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Standardized Incidence Ratios compare observed subsequent cancers with expected regional malignancy rates. Results show increased synchronous risk in both sexes and sex-specific patterns for major cancer sites, with females demonstrating higher metachronous excess risk soon after diagnosis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/synchronous-and-metachronous-multiple-primary-cancers-in-melanoma-survivors-a-gender-perspective/378001/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/synchronous-and-metachronous-multiple-primary-cancers-in-melanoma-survivors-a-gender-perspective/378001.png","ImageObject",300,407,{"name":42,"@type":43},"Kyle","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What distinguishes synchronous and metachronous multiple primary cancers in melanoma survivors?","Question",{"text":63,"@type":64},"Synchronous cancers occur concurrently with the melanoma-related diagnosis timeframe, while metachronous cancers arise later. The study quantifies both types by comparing observed subsequent cancers with expected rates.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the risk of subsequent cancers measured?",{"text":68,"@type":64},"The study calculates Standardized Incidence Ratios (SIRs) as the ratio between observed subsequent cancers among melanoma survivors and the expected number in the regional population, standardized by age and calendar year.",{"name":70,"@type":61,"acceptedAnswer":71},"What major findings were reported regarding sex differences?",{"text":72,"@type":64},"Synchronous cancer risk increased in both males and females, while metachronous cancer excess risk showed distinct sex-specific site patterns. The study also reports higher overall metachronous risk in females in the first years after melanoma diagnosis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378001,1790293897,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","TYPE Original Research PUBLISHED 16 June 2023  \nDOI 10.3389/fpubh.2023.1195458  \nOPEN ACCESS  \nEDITED BY  \nP. S. Rakesh,  \nThe Union South East Asia Office, India  \nREVIEWED BY  \nGiuseppe Broggi, University of Catania, Italy Aswathy Sreedevi,  \nAmrita Vishwa Vidyapeetham University, India Teena Mary Joy,  \nAmrita Vishwa Vidyapeetham University, India  \n*CORRESPONDENCE  \nAlessandra Buja  \n [alessandra.buja@unipd.it](alessandra.buja@unipd.it)  \nRECEIVED 28 March 2023  \nACCEPTED 30 May 2023  \nPUBLISHED 16 June 2023  \nCITATION  \nGuzzinati S, Buja A, Grotto G, Zorzi M, Manfredi M, Bovo E, Del Fiore P, Tropea S, Dall'Olmo L, Rossi CR, Mocellin S and Rugge M (2023) Synchronous and metachronous multiple primary cancers in melanoma survivors: a gender perspective.  \nFront. Public Health 11:1195458 .  \ndoi: 10.3389/fpubh.2023.1195458  \nCOPYRIGHT  \n© 2023 Guzzinati, Buja, Grotto, Zorzi, Manfredi, Bovo, Del Fiore, Tropea, Dall’Olmo, Rossi, Mocellin and Rugge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nSynchronous and metachronous multiple primary cancers in melanoma survivors: a gender perspective  \nStefano Guzzinati 1, Alessandra Buja 2*, Giulia Grotto 2, Manuel Zorzi 1, Mariagiovanna Manfredi 2, Eleonora Bovo 1, Paolo Del Fiore3, Saveria Tropea3, Luigi Dall'Olmo3, 4, Carlo R. Rossi4, Simone Mocellin3, 4 and Massimo Rugge 1, 5  \n1Veneto Tumor Registry, Azienda Zero, Padua, Italy, 2 Department of Cardiac, Thoracic and Vascular Sciences, and Public Health, University of Padua, Padua, Italy, 3Soft-Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy, 4 Department of Surgery, Oncology and Gastroenterology-DISCOG, University of Padua, Padua, Italy, 5 Department of Medicine-DIMED, Pathology and Cytopathology Unit, University of Padua, Padua, Italy  \nBackground: Long-term survivors of cutaneous malignant melanoma (CMM) risk subsequent malignancies due to both host-related and environmental risk factors. This retrospective population-based study differentially assesses the risk of synchronous and metachronous cancers in a cohort of CMM survivors stratified by sex.  \nMethods: The cohort study (1999–2018) included 9,726 CMM survivors (M=4,873, F=4,853) recorded by the cancer registry of all 5,000,000 residents in the Italian Veneto Region. By excluding subsequent CMM and non-CMM skin cancers, the incidence of synchronous and metachronous malignancies was calculated according to sex and tumor site, standardizing for age and calendar year. The Standardized Incidence Ratio (SIR) was calculated as the ratio between the number of subsequent cancers among CMM survivors and the expected number of malignancies among the regional population.  \nResults: Irrespective of the site, the SIR for synchronous cancers increased in both sexes (SIR=1.90 in males and 1.73 in females) . Both sexes also demonstrated an excess risk for synchronous kidney/urinary tract malignancies (SIR=6.99 in males and 12.11 in females), and women had an increased risk of synchronous breast cancer (SIR=1 .69) . CMM male survivors featured a higher risk of metachronous thyroid (SIR=3 . 51, 95% CI [1 . 87, 6.01]), and prostate (SIR=1 .35, 95% CI [1 . 12, 1.61]) malignancies. Among females, metachronous cancers featured higher SIR values than expected: kidney/urinary tract (SIR=2 . 27, 95% CI [1 . 29, 3.68]), non-Hodgkin’s lymphoma (SIR=2 .06, 95% CI [1 . 24, 3. 21]), and breast (SIR=1 .46, 95% CI [1 . 22, 1.74]) . Females had an overall increased risk of metachronous cancers in the first 5years after CMM diagnosis (SIR=1.54 at 6–11","cbCaig3eBMgR56EB","https://ap.wps.com/l/cbCaig3eBMgR56EB","pdf",396719,"English","# Introduction\n## Methods\n## Results\n## Conclusion\n## Keywords","[{\"question\":\"What distinguishes synchronous and metachronous multiple primary cancers in melanoma survivors?\",\"answer\":\"Synchronous cancers occur concurrently with the melanoma-related diagnosis timeframe, while metachronous cancers arise later. The study quantifies both types by comparing observed subsequent cancers with expected rates.\"},{\"question\":\"How was the risk of subsequent cancers measured?\",\"answer\":\"The study calculates Standardized Incidence Ratios (SIRs) as the ratio between observed subsequent cancers among melanoma survivors and the expected number in the regional population, standardized by age and calendar year.\"},{\"question\":\"What major findings were reported regarding sex differences?\",\"answer\":\"Synchronous cancer risk increased in both males and females, while metachronous cancer excess risk showed distinct sex-specific site patterns. The study also reports higher overall metachronous risk in females in the first years after melanoma diagnosis.\"}]","Synchronous and metachronous multiple primary cancers in melanoma survivors: a gender perspective | PDF",1790227960,18]