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Highlights that genetic polyposis syndromes and hereditary conditions, as well as chronic inflammatory diseases such as inflammatory bowel disease and Crohn’s disease, increase risk. Summarizes reported dual cancers in sporadic cases while noting excluded patients due to incomplete data and genetic or gastric stump cancer factors. Discusses the roles of key gene mutations and epithelial field defects from chronic inflammation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synchronous-gastric-and-colon-cancers-important-to-consider-hereditary-syndromes-and-chronic-inflammatory-disease-associations/330376/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synchronous-gastric-and-colon-cancers-important-to-consider-hereditary-syndromes-and-chronic-inflammatory-disease-associations/330376.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes synchronous or metachronous gastric and colon cancers a diagnostic and treatment challenge?","Question",{"text":112,"@type":113},"Primary malignancies in different gastrointestinal sites occurring simultaneously or sequentially create a unique diagnostic and therapeutic challenge, requiring coordinated multidisciplinary management and surveillance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which hereditary syndromes and inflammatory diseases are associated with higher risk of multiple-site gastrointestinal cancers?",{"text":117,"@type":113},"Genetic polyposis and hereditary conditions such as familial adenomatous polyposis, Lynch syndromes, hereditary diffuse gastric cancer, Peutz-Jeghers syndrome, and Crohn’s disease are discussed, alongside chronic inflammatory bowel disease risks.",{"name":119,"@type":110,"acceptedAnswer":120},"How do genetic and chronic inflammatory processes differ in cancer progression pathways?",{"text":121,"@type":113},"Cancers linked to genetic mutations are described as progressing via an adenoma–carcinoma sequence, while cancers related to inflammatory bowel disease progress through a dysplasia–carcinoma sequence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330376,1790015205,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 March 15; 16(3): 571-576  \nDOI: 10.4251/wjgo.v16.i3.571 ISSN 1948-5204 (online)  \nEDITORIAL  \nSynchronous gastric and colon cancers: Important to consider hereditary syndromes and chronic inflammatory disease associations  \nSantosh Shenoy  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C, C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Dai DL, China; Ding J, China  \nReceived: October 31, 2023  \nPeer-review started: October 31, 2023  \nFirst decision: December 18, 2023  \nRevised: December 23, 2023  \nAccepted: January 30, 2024  \nArticle in press: January 30, 2024  \nPublished online: March 15, 2024  \nSantosh Shenoy, Department of General Surgery, Kansas City VA Medical Center, University of Missouri-Kansas City, Kansas, MO 64128, United States  \nCorresponding author: Santosh Shenoy, FACS, MD, Professor, Surgeon, Department of General Surgery, Kansas City VA Medical Center, University of Missouri-Kansas City, 4801 ELinwood, Kansas, MO 64128, [United States.](United States. shenoy2009@hotmail.com)[ shenoy2009@hotmail.com](United States. shenoy2009@hotmail.com)  \nAbstract  \nIn this editorial we comment on the manuscript, describing management and surveillance strategies in synchronous and metachronous, gastric and colon cancers. Synchronous or metachronous primary malignancies at different sites of the gastrointestinal tract pose a unique diagnostic and therapeutic challenge. Multidisciplinary services and strategies are required for the management of multiple site primary malignancies, to provide the best oncological outcomes. Although this study highlights the dual cancers in 76 sporadic cases, the authors excluded 55 patients due to combination of factors which includes; incomplete clinical data, genetic syndrome, gastric stump cancers. In addition, the authors did not elaborate if any patients presented with signet ring cell morphology, Ecadherin mutations or presence of inflammatory bowel disease. Genetic and mutational errors and epithelial field defects from chronic inflammatory diseases of the gastrointestinal tract are important when considering synchronous gastric and colonic cancers. We will briefly discuss these in this editorial.  \nKey Words: Synchronous gastric; Colon cancers; Gene mutation; Chronic inflammation  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 571 March 15, 2024  Volume 16  Issue 3   \nShenoy S. Synchronous gastric and colon cancers  \nCore Tip: Certain genetic polyposis syndromes and inflammatory familial diseases are associated with increased risks for multiple site gastrointestinal cancer, specifically gastroduodenal and colon cancers. These include familial adenomatous polyposis, Lynch syndromes, Hereditary diffuse gastric cancer, Peutz-Jeghers syndrome, Crohn’s disease. Mutations in APC gene, MMR genes, CDH1 gene and STK11 gene respectively. Generally, cancers associated with genetic mutations progress through adenoma carcinoma sequence while inflammatory bowel disease progress to malignancy through dysplasiacarcinoma sequence.  \nCitation: Shenoy S. Synchronous gastric and colon cancers: Important to consider hereditary syndromes and chronic inflammatory disease associations. World J Gastrointest Oncol 2024; 16(3): 571-576  \nURL: [https://www.wjgnet.com/1948-5204/full/v16/i3/571.htm](https://www.wjgnet.com/1948-5204/full/v16/i3/571.htm)  \nDOI: [https://dx.doi.org/10.4251/wjgo.v16.i3.571](https://dx.doi.org/10.4251/wjgo.v16.i3.571)  \nSynchronous or metachronous primary cancers a","cbCaipxsWRYahEMa","https://ap.wps.com/l/cbCaipxsWRYahEMa","pdf",405451,"English","# Editorial\n## Core Tip\n## Abstract\n## Key Words\n## Main Discussion","[{\"question\":\"What makes synchronous or metachronous gastric and colon cancers a diagnostic and treatment challenge?\",\"answer\":\"Primary malignancies in different gastrointestinal sites occurring simultaneously or sequentially create a unique diagnostic and therapeutic challenge, requiring coordinated multidisciplinary management and surveillance.\"},{\"question\":\"Which hereditary syndromes and inflammatory diseases are associated with higher risk of multiple-site gastrointestinal cancers?\",\"answer\":\"Genetic polyposis and hereditary conditions such as familial adenomatous polyposis, Lynch syndromes, hereditary diffuse gastric cancer, Peutz-Jeghers syndrome, and Crohn’s disease are discussed, alongside chronic inflammatory bowel disease risks.\"},{\"question\":\"How do genetic and chronic inflammatory processes differ in cancer progression pathways?\",\"answer\":\"Cancers linked to genetic mutations are described as progressing via an adenoma–carcinoma sequence, while cancers related to inflammatory bowel disease progress through a dysplasia–carcinoma sequence.\"}]","Synchronous gastric and colon cancers - Important to consider hereditary syndromes and chronic inflammatory disease associations | PDF",1789988547,18]