[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-354168-105":59,"doc-detail-354168-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","surgical-management-of-32-primary-giant-mediastinal-neoplasms-a-retrospective-single-center-analysis","Surgical management of 32 primary giant mediastinal neoplasms - a retrospective single-center analysis","","Primary giant mediastinal neoplasms are extremely rare, and large-sample evidence remains limited. This retrospective single-center study analyzed consecutive excision cases from January 2019 to December 2023, collecting demographic, surgical, and prognostic data. Thirty-two patients were included: common locations were the prevascular compartment, followed by the visceral and paravertebral compartments. Biopsy and embolization were selectively used. Multidisciplinary planning and complete resection supported prognosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/surgical-management-of-32-primary-giant-mediastinal-neoplasms-a-retrospective-single-center-analysis/354168/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/surgical-management-of-32-primary-giant-mediastinal-neoplasms-a-retrospective-single-center-analysis/354168.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What patient period and design were used to evaluate surgical management?","Question",{"text":112,"@type":113},"A retrospective single-center analysis reviewed consecutive excision surgeries for giant mediastinal neoplasms from January 2019 to December 2023, using collected demographic, surgical, and prognostic data.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which mediastinal compartments were most common among the 32 primary giant neoplasms?",{"text":117,"@type":113},"The prevascular compartment was most prevalent (21 cases), followed by the visceral compartment (9 cases) and the paravertebral compartment (2 cases).",{"name":119,"@type":110,"acceptedAnswer":120},"What surgical or pathological factors were associated with prognosis?",{"text":121,"@type":113},"Pathological classification showed a significant association with prognosis, and R2 resection correlated with significantly poorer survival compared with R0.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},354168,1790269503,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Zhu et al. Journal of Cardiothoracic Surgery (2026) 21:228  \n[https://doi.org/10.1186/s13019-026-03964-7](https://doi.org/10.1186/s13019-026-03964-7)  \nJournal of Cardiothoracic Surgery  \nRESEARCH Open Access  \nSurgical management of 32 primary giant mediastinal neoplasms: a retrospective singlecenter analysis  \nQihang Zhu1,2†, Zhe He2,3†, Jing Zhan1, Xiaojing Yao1, Shuang Zhao1, Kai Chen1, Qingrong Ma1, Wei Liang1, Guibin Qiao2* and Haiping Xiao1*  \nAbstract  \nBackground Primary giant mediastinal neoplasms are extremely uncommon. Large-sample studies are rare yet urgently needed.  \nMethods We conducted a retrospective analysis of consecutive cases who underwent excision surgery for giant mediastinal neoplasms between January 2019 and December 2023. Demographic, surgical, and prognosis data were retrospective collected and analyzed.  \nResults Thirty-two cases were analyzed. The most prevalent location was prevascular compartment (21 cases, 65. 6%), followed by visceral compartment (9 cases, 28 . 1%), and paravertebral compartment (2 cases, 6 . 3%) . Eighteen cases underwent preoperative biopsy, of which 15 consistent with postoperative outcomes. Seven cases underwent preoperative embolization. Median thoracotomy was the most common surgical approach (23 cases, 71 . 9%) . The median operation time was 214 min (interquartile range, IQR: 149–252), with a median blood loss of 500 ml (IQR:  \n200–800) . Thymic tumors were the most prevalent (13 cases, 40 . 6%), followed by mesenchymal (9 cases, 28 . 1%), germ-cell (5 cases, 15. 6%), pulmonary malignant neoplasms (2 cases, 6 . 2%), and other rare types (3 cases, 9 .4%) . The pathological classification demonstrated a significant association with prognosis (p = 0 . 006), with pulmonary malignancies exhibiting the worst outcomes. No significant overall survival difference was observed in malignant tumor patients with versus without local organ invasion (p = 0 . 896) . R2 resection correlated with significantly poorer survival compared to R0 (p = 0 . 001) .  \nConclusions With varied pathological types and complex surgical procedures, giant mediastinal tumors demand multidisciplinary treatment in experienced centers. Complete surgical resection is key to a good prognosis. Keywords Giant mediastinal tumors, Preoperative embolization, Surgery, Multidisciplinary treatment  \n†Qihang Zhu and Zhe He contributed equally to this work.  \n*Correspondence: Guibin Qiao [guibinqiao@126.com](guibinqiao@126.com)[ ](guibinqiao@126.com)Haiping Xiao [xhp2023xhp@126.com](xhp2023xhp@126.com)  \n1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China 2Department of Thoracic Surgery, The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China  \n3Department of Thoracic surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this li","cbCaiizr6tP6qH0B","https://ap.wps.com/l/cbCaiizr6tP6qH0B","pdf",2189306,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What patient period and design were used to evaluate surgical management?\",\"answer\":\"A retrospective single-center analysis reviewed consecutive excision surgeries for giant mediastinal neoplasms from January 2019 to December 2023, using collected demographic, surgical, and prognostic data.\"},{\"question\":\"Which mediastinal compartments were most common among the 32 primary giant neoplasms?\",\"answer\":\"The prevascular compartment was most prevalent (21 cases), followed by the visceral compartment (9 cases) and the paravertebral compartment (2 cases).\"},{\"question\":\"What surgical or pathological factors were associated with prognosis?\",\"answer\":\"Pathological classification showed a significant association with prognosis, and R2 resection correlated with significantly poorer survival compared with R0.\"}]","Surgical management of 32 primary giant mediastinal neoplasms - a retrospective single-center analysis | PDF",1790109334,28]