[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-452602-105":59,"doc-detail-452602-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","suzetrigine-for-the-treatment-of-acute-pain-reply","Suzetrigine for the Treatment of Acute Pain - Reply","","Reply addressing commentary on phase 3 randomized clinical trials of suzetrigine for moderate-to-severe acute pain after abdominoplasty and bunionectomy. The response highlights strong representation of Black/African American and Hispanic/Latino participants and reports that suzetrigine efficacy versus placebo, using SPID48 as the primary endpoint, was generally consistent across racial and ethnic subgroups. It further describes similar SPID48 outcomes by sex, arguing sex does not significantly alter analgesic efficacy, while emphasizing a consistent safety profile.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/suzetrigine-for-the-treatment-of-acute-pain-reply/452602/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/suzetrigine-for-the-treatment-of-acute-pain-reply/452602.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What endpoint was used to compare suzetrigine with placebo?","Question",{"text":112,"@type":113},"The primary endpoint was SPID48, measured as the sum of the pain intensity difference on the numeric pain rating scale from 0 to 48 hours.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Were suzetrigine efficacy results consistent across racial and ethnic subgroups?",{"text":117,"@type":113},"The reply states that ad hoc analyses showed efficacy compared with placebo was generally consistent across racial and ethnic subgroups, despite subgroup differences not being the original study design goal.",{"name":119,"@type":110,"acceptedAnswer":120},"Did sex influence suzetrigine’s analgesic efficacy?",{"text":121,"@type":113},"The reply reports that SPID48 was similar in male and female participants in the bunionectomy study and that findings from McCoun et al. also indicate sex does not significantly impact analgesic efficacy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},452602,1791101367,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39,"preview_page_count":4},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","LETTERS TO THE EDITOR  \nmoderate-to-severe acute pain: Two phase 3 randomized clinical trials. Anesthesiology 2025; 142:1085–  \n99. doi:10 . 1097/aln.0000000000005460  \n2. Rathmell JP, Clark JD, Eisenach JC: Suzetrigine: First in a new class of nonopioid analgesics for acute pain. Anesthesiology 2025; 142:989–91 . doi:10.1097/aln.0000000000005465  \n3. Anaya LR, Toledo P, Alvarez JC Jr, Delgado A, Brown M,Viera H:The effect of Medicare coverage on access to bunionectomies among the elderly population: A secret shopper study. J Int Foot Ankle Foundation 2023; 2. Available at: [https://www.internationalfoot](https://www.internationalfoot)[ankle.org/journal/index.php/JIFAF/article/view/75](ankle.org/journal/index.php/JIFAF/article/view/75) . Accessed November 22, 2025.  \n4. Al-Sumaih I, Donnelly M, O’Neill C: Sociodemographic characteristics of patients and their use of post-bariatric contouring surgery in the US. BMC Health Serv Res 2022; 22:308 . doi:10.1186/s12913-022-07692-1  \n5. Wandner LD, Scipio CD, Hirsh AT, Torres CA, Robinson ME: The perception of pain in others: How gender, race, and age influence pain expectations. J Pain 2012; 13:220–7 . doi:10.1016/j.jpain.2011.10.014  \n6. Pisanu C, Franconi F, Gessa GL, et al.: Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis. Pharmacol Res 2019;  \n148:104447. doi:10.1016/j.phrs.2019.104447  \n7. Pletcher MJ, Kertesz SG, Kohn MA, Gonzales R: Trends in opioid prescribing by race/ethnicity for patients seeking care in US emergency departments. JAMA 2008; 299:70–8 . doi:10.1001/jama.2007.64  \n8. Singhal A, Tien YY, Hsia RY: Racial-ethnic disparities in opioid prescriptions at emergency department visits for pain. Acad Emerg Med 2016; 23:478–85 . doi:10.1371/journal.pone.0159224  \n9. Meghani SH, Byun E, Gallagher RM: Time to take stock: A meta-analysis and systematic review of analgesic treatment disparities for pain in the United States. Pain Med 2012; 13:150–74 . doi:10.1111/j.1526-4637.2011.01310.x  \n10. MilamAJ,Youssef MR, Ugochukwu K, et al.:Applying a health equity lens to intraoperative opioid administration and postoperative pain. Anesth Analg 2024;  \n139:675–8 . doi:10 . 1213/ANE.0000000000006968  \n(Accepted for publication October 17, 2025. Published online first on December 11, 2025.)  \n Suzetrigine for the Treatment of Acute Pain:  \nReply  \nIn Reply:  \nWe thank Milam et al., Siddiqui et al., and Xiang et al.  \nfor their commentary.1–3  \nThe phase 3 randomized controlled trials of suzetrigine for moderate-to-severe acute pain after abdominoplasty and bunionectomy had significant representation of Black/African American (abdominoplasty, 299 of 1,118; bunionectomy, 260 of 1,073) and Hispanic/Latino participants (abdominoplasty, 380 of 1,118; bunionectomy, 364 of 1,073).4 While our studies were not designed to detect differences within subgroups, ad hoc analyses demonstrated that the efficacy of suzetrigine compared to placebo (measured by sum of the pain intensity difference in numeric pain rating scale from 0 to 48 h [SPID48], primary endpoint) was generally consistent across racial and ethnic subgroups. In a study by McCoun et al. , involving diverse surgical and nonsurgical pain conditions, participants’perception of suzetrigine’s effectiveness in managing pain atthe end of treatment (assessed by the proportion of participants reporting good, very good, or excellent pain relief) was similar among White (84%, 180 of 214), Black/ African American (79%, 27 of 34), and Hispanic/Latino (83%, 90 of 108) participants.5 With regard to sex, our bunionectomy study, which enrolled a sufficient number of males, showed that SPID48 was similar in male and female participants.4 Further, suzetrigine’s effectiveness was similar in male (80%, 66 of 83) and female (85%, 147 of 173) participants in the McCoun et [al.](al. study.5 Literature)[ study.](al. study.5 Literature)[5](al. study.5 Literature)[ Literature](al. study.5 Literature)[ ](al. stu","cbCaifYCjciUJWi1","https://ap.wps.com/l/cbCaifYCjciUJWi1","pdf",238133,"English","# Reply\n## Trial population and subgroup consistency\n## Sex-based findings and safety profile\n## Clinical meaningfulness and study context","[{\"question\":\"What endpoint was used to compare suzetrigine with placebo?\",\"answer\":\"The primary endpoint was SPID48, measured as the sum of the pain intensity difference on the numeric pain rating scale from 0 to 48 hours.\"},{\"question\":\"Were suzetrigine efficacy results consistent across racial and ethnic subgroups?\",\"answer\":\"The reply states that ad hoc analyses showed efficacy compared with placebo was generally consistent across racial and ethnic subgroups, despite subgroup differences not being the original study design goal.\"},{\"question\":\"Did sex influence suzetrigine’s analgesic efficacy?\",\"answer\":\"The reply reports that SPID48 was similar in male and female participants in the bunionectomy study and that findings from McCoun et al. also indicate sex does not significantly impact analgesic efficacy.\"}]","Suzetrigine for the Treatment of Acute Pain - Reply | PDF",1790737463]