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Few studies describe PEUGIC survival. This population-based retrospective analysis compares survival in PEUGIC patients with upper gastrointestinal cancer (UGIC) patients diagnosed without prior endoscopy. Methods UGIC diagnosed in England between 2009 and 2018 were categorized as detected UGIC or PEUGIC (6–12, 12–18, 18–24, 24–36 months) and analyzed using Kaplan–Meier curves and stratifications by Barrett’s esophagus and histology.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/survival-outcomes-for-post-endoscopy-upper-gastrointestinal-cancer-in-england/354625/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/survival-outcomes-for-post-endoscopy-upper-gastrointestinal-cancer-in-england/354625.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How is PEUGIC defined in this study?","Question",{"text":113,"@type":114},"PEUGIC is defined as upper gastrointestinal cancer diagnosed 6–36 months after a prior index endoscopy in which cancer was not diagnosed.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What data and study design were used to assess survival outcomes?",{"text":118,"@type":114},"The study used a population-based retrospective survival analysis of UGIC patients diagnosed in England between January 2009 and December 2018.",{"name":120,"@type":111,"acceptedAnswer":121},"Why did PEUGIC show better survival than detected UGIC?",{"text":122,"@type":114},"The apparent improved survival in PEUGIC versus detected UGIC was largely attributed to surveillance for pre-existing Barrett’s esophagus, while epidemiological biases such as selection, lead time, and immortal time should also be considered.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},354625,1790231067,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Article published online: 2026-06-12  \nOriginal article  \nSurvival outcomes for post-endoscopy upper gastrointestinal cancer in England  \nGRAPHICAL ABSTRACT  \nSurvival outcomes for  \npost-endoscopy upper gastointestinal cancer (PEUGIC)  \nGI, gastrointestinal.  \nThe apparent improved survival in PEUGIC vs. detected cancer is largely due to Barrett's esophagus surveillance  \nAuthors  \nAmar Srinivasa1,2 , Felicity Evison3, Roland Valori4, Eva J. A. Morris5, Nigel Trudgill1,6  \nInstitutions  \n1 Department of Gastroenterology, Sandwell and West Birmingham NHS Trust, West Bromwich, United Kingdom  \n2 Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom  \n3 Data Science Team, Research Development and Innovation, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom  \n4 Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom  \n5 Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom  \n6 Department of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom  \nreceived 7.11.2025  \naccepted after revision 13.4.2026 published online 12.6.2026  \nBibliography  \nEndoscopy ; 58: 833–847  \nDOI 10.1055/a-2858-6925  \nISSN 0013-726X  \n© 2026. The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ([https://creativecommons.org/licenses/by-nc-nd/4.0/](https://creativecommons.org/licenses/by-nc-nd/4.0/))  \nGeorg Thieme Verlag KG, Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany  \n Supplementary Material  \nSupplementary Material is available at [https://doi.org/10.1055/a-2858-6925](https://doi.org/10.1055/a-2858-6925)  \n Scan this QR-Code for the author commentary.  \nSrinivasa Amar et al. Survival outcomes for… Endoscopy ; 58: 833–847 | © 2026. The Author(s) . 833  \nCorresponding author  \nNigel Trudgill, MD, Department of Gastroenterology, Sandwell and West Birmingham NHS Trust, Sandwell General Hospital, Hallam Street, West Bromwich B71 4HJ, United Kingdom  \n[nigel.trudgill@nhs. net](nigel.trudgill@nhs. net)  \nABSTRACT  \nBackground Post-endoscopy upper gastrointestinal cancer (PEUGIC) is defined as cancer diagnosed 6–36 months after a prior index endoscopy during which cancer was not diagnosed. Few studies have examined PEUGIC survival. We describe survival in PEUGIC patients compared with upper gastrointestinal cancer (UGIC) patients who did not undergo endoscopy without a cancer diagnosis prior to their diagnosis.  \nMethods This was a population-based retrospective survival analysis of UGIC patients diagnosed between January 2009 and December 2018 in England. Patients were categorized into “detected UGIC” (without prior endoscopy) and “PEUGIC” diagnosed 6–12, 12–18, 18–24, or 24–36 months after index endoscopy. PEUGIC survival was ana-  \nlyzed according to pre-existing Barrett ’s esophagus (BE), esophageal cancer histological, and gastric cancer. Kaplan–Meier all-cause survival curves investigated survival from both diagnosis and index endoscopy date.  \nResults 98710 UGIC patients (9068 PEUGIC [9 . 2%]) were studied. Pre-existing BE was recorded for 9975 UGIC patients (10.1%), including 2583 PEUGIC (25.9%) . PEUGIC survival was better than detected UGIC survival but the difference decreased as time between index endoscopy and diagnosis increased. Patients with pre-existing BE and PEUGIC had much better survival, with more stage 1 cancer (39.5% versus 8.4% for PEUGIC without BE; P\u003C0.001) . Survival in PEUGIC and detected UGIC patients was similar when BE patients were excluded. Survival in PEUGIC patients with squamous cell carcinoma and gastric cancer was the same as for detected UGIC.  \n","cbCaivbdVkGRk7qs","https://ap.wps.com/l/cbCaivbdVkGRk7qs","pdf",1673694,15,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"How is PEUGIC defined in this study?\",\"answer\":\"PEUGIC is defined as upper gastrointestinal cancer diagnosed 6–36 months after a prior index endoscopy in which cancer was not diagnosed.\"},{\"question\":\"What data and study design were used to assess survival outcomes?\",\"answer\":\"The study used a population-based retrospective survival analysis of UGIC patients diagnosed in England between January 2009 and December 2018.\"},{\"question\":\"Why did PEUGIC show better survival than detected UGIC?\",\"answer\":\"The apparent improved survival in PEUGIC versus detected UGIC was largely attributed to surveillance for pre-existing Barrett’s esophagus, while epidemiological biases such as selection, lead time, and immortal time should also be considered.\"}]","Survival outcomes for post-endoscopy upper gastrointestinal cancer in England | PDF",1790112635,38]