[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-385134-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-385134-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","survivin-expression-as-a-prognostic-marker-for-breast-cancer","Survivin expression as a prognostic marker for breast cancer","","Breast cancer biomarkers are urgently needed to support earlier diagnosis and treatment decisions. This cross-sectional study examined survivin gene expression in paraffin-embedded breast tumor samples and evaluated its relationship with patients’ clinical characteristics. Among 100 women over 30 with anatomopathologically confirmed breast cancer, survivin expression was quantified by polymerase chain reaction, then analyzed against prognostic receptor status and other markers. Results link survivin expression to absent estrogen and progesterone receptor expression.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/survivin-expression-as-a-prognostic-marker-for-breast-cancer/385134/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/survivin-expression-as-a-prognostic-marker-for-breast-cancer/385134.png","ImageObject",300,407,{"name":42,"@type":43},"Adam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the objective of this study?","Question",{"text":63,"@type":64},"To verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with patients’ clinical characteristics.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was survivin expression measured?",{"text":68,"@type":64},"Survivin gene expression was assessed by quantitative polymerase chain reaction using paraffin-embedded tumor samples.",{"name":70,"@type":61,"acceptedAnswer":71},"What relationship was found between survivin expression and hormone receptors?",{"text":72,"@type":64},"Survivin expression was associated with lack of estrogen and progesterone receptor expression, being higher when estrogen receptor and progesterone receptor labeling was absent.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},385134,1790644873,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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expression as a prognostic marker for breast cancer  \nPatricia Quidute1 , Ricardo Quidute1 , Matheus Moreira Perez1 , Edimar Cristiano Pereira2 , Glaucia Luciano daVeiga1 , Beatriz da Costa Aguiar Alves1 , Fernando Luiz Affonso Fonseca1,2*   \nSUMMARY  \nOBJECTIVE: Duetothe speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis. As survivin plays a fundamental role in the evasion of apoptosis in tumor cells, the aim of this study was to verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with the clinical characteristics of the patients. METHODS: This is a cross-sectional study, for which 100 tumor samples were obtained from cancer patients treated throughout the year 2019 at Instituto de Mama do Cariri (Juazeiro do Norte, in the state of Ceará) . This study included women over 30 years old who had confirmed breast cancer through anatomopathological examination but excluded those with non-neoplastic breast comorbidities, other neoplasms, or chronic diseases. Survivin gene expression was assessed by quantitative polymerase chain reaction.  \nRESULTS: The expression of survivin is associated with the lack of expression of estrogen (p=0 .027) and progesterone (p>0 .0005) receptors. It means that survivin expression is higher in patients in which labeling was absent for estrogen receptor and progesterone receptor.  \nCONCLUSION: Our data reinforce that survivin expression is higher in estrogen receptor-patients, thus representing an additional prognostic tool.  \nKEYWORDS: Survivin. Breast neoplasm. Prognosis. Paraffin embedding. Hormone receptors.  \nINTRODUCTION  \nCancer is highly prevalent worldwide, with breast cancer being the second most common in women 1 . Due to the speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis and quickly initiate treatment, thus increasing the chances of achieving a cure for the patient.  \nCurrently, survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, has been the subject of several studies involving cancer2 . This 16.5 kDa protein, encoded by the BIRC5 gene, was cloned for the first time in 1997 by Ambrosini et al.3 and is detected in many cases of malignant tumors4, but not in healthy tissue samples, therefore directly relating its presence to oncogenesis2,4,5 .  \nSurvivin participates in several biological pathways4-6, but one of the main pathways in which this protein is expressed is in escape from apoptosis. Apoptosis, i.e., programmed cell death, can be initiated by extrinsic and intrinsic cell expression pathways7; in the extrinsic pathway, an external agent (i.e., radiotherapy, chemotherapy, and so on) stimulates p53, an apoptosis-linked transcription factor that regulates a number of  \nother pro-apoptotic genes that lead to cell death2. Survivin acts directly to inactivate the apoptosis cascade. Thus, p53 acts antagonistically to the anti-apoptotic action of surviving2,4,6; in this way, research is being carried out to evaluate how the inactivation of survivin would be an effective form of treatment inpatients with metastatic cancer2. In cells that are being signaled for apoptosis, survivin is more expressed and released into the cytosol, preventing the activation of caspases, and thus, inhibiting apoptosis2,5 .  \nThe intrinsic pathway, in turn, is initiated by signals from mitochondria, a cytoplasmic organelle in eukaryotic cells. After intrinsic stimulation, cytochrome-C and Smac/DIABLO produced in the mitochondria form the apoptosome that activates caspase-97. Then caspase-9 activates other caspases that induce cellular apoptosis. In mammals, IAP proteins inhibit apoptosis by indir","cbCaiiZszVdbB7Ex","https://ap.wps.com/l/cbCaiiZszVdbB7Ex","pdf",258430,"English","# Summary\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Survivin and apoptosis\n# Methods\n## Patients\n## Tumor samples","[{\"question\":\"What was the objective of this study?\",\"answer\":\"To verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with patients’ clinical characteristics.\"},{\"question\":\"How was survivin expression measured?\",\"answer\":\"Survivin gene expression was assessed by quantitative polymerase chain reaction using paraffin-embedded tumor samples.\"},{\"question\":\"What relationship was found between survivin expression and hormone receptors?\",\"answer\":\"Survivin expression was associated with lack of estrogen and progesterone receptor expression, being higher when estrogen receptor and progesterone receptor labeling was absent.\"}]","Survivin expression as a prognostic marker for breast cancer | PDF",1790266880,13]