[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329118-105":59,"doc-detail-329118-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","surveillance-for-metachronous-cancers-after-endoscopic-resection-of-esophageal-squamous-cell-carcinoma","Surveillance for metachronous cancers after endoscopic resection of esophageal squamous cell carcinoma","","Literature on surveillance after endoscopic resection of esophageal squamous cell carcinoma reviews current practice and future perspectives. Standardized mortality and incidence ratio analyses show elevated risks for metachronous cancers in the oral cavity, pharynx, larynx, and lungs compared with the general population, indicating a need for risk stratification. Predictors include multiple Lugol-voiding lesions, multiple dilated vascular foci, younger age, and high mean corpuscular volume. Endoscopic surveillance scheduled 6–12 months post-resection is effective, with over 90% of metachronous esophageal SCCs treatable by minimally invasive modalities; narrow-band imaging and emerging AI-assisted detection and high-risk mucosa ablation are highlighted.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/surveillance-for-metachronous-cancers-after-endoscopic-resection-of-esophageal-squamous-cell-carcinoma/329118/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/surveillance-for-metachronous-cancers-after-endoscopic-resection-of-esophageal-squamous-cell-carcinoma/329118.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is surveillance needed after endoscopic resection of esophageal squamous cell carcinoma?","Question",{"text":112,"@type":113},"Surveillance is important because patients have an elevated risk of metachronous cancers in multiple upper aerodigestive and lung sites compared with the general population, and early detection can enable successful treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors have been identified as predictors of metachronous esophageal squamous cell carcinomas?",{"text":117,"@type":113},"Reported predictors include multiple Lugol-voiding lesions, multiple foci of dilated vascular areas, younger age, and high mean corpuscular volume.",{"name":119,"@type":110,"acceptedAnswer":120},"What surveillance approach and timing are described after endoscopic resection?",{"text":121,"@type":113},"Practice stratifies risk of metachronous esophageal and head/neck SCCs based on the presence of multiple Lugol-voiding lesions, and endoscopic surveillance is scheduled 6–12 months after resection.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329118,1790440183,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","REVIEW  \nClin Endosc 2024;57:559-570 [https://doi.org/10.5946/ce.2023.263](https://doi.org/10.5946/ce.2023.263)  \n[pISSN: 2234-2400](pISSN: 2234-2400) • eISSN: 2234-2443  \nOpen Access  \nSurveillance for metachronous cancers after endoscopic resection of esophageal squamous cell carcinoma  \nRyu Ishihara  \nDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan  \nThe literature pertaining to surveillance following treatment for esophageal squamous cell carcinoma (SCC) was reviewed and summarized, encompassing the current status and future perspectives. Analysis of the standardized mortality and incidence ratios for these cancers indicates an elevated risk of cancer in the oral cavity, pharynx, larynx, and lungs among patients with esophageal SCC compared to the general population. To enhance the efficacy of surveillance for these metachronous cancers, risk stratification is needed. Various factors, including multiple Lugol-voiding lesions, multiple foci of dilated vascular areas, young age, and high mean corpuscular volume, have been identified as predictors of metachronous SCCs. Current practice involves stratifying the risk of metachronous esophageal and head/neck SCCs based on the presence of multiple Lugol-voiding lesions. Endoscopic surveillance, scheduled 6-12 months post-endoscopic resection, has demonstrated effectiveness, with over 90% of metachronous esophageal SCCs treatable through minimally invasive modalities. Narrow-band imaging emerges as the preferred surveillance method for esophageal and head/neck SCC based on comparative studies of various imaging techniques. Innovative approaches, such as artificial intelligence-assisted detection systems and radiofrequency ablation of high-risk background mucosa, may improve outcomes in patients following endoscopic resection.  \nKeywords: Active surveillance; Endoscopic submucosal dissection; Esophageal squamous cell carcinoma  \nINTRODUCTION  \nEsophageal cancer ranks as the seventh most prevalent cancer and the sixth leading cause of cancer-related mortality globally, with 572,000 new cases and 509,000 deaths in 2018.1 Despite a swift rise in the incidence of esophageal adenocarcinoma in Europe and North America, esophageal squamous cell carcinoma (SCC) remains the predominant histological type, constituting 80% of all esophageal cancers worldwide.1  \nReceived: October 10, 2023 Revised: December 15, 2023  \nAccepted: December 17, 2023  \nCorrespondence: Ryu Ishihara  \nDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan  \nE-mail: [ryu1486@gmail.com](ryu1486@gmail.com)  \n This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nThe overall survival rate for patients with advanced esophageal cancer remains low.2 However, when identified at an early stage, esophageal cancer can be treated successfully through endoscopic resection (ER), surgical resection, or chemoradiotherapy.3,4 ER is a curative approach for esophageal cancers with minimal risk of metastasis,3 employing a technique designed to completely remove the cancerous mucosa by deep submucosal resection. The resected specimen is subsequently used for pathologic diagnosis to stratify the patient’s risk for metastasis. In cases where there is a significant risk of metastasis, additional treatments, such as esophagectomy or chemoradiotherapy, are administered.5,6  \nThis organized treatment strategy has significantly improved the outcome of esophageal cancer after ER.3,7,8 Notable progress in the prognosis of esophageal cancer highlights the importance of surveillance for subsequent disease. This review aims to summarize th","cbCaif66wx6owGdA","https://ap.wps.com/l/cbCaif66wx6owGdA","pdf",2524025,12,"English","# Introduction\n# Literature Search\n# Long-term Survival After ER for Esophageal SCC\n## Risk Stratification for Metachronous Cancers\n## Endoscopic Surveillance Strategies\n## Emerging Technologies and Future Perspectives","[{\"question\":\"Why is surveillance needed after endoscopic resection of esophageal squamous cell carcinoma?\",\"answer\":\"Surveillance is important because patients have an elevated risk of metachronous cancers in multiple upper aerodigestive and lung sites compared with the general population, and early detection can enable successful treatment.\"},{\"question\":\"Which factors have been identified as predictors of metachronous esophageal squamous cell carcinomas?\",\"answer\":\"Reported predictors include multiple Lugol-voiding lesions, multiple foci of dilated vascular areas, younger age, and high mean corpuscular volume.\"},{\"question\":\"What surveillance approach and timing are described after endoscopic resection?\",\"answer\":\"Practice stratifies risk of metachronous esophageal and head/neck SCCs based on the presence of multiple Lugol-voiding lesions, and endoscopic surveillance is scheduled 6–12 months after resection.\"}]","Surveillance for metachronous cancers after endoscopic resection of esophageal squamous cell carcinoma | PDF",1789982598]