[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-413455-105":59,"doc-detail-413455-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","suprasellar-arachnoid-cyst-revealed-by-central-diabetes-insipidus-image-in-medicine","Suprasellar arachnoid cyst revealed by central diabetes insipidus - Image in medicine","","Case report of a 29-year-old man presenting with severe polyuria and polydipsia (~25 litres/day), sleep disruption, persistent fatigue, and chronic headaches. Laboratory findings showed hypernatremia and elevated plasma osmolality with low urine osmolality, confirming diabetes insipidus without anterior pituitary hormone deficiency. A desmopressin test supported central diabetes insipidus. Hypothalamic-pituitary MRI demonstrated a suprasellar arachnoid cyst and absence of the posterior pituitary bright spot, with preserved anterior pituitary. Conservative desmopressin replacement led to management success, emphasizing timely recognition and MRI-guided care without the poorly tolerated fluid deprivation test.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/suprasellar-arachnoid-cyst-revealed-by-central-diabetes-insipidus-image-in-medicine/413455/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/suprasellar-arachnoid-cyst-revealed-by-central-diabetes-insipidus-image-in-medicine/413455.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What symptoms and laboratory results supported the diagnosis in this case?","Question",{"text":112,"@type":113},"The patient had severe polyuria and polydipsia with sleep impairment, persistent fatigue, and chronic headaches. Hypernatremia with elevated plasma osmolality contrasted with low urine osmolality, confirming diabetes insipidus without anterior pituitary hormone deficiency.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the desmopressin test contribute to the diagnosis?",{"text":117,"@type":113},"The desmopressin administration test confirmed central diabetes insipidus by demonstrating a total response to desmopressin.",{"name":119,"@type":110,"acceptedAnswer":120},"What did MRI show regarding the arachnoid cyst and pituitary findings?",{"text":121,"@type":113},"Hypothalamic-pituitary MRI revealed a suprasellar arachnoid cyst with absence of the posterior pituitary bright spot, while the anterior pituitary gland appeared preserved.",{"name":123,"@type":110,"acceptedAnswer":124},"Why was conservative treatment chosen and what was the clinical takeaway?",{"text":125,"@type":113},"Treatment used conservative desmopressin replacement without surgery. The report highlights that prompt recognition using hypothalamic-pituitary MRI supports restoring fluid balance and improving symptoms, avoiding the poorly tolerated fluid deprivation test.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},413455,1790863324,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":24,"preview_page_count":4},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Images in clinical medicine   \nSuprasellar arachnoid cyst revealed by central diabetes insipidus  \nYoussra Lammini, Faycal El Guendouz  \nCorresponding author: Faycal El Guendouz, Department of Endocrinology and Metabolism, Moulay Ismail Military Hospital, Meknes Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohammed Ben Abdellah University, Fez, Morocco. [el.guendouz@gmail.com](el.guendouz@gmail.com)  \nReceived: 15 Sep 2025-Accepted: 05 Oct 2025-Published: 14 Oct 2025  \nKeywords: Central diabetes insipidus, arachnoid cyst, hypothalamic-pituitary MRI  \nFunding: This work received no specific grant from any funding agency in the public, commercial, or non-profit sectors.  \nCopyright: Youssra Lammini et al. Pan African Medical Journal (ISSN: 1937-8688) . This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License ( [https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nCite this article: Youssra Lammini et al. Suprasellar arachnoid cyst revealed by central diabetes insipidus. Pan African Medical Journal. 2025;52(71) . 10. 11604/pamj.2025.52.71.49392  \nAvailable online at: [https://www.panafrican-med-journal.com//content/article/52/71/full](https://www.panafrican-med-journal.com//content/article/52/71/full)  \nSuprasellar arachnoid cyst revealed by central diabetes insipidus  \nYoussra Lammini1, Faycal El Guendouz1,&  \nMeknes Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohammed Ben Abdellah University, Fez, Morocco  \n1 Department of Endocrinology and Metabolism, Moulay Ismail Military Hospital, Meknes Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohammed Ben Abdellah University, Fez, Morocco  \n&Corresponding author  \nFaycal EL Guendouz, Department of Endocrinology and Metabolism, Moulay Ismail Military Hospital,  \nImage in medicine  \nWe report the case of a 29-year-old man with severe polyuria and polydipsia (~25 litres per day) affecting the quality of the patient's sleep, persistent fatigue, and chronic headaches. Laboratory evaluation revealed hypernatremia (145 mmol/L), elevated plasma osmolality (298 .65 mOsm/kg), which contrasts with low urine osmolality (121 mOsm/kg), confirming diabetes insipidus without deficient secretion of anterior pituitary hormones. The desmopressin administration test confirmed the diagnosis of central diabetes insipidus, showing a total response to desmopressin. Magnetic resonance imaging of the hypothalamic-pituitary region revealed an  \narachnoid cyst with the absence of the posterior pituitary bright spot (Panel A), while the anterior pituitary gland appeared preserved (Panel B) . Treatment was conservative with simple desmopressin replacement therapy without surgery. This case illustrates the rare association between an arachnoid cyst and central diabetes insipidus, probably due to chronic hypothalamic compression rather than traction of the pituitary stalk. Prompt recognition and management are crucial for restoring fluid balance, improving sleep, reducing fatigue, and minimising the psychosocial impact. This report highlights the clinical importance of hypothalamic-pituitary MRI in the management of central diabetes insipidus without resorting to the fluid deprivation test, which is poorly tolerated by patients.  \nFigure 1: T1-weighted MRI of the hypothalamic-pituitary region (A) coronal; B) suprasellar arachnoid cyst with downward herniation of the suprasellar cistern; the posterior pituitary bright spot is absent, while the anterior pituitary gland is preserved","cbCaivXhlxDx43rL","https://ap.wps.com/l/cbCaivXhlxDx43rL","pdf",762918,"English","# Case presentation and diagnosis\n## Laboratory findings and desmopressin response\n## MRI findings and interpretation\n# Management and clinical implications","[{\"question\":\"What symptoms and laboratory results supported the diagnosis in this case?\",\"answer\":\"The patient had severe polyuria and polydipsia with sleep impairment, persistent fatigue, and chronic headaches. Hypernatremia with elevated plasma osmolality contrasted with low urine osmolality, confirming diabetes insipidus without anterior pituitary hormone deficiency.\"},{\"question\":\"How did the desmopressin test contribute to the diagnosis?\",\"answer\":\"The desmopressin administration test confirmed central diabetes insipidus by demonstrating a total response to desmopressin.\"},{\"question\":\"What did MRI show regarding the arachnoid cyst and pituitary findings?\",\"answer\":\"Hypothalamic-pituitary MRI revealed a suprasellar arachnoid cyst with absence of the posterior pituitary bright spot, while the anterior pituitary gland appeared preserved.\"},{\"question\":\"Why was conservative treatment chosen and what was the clinical takeaway?\",\"answer\":\"Treatment used conservative desmopressin replacement without surgery. The report highlights that prompt recognition using hypothalamic-pituitary MRI supports restoring fluid balance and improving symptoms, avoiding the poorly tolerated fluid deprivation test.\"}]","Suprasellar arachnoid cyst revealed by central diabetes insipidus - Image in medicine | PDF",1790594907]