[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-433792-105":59,"doc-detail-433792-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","sweet-relief-the-role-of-glucopuncture-in-neuropathic-pain-management","Sweet relief: the role of glucopuncture in neuropathic pain management","","Neuropathic pain remains a major challenge in pain management because of complex mechanisms and incomplete responses to conventional treatments, which can also cause adverse effects. Glucopuncture using 5% glucose in water (D5W) delivered intradermally, subcutaneously, fascially, or perineurally is emerging as a minimally invasive and generally safe option. Proposed mechanisms include TRPV1 modulation, reduced neurogenic inflammation, and stabilized C-fiber excitability. Evidence from case reports to randomized trials suggests meaningful, sustained analgesia across selected neuropathic conditions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sweet-relief-the-role-of-glucopuncture-in-neuropathic-pain-management/433792/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sweet-relief-the-role-of-glucopuncture-in-neuropathic-pain-management/433792.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is neuropathic pain difficult to manage with conventional treatments?","Question",{"text":113,"@type":114},"Neuropathic pain has complex pathophysiology and limited treatment options, so conventional approaches often provide only partial relief and may carry adverse-effect risks.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What is glucopuncture in this review and what solution is typically used?",{"text":118,"@type":114},"Glucopuncture refers to intradermal or subcutaneous injection of low-concentration glucose solution, most commonly 5% glucose in water (D5W).",{"name":120,"@type":111,"acceptedAnswer":121},"Which mechanisms are proposed for glucopuncture’s pain-relieving effects?",{"text":122,"@type":114},"The review proposes transient receptor potential vanilloid 1 (TRPV1) modulation, suppression of neurogenic inflammation, and stabilization of C-fiber excitability.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433792,1790705353,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Korean J Pain 2026;39(1):59-72 [https://doi.org/10.3344/kjp.25318](https://doi.org/10.3344/kjp.25318)[ ](https://doi.org/10.3344/kjp.25318)[pISSN 2005-9159](pISSN 2005-9159), eISSN 2093-0569  \n| \u003Cbr>Review Article\u003Cbr>Sweet relief: the role of glucopuncture inneuropathic pain management\u003Cbr>Minhye Chang1, Francis Sahngun Nahm1,2, and Eun Joo Choi1,2\u003Cbr>1 Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 2 Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea |  |\n| --- | --- |\n| ABSTRACT\u003Cbr>Neuropathic pain remains a major challenge in pain management because of its complex mechanisms and suboptimal response to conventional treatments, which often provide incomplete relief and carry the risk of adverse effects. Injections of 5% glucose in water (D5W) delivered via intradermal, subcutaneous, fascial, or perineural glucopuncture have emerged as a minimally invasive and safe therapeutic option. Although the exact mechanism has not been fully elucidated, the proposed pathways include transient receptor potential vanilloid 1 modulation, suppression of neurogenic inflammation, and stabilization of C-fiber excitability. Clinical studies, ranging from case reports to randomized controlled trials, have suggested the efficacy of this approach in postherpetic neuralgia, entrapment neuropathies, chronic tendinopathies, and fascial pain, with minimal complications. Unlike prolotherapy, glucopuncture uses isotonic glucose (D5W), and primarily exerts neuromodulatory rather than regenerative effects. Current evidence, while limited, indicates meaningful and sustained pain relief in selected neuropathic conditions with a favorable safety profile and low procedural complexity. This review outlines key mechanisms, clinical outcomes, differences between related interventions, and clinical considerations.\u003Cbr>Keywords: Glucose; Injections, Intradermal; Injections, Subcutaneous; Nerve Compression Syndromes; Neuralgia, Postherpetic; Neurogenic Inflammation; Pain Management; Prolotherapy. |  |\n| INTRODUCTION | pain, including medications such as anticonvulsants and antidepressants, as well as nerve blocks using local |\n| Neuropathic pain presents a significant challenge in pain | anesthetics or corticosteroids, often provides only partial |\n| management because of its complex pathophysiology | relief and carries the risk of adverse effects. These include |\n| and limited treatment options. Neuropathic pain affects | rare but serious systemic toxicity from local anesthet- |\n| approximately 7%–10% of the general population and sig- | ics; corticosteroid-related complications such as axonal |\n| nificantly impairs quality of life [1] . It is caused by dam- | and myelin injury, tissue atrophy, tendon rupture, and |\n| age to or dysfunction of the somatosensory system, and | steroid-induced flare reactions; and inflammatory re- |\n| results in symptoms such as paresthesia, hyperalgesia, | sponses such as crystal-induced synovitis [2] . |\n| and allodynia. Conventional management of neuropathic | Glucopuncture, defined as the intradermal or subcu- |\n\nReceived August 26, 2025; Revised October 10, 2025; Accepted October 13, 2025 Handling Editor: Kyung-Joon Lim  \nCorrespondence: Eun Joo Choi  \nDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundanggu, Seongnam 13620, Korea  \nTel: +82-31-787-7499, Fax: +82-31-787-4063, [E-mail:](E-mail: ejchoi@snubh.org)[ ejchoi@snubh.org](E-mail: ejchoi@snubh.org)  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by-nc/4.0](licenses/by-nc/4.0)), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nCo","cbCaikOS4Gkzu8dG","https://ap.wps.com/l/cbCaikOS4Gkzu8dG","pdf",2713494,14,"English","# Abstract\n# Introduction\n## Burden and limitations of conventional neuropathic pain treatments\n## Glucopuncture concept and proposed mechanisms\n## Clinical rationale and treatment approaches","[{\"question\":\"Why is neuropathic pain difficult to manage with conventional treatments?\",\"answer\":\"Neuropathic pain has complex pathophysiology and limited treatment options, so conventional approaches often provide only partial relief and may carry adverse-effect risks.\"},{\"question\":\"What is glucopuncture in this review and what solution is typically used?\",\"answer\":\"Glucopuncture refers to intradermal or subcutaneous injection of low-concentration glucose solution, most commonly 5% glucose in water (D5W).\"},{\"question\":\"Which mechanisms are proposed for glucopuncture’s pain-relieving effects?\",\"answer\":\"The review proposes transient receptor potential vanilloid 1 (TRPV1) modulation, suppression of neurogenic inflammation, and stabilization of C-fiber excitability.\"}]","Sweet relief: the role of glucopuncture in neuropathic pain management | PDF",1790665513,35]