[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377121-105":59,"doc-detail-377121-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","surgical-polarimetric-endoscopy-for-the-detection-of-laryngeal-cancer","Surgical polarimetric endoscopy for the detection of laryngeal cancer","","The standard-of-care for laryngeal pathology screening relies on high-definition white-light endoscopy to distinguish suspicious lesions from surrounding healthy tissue, yet color and texture contrast can be insufficient, producing low sensitivity and elevated false-negative rates. A polarimetric approach, surgical polarimetric endoscopy (SPE), measures polarized-light retardance and depolarization to exploit intrinsic optical differences between cancerous and healthy tissues. SPE generates about an order-of-magnitude higher contrast than white-light endoscopy and is validated in patients with squamous cell carcinoma and in support of transoral laser surgery workflows.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/surgical-polarimetric-endoscopy-for-the-detection-of-laryngeal-cancer/377121/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/surgical-polarimetric-endoscopy-for-the-detection-of-laryngeal-cancer/377121.png","ImageObject",300,407,{"name":92,"@type":93},"Melati","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does white-light endoscopy have in laryngeal cancer detection?","Question",{"text":112,"@type":113},"White-light endoscopy may fail to show clear color or texture differences in pre-cancerous and early-cancer stages, while some abnormal-looking tissue may not be cancer. This leads to low sensitivity and non-trivial miss rates.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does surgical polarimetric endoscopy (SPE) improve lesion detection?",{"text":117,"@type":113},"SPE measures differences in polarized-light retardance and depolarization to distinguish cancerous tissue from healthy tissue. It produces about one-order-of-magnitude greater contrast than white-light endoscopy.",{"name":119,"@type":110,"acceptedAnswer":120},"How is SPE supported by tissue and surgical workflow evidence?",{"text":121,"@type":113},"Polarimetric imaging of excised and stained laryngeal tissue links changes in retardance to tissue architectural features. SPE can also complement white-light endoscopy to aid routine transoral laser surgery for removing cancerous lesions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377121,1790844716,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","nature biomedical engineering  \nArticle [https://doi.org/10.1038/s41551-023-01018-0](https://doi.org/10.1038/s41551-023-01018-0)  \nSurgical polarimetric endoscopy for the detection of laryngeal cancer  \nReceived: 6 July 2020  \nAccepted: 23 February 2023  \n\n| Published online: 3 April 2023 |\n| --- |\n|  Check for updates |\n\nJi Qi  1,2,3,4,5,6 , Taranjit Tatla5,7, Eranga Nissanka-Jayasuriya8, Alan Yilun Yuan9, DanailStoyanov  2,3,4  & DanielS. Elson  5,6   \nThe standard-of-care for the detection of laryngeal pathologies involves distinguishing suspicious lesions from surrounding healthy tissue via contrastsin colour and texture captured by white-light endoscopy. However, the technique isinsufficiently sensitive and thus leads to unsatisfactory rates of false negatives. Here we show that laryngeal lesions can be better detected in realtime by taking advantage of differences in the light-polarization properties of cancer and healthy tissues. By measuring differences in polarized-light retardance and depolarization, the technique, which we named ‘surgical polarimetric endoscopy’ (SPE), generates about one-order-of-magnitude greater contrast than white-light endoscopy, and hence allows for the better discrimination of cancerous lesions, as we show with patients diagnosed with squamous cell carcinoma. Polarimetric imaging of excised and stained slices of laryngeal tissue indicated that changes in the retardance of polarized light can be largely attributed to architectural features of the tissue. We also assessed SPEto aid routine transoral laser surgery for the removal of a cancerous lesion, indicating thatSPEcan complement white-light endoscopy for the detection of laryngeal cancer.  \nLaryngeal cancer is oneof the most common malignancies of the upper aerodigestive tract1. Minimally invasive procedures, including endoscopic incisional biopsy and transoral surgery, are widely used for laryngeal cancer diagnosis and intervention, respectively. Surgical endoscopy plays a key role by allowing surgeons to inspect suspicious areas in detail without having to invasively open and expose the larynx, and also to further decide where to biopsy for histopathological examination or where toresectin surgical intervention. The standard-of-care is high-definition white-light endoscopy (WLE), a wide-field optical imaging technique using white-light illumination and red/green/blue (RGB) colour camera imaging of larynx tissue via a surgical endoscope, closely recreating what would be seen by the naked eye. Surgeons rely  \non theWLE colour and texture contrast to differentiate suspicious laryngeal lesions from surrounding normal tissue and then perform the operation. Unfortunately, tumourous lesions—especially those atthe pre-cancerous and early-cancerous stages—may not always present discernible colour or texture differences, while tissue regions with abnormal colour or texture may not always be associated with cancer, leading to unsatisfactory sensitivity (as low as 51.1%) and miss rate2–5. The limitations ofWLE result in inappropriate selection of biopsy targets, or subtotal/unnecessary resection, negatively affecting survival rate or causing additional functional impairment for the patient.  \nMinimally invasive procedures for laryngeal cancer can benefit immensely by introducing complementary surgical endoscopy  \n1Research Center for Humanoid Sensing, Zhejiang Lab, Hangzhou, China. 2Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK. 3Department of Computer Science, University College London, London, UK. 4Centre For Medical Image Computing, University College London, London, UK. 5Hamlyn Centre for Robotic Surgery, Imperial College London, London, UK. 6Department of Surgery and Cancer, Imperial College London, London, UK. 7Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK. 8William Harvey Hospital, East Kent Hospitals University NHS Foundation Trust, London, UK. 9","cbCaioC6luX3EQTz","https://ap.wps.com/l/cbCaioC6luX3EQTz","pdf",4112649,18,"English","# Surgical polarimetric endoscopy (SPE)\n## Limitations of standard-of-care white-light endoscopy (WLE)\n## Polarimetric contrast from retardance and depolarization\n## Validation in patients and relevance to transoral laser surgery","[{\"question\":\"What problem does white-light endoscopy have in laryngeal cancer detection?\",\"answer\":\"White-light endoscopy may fail to show clear color or texture differences in pre-cancerous and early-cancer stages, while some abnormal-looking tissue may not be cancer. This leads to low sensitivity and non-trivial miss rates.\"},{\"question\":\"How does surgical polarimetric endoscopy (SPE) improve lesion detection?\",\"answer\":\"SPE measures differences in polarized-light retardance and depolarization to distinguish cancerous tissue from healthy tissue. It produces about one-order-of-magnitude greater contrast than white-light endoscopy.\"},{\"question\":\"How is SPE supported by tissue and surgical workflow evidence?\",\"answer\":\"Polarimetric imaging of excised and stained laryngeal tissue links changes in retardance to tissue architectural features. SPE can also complement white-light endoscopy to aid routine transoral laser surgery for removing cancerous lesions.\"}]","Surgical polarimetric endoscopy for the detection of laryngeal cancer | PDF",1790223301,45]