[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381033-105":59,"doc-detail-381033-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","synbiotics-as-supplemental-therapy-for-the-alleviation-of-chemotherapy-associated-symptoms-in-patients-with-solid-tumours","Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours","","Chemotherapy remains the primary treatment for most cancer patients, yet it commonly weakens defenses and increases infection-related complications such as sepsis, mucositis, colitis, and diarrhoea. Multiple nutritional strategies have been investigated, but routine clinical approval is lacking. Restoring gut microbiota is one promising route because the microbiome supports immune function, metabolism, and molecular regulation. Chemotherapy damages the gut mucosal barrier, reducing microbiota, and probiotics—and especially synbiotics (probiotics plus prebiotics)—may help counter chemotherapy-associated side effects.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synbiotics-as-supplemental-therapy-for-the-alleviation-of-chemotherapy-associated-symptoms-in-patients-with-solid-tumours/381033/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synbiotics-as-supplemental-therapy-for-the-alleviation-of-chemotherapy-associated-symptoms-in-patients-with-solid-tumours/381033.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are chemotherapy-associated symptoms common in cancer patients?","Question",{"text":113,"@type":114},"Chemotherapy can make patients more prone to infections and complications, including sepsis, mucositis, colitis, and diarrhoea.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How might gut microbiota restoration help reduce chemotherapy side effects?",{"text":118,"@type":114},"Gut microbiota supports immune system function, metabolism, and molecular regulation; chemotherapy erodes the gut mucosal layer, causing microbiota loss, so restoring the microbiota may help.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the difference between probiotics and synbiotics in this context?",{"text":122,"@type":114},"Probiotics are “good” bacteria that may provide health benefits in appropriate amounts, while synbiotics combine probiotics with prebiotics and may offer better benefits than probiotics alone.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381033,1790318414,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","nutrients   \nReview  \nSynbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours  \nNeeraj K. Singh 1, Jeffrey M. Beckett 1, Krishnakumar Kalpurath 1,2, Muhammad Ishaq 1, Tauseef Ahmad 1 and Rajaraman D. Eri 1,3, *  \n1 School of Health Sciences, University of Tasmania, Newnham, Launceston 7248, Australia  \n2 Mersey Community Hospital, Latrobe 7307, Australia  \n3 School of Science, STEM College, RMIT University, Melbourne 3083, Australia  \n* Correspondence: [rajaraman.eri@rmit.edu.au](rajaraman.eri@rmit.edu.au)  \nCitation: Singh, N.K.; Beckett, J.M.; Kalpurath, K.; Ishaq, M.; Ahmad, T.; Eri, R.D. Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours. Nutrients 2023, 15, 1759 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)nu15071759  \nAcademic Editor: Antonio Brunetti  \nReceived: 28 February 2023  \nRevised: 27 March 2023  \nAccepted: 30 March 2023  \nPublished: 4 April 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nAbstract: Chemotherapy is still the first line of treatment for most cancer patients. Patients receiving chemotherapy are generally prone to infections, which result in complications, such as sepsis, mucositis, colitis, and diarrhoea. Several nutritional approaches have been trialled to counter the chemotherapy-associated side effects in cancer patients, but none have yet been approved for routine clinical use. One of the approaches to reduce or avoid chemotherapy-associated complications is to restore the gut microbiota. Gut microbiota is essential for the healthy functioning of the immune system, metabolism, and the regulation of other molecular responses in the body. Chemotherapy erodes the mucosal layer of the gastrointestinal tract and results in the loss of gut microbiota. One of the ways to restore the gut microbiota is through the use of probiotics. Probiotics are the `good' bacteria that may provide health benefits if consumed in appropriate amounts. Some studies have highlighted that the consumption of probiotics in combination with prebiotics, known as synbiotics, may provide better health benefits when compared to probiotics alone. This review discusses the different nutritional approaches that have been studied in an attempt to combat chemotherapy-associated side effects in cancer patients with a particular focus on the use of pre-, pro-and synbiotics.  \nKeywords: cancer; chemotherapy; probiotics; prebiotics; synbiotics  \n1. Introduction  \nCancer is the leading cause of mortality in Australia, leading to approximately 50,000 deaths in 2020 . Currently, there are more than 1 million people in Australia who have been diagnosed with cancer at some point in time. It was estimated that around 150,000 new cases would be diagnosed in Australia in 2020 [1] . The World Health Organization (WHO) has estimated that cancer diagnoses will increase by 45% between 2008 and 2030 . Major causes of cancer involve heavy smoking, poor diet, physical inactivity, and environmental pollutions. In 2018, the most common cancers diagnosed globally were lung cancer (2.09 million), followed by colorectal (2.09 million), prostate (1.28 million), skin (1.04 million), and then stomach cancer (1.03 million) . The financial burden of cancer is enormous and the global burden in 2010 was estimated to be approximately USD 1. 16 trillion [2] .  \nCancer is defined as the uncontrolled growth of cells in the body and, clinically, is termed as a malignant neoplasm. Cancer starts via genetic and epigenetic variations that result in the unlimited multiplication of cells which e","cbCaivn5jocya5QI","https://ap.wps.com/l/cbCaivn5jocya5QI","pdf",786693,17,"English","# Abstract\n# 1. Introduction\n# 2. Cancer Chemotherapy\n# 3. Synbiotics as a Potential Strategy (Pro- and Prebiotics)\n# Keywords","[{\"question\":\"Why are chemotherapy-associated symptoms common in cancer patients?\",\"answer\":\"Chemotherapy can make patients more prone to infections and complications, including sepsis, mucositis, colitis, and diarrhoea.\"},{\"question\":\"How might gut microbiota restoration help reduce chemotherapy side effects?\",\"answer\":\"Gut microbiota supports immune system function, metabolism, and molecular regulation; chemotherapy erodes the gut mucosal layer, causing microbiota loss, so restoring the microbiota may help.\"},{\"question\":\"What is the difference between probiotics and synbiotics in this context?\",\"answer\":\"Probiotics are “good” bacteria that may provide health benefits in appropriate amounts, while synbiotics combine probiotics with prebiotics and may offer better benefits than probiotics alone.\"}]","Synbiotics as Supplemental Therapy for the Alleviation of Chemotherapy-Associated Symptoms in Patients with Solid Tumours | PDF",1790243234,43]