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Neurol. 2025; 80(12): 44338 [https://doi.org/10.31083/RN44338](https://doi.org/10.31083/RN44338)  \nOriginal Article  \nSuperior Outcomes With Ommaya Reservoir in Sustained Intracranial Hypertension Control  \nYuying Cen 1, Yuheng Shan2, Xiaojiao Xu3, Jiahua Zhao4, Jiatang Zhang4 , *  \n1 Center of Neurology, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China  \n2Department of Neurology, Characteristic Medical Center of Chinese People’s Armed Police Force, 300162 Tianjin, China  \n3 School of Medicine, Nankai University, 300191 Tianjin, China  \n4Department of Neurology, The First Medical Centre, Chinese People’s Liberation Army (PLA) General Hospital, 100853 Beijing, China  \n*Correspondence: [zjt1128@aliyun.com](zjt1128@aliyun.com); [18843106944@163.com](18843106944@163.com) (Jiatang Zhang) Academic Editor: Jaume Sastre-Garriga  \nSubmitted: 27 June 2025 Revised: 25 September 2025 Accepted: 17 October 2025 Published: 25 December 2025  \nAbstract  \nBackground: Persistent intracranial hypertension (ICH) is a difficulty that must frequently be faced in the neuro-intensive care unit (ICU) . The management of ICH is quite varied, and the choice of measures is determined by the experience of attending doctors. We aimed to evaluate the efficacy of different intervention measures in treating non-traumatic persistent ICH. Methods: A total of 119 non-traumatic intracranial hypertension cases treated in the neuro-ICU of the PLA General Hospital between 2010 and 2023 were retrospectively reviewed. Patients were divided into five groups according to the methods for controlling intracranial pressure (ICP) . Based on the records of ICP, biochemical indicators, general status, and prognosis of patients in each group, the differences between groups and the differences within groups before and after intervention were compared. Repeated measures data of multiple groups were analyzed using generalized estimating equation (GEE) methods. Results: External ventricular drain (EVD), lumbar drainage (LD) and Ommaya reservoir (OR) had advantages in reducing ICP compared with the drug therapy alone (DT) group. Among them, the Ommaya reservoir exhibited optimal efficacy. Intervention with repeated lumbar puncture (LP) and the Ommaya reservoir effectively improved the general state of patients, evidenced by decreased mRS scores. The median creatinine value in the OR group decreased significantly at three months, suggesting that this method can moderate the renal burden. The OR group had the lowest probability of electrolyte imbalancesand renal function damage, while the LD and EVD groups had a higher probability of pulmonary infection. Conclusions: The Ommaya reservoir is an effective and safe means of controlling ICP and thus has great potential in treating non-traumatic persistent ICH.  \nKeywords: intracranial hypertension; Ommaya reservoir; external ventricular drain; lumbar drainage; acute kidney injury  \nResultados Superiores con el Reservorio de Ommaya en el Control Continuo de la Hipertensión Intracraneal  \nResumen  \nAntecedentes: La hipertensión intracraneal persistente (ICH, persistent intracranial hypertension) es una dificultad a la que hay que enfrentarse con frecuencia en la UCI neurológica. El tratamiento de la ICH es muy variado y la elección de las medidas dependerá de la experiencia de los médicos responsables. Nuestro objetivo fue evaluar la eficacia de diferentesmedidas de intervención a la hora de tratar la ICH persistente no traumática. Métodos: Se revisaron retrospectivamente un total de 119 casos de hipertensión intracraneal no traumática tratados en la UCI neurológica del Hospital General del Ejército Popular de Liberación (PLA General Hospital) entre los años 2010 y 2023 . Se dividió a los pacientes en cinco grupos, según los métodos utilizados para controlar la presión intracraneal (PIC) . A partir de los registros de PIC, los indicadores bioquímicos, el estado general y el pronóstico de los pacientes de cada ","cbCaitmdrhV397XJ","https://ap.wps.com/l/cbCaitmdrhV397XJ","pdf",1842350,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the study’s purpose in treating non-traumatic persistent intracranial hypertension?\",\"answer\":\"To evaluate the efficacy of different intervention measures for treating non-traumatic persistent intracranial hypertension by comparing outcomes across five ICP-control methods.\"},{\"question\":\"How were patients grouped and what data were compared?\",\"answer\":\"A total of 119 non-traumatic ICH cases were divided into five groups based on the ICP-control methods used, and group differences were assessed using ICP records, biochemical indicators, general status, and prognosis.\"},{\"question\":\"What did the results show about the Ommaya reservoir compared with other interventions?\",\"answer\":\"External ventricular drain, lumbar drainage, and the Ommaya reservoir reduced ICP compared with drug therapy alone, and the Ommaya reservoir demonstrated optimal efficacy, improved general state via lower mRS scores, and showed the lowest probability of electrolyte imbalance and renal function damage.\"}]","Superior Outcomes With Ommaya Reservoir in Sustained Intracranial Hypertension Control | PDF",1790753581]