presentation\n## Chief complaints and history of present illness\n## History of past illness\n## Laboratory examinations\n## Imaging examinations\n# Final Diagnosis\n# Treatment\n# Outcome and Follow-Up","[{\"question\":\"What makes the gastric lesion in this case confirm a metastasis from sigmoid colon cancer?\",\"answer\":\"Immunohistochemistry of the resected gastric specimen was CK20-positive and CDX2-positive but CK7-negative, matching colorectal cancer features. This confirmed the gastric lesion originated from the sigmoid colon cancer.\"},{\"question\":\"How were the synchronous gastric and colorectal cancers treated?\",\"answer\":\"The patient received simultaneous radical subtotal gastrectomy and anterior resection. After surgery, he was discharged without complications and received adjuvant chemotherapy with the XELOX regimen.\"},{\"question\":\"What follow-up outcome was reported after treatment?\",\"answer\":\"Regular imaging and endoscopy were continued, and adjuvant cytotoxic therapy was not given further for 5 years. The document then continues describing subsequent follow-up.\"}]","Synchronous Gastric Metastasis From Sigmoid Colon Cancer - A Case Report | PDF",1790137145,15]