[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-442756-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-442756-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","successful-treatment-of-a-patient-with-neuropsychiatric-lupus-and-triple-positive-antiphospholipid-syndrome-case-report","Successful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome - Case Report","","Neuropsychiatric systemic lupus erythematosus (NPSLE) refers to neurologic and psychiatric syndromes in patients with SLE after other causes are excluded. Diagnosis remains difficult because diverse clinical presentations lack specific laboratory or radiologic biomarkers. The case report describes a patient with SLE and chronic isolated seizure successfully treated with antiepileptic medication and high-dose corticosteroids, with consideration of ischemic and inflammatory seizure mechanisms alongside lupus activity.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/successful-treatment-of-a-patient-with-neuropsychiatric-lupus-and-triple-positive-antiphospholipid-syndrome-case-report/442756/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/successful-treatment-of-a-patient-with-neuropsychiatric-lupus-and-triple-positive-antiphospholipid-syndrome-case-report/442756.png","ImageObject",300,407,{"name":42,"@type":43},"PakDamar76","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is neuropsychiatric lupus (NPSLE) in systemic lupus erythematosus (SLE)?","Question",{"text":63,"@type":64},"NPSLE includes neurologic and psychiatric syndromes seen in SLE patients after excluding other causes. Diagnosis is challenging due to varied clinical manifestations and limited biomarker availability.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the patient’s seizure characterized in the case?",{"text":68,"@type":64},"The patient had intermittent seizures lasting 10–15 seconds with blank stares and tonic flexion of the upper extremities, progressing to near-weekly episodes lasting 1–2 minutes with postictal confusion.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment led to successful seizure control in this case?",{"text":72,"@type":64},"Seizures were controlled with antiepileptic therapy (levetiracetam) and high-dose glucocorticoids, alongside ongoing lupus-directed medications including hydroxychloroquine and azathioprine.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},442756,1790777987,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":123,"preview_page_count":4},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","CASE REPORT  \nSuccessful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome with Chronic Isolated Seizure: A Case Report  \nMark Andrian O. Yano, MD and Evelyn O. Salido, MD, MSc  \nDivision of Rheumatology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila  \nABSTRACT  \nNeuropsychiatric SLE (NPSLE) comprises the neurologic and psychiatric syndromes observed in patients with SLE after exclusion of other causes. The diagnosis of NPSLE is challenging due to diverse clinical manifestations and absence of laboratory or radiologic biomarkers.  \nWe present the case of a patient with SLE with a chronic isolated seizure and was successfully managed with antiepileptic medication and high-dose corticosteroids.  \nSeizures may occur as an isolated manifestation of an SLE flare. Ischemic and inflammatory causes of seizure may coexist in active lupus and both should be considered in managing patients. A prompt and holistic workup to rule out metabolic, infectious, and structural neural causes and lupus disease activity of seizures is prudent for patients with SLE.  \nKeywords: neuropsychiatric lupus, antiphospholipid syndrome, SLE, seizure, case report  \nINTRODUCTION  \nPoster presentation – Philippine Rheumatology Association 29th Annual Meeting, February 1-4, 2023, Newtown Plaza Events Center, Baguio City, Philippines.  \neISSN 2094-9278 (Online) Published: November 28, 2025  \n[https://doi.org/10.47895/amp.vi0.11710](https://doi.org/10.47895/amp.vi0.11710)  \n[Copyright: The Author](Copyright: The Author)([s](s)) 2025  \nCorresponding author: Mark Andrian O. Yano, MD  \nDivision of Rheumatology Department of Medicine Philippine General Hospital University of the Philippines Manila  \nTaft Avenue, Ermita, Manila 1000, Philippines [Email: markyano91@gmail.com](Email: markyano91@gmail.com)  \nSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with a variety of clinical manifestations. Neuropsychiatric SLE (NPSLE) comprises the neurologic and psychiatric syndromes observed in patients with SLE after exclusion of other causes.1 The diagnosis of NPSLEis challenging due to diverse clinical manifestations and absence of laboratory or radiologic biomarkers.2  \nCASe PReSeNTATION  \nWereport the case ofa 21-year-old female diagnosed with SLE in 2015, seven years prior to hospitalization. Her initial lupus manifestations were malar rash, polyarthralgia, anemia, and positive serologies (anti-nuclear antibody and anti-double stranded DNA). She was maintained on low-dose prednisone and hydroxychloroquine. In 2019, she had SLE nephritis and was treated with methylprednisolone pulse therapy for three days, monthly cyclophosphamide infusion for six months and 4 quarterly doses. Azathioprine 75 mg daily was added to low-dose prednisone and hydroxychloroquine 200 mg daily. These were taken with good compliance and she remained free of lupus flares. She has no comorbidities. She is a student  \nSuccessful Treatment of a Patient with NPSLE and APAS  \nwith no history of substance use or psychiatric illness and no family history of autoimmune or seizure disorder.  \nDuring her hospitalization on July 2022, she was referred to the rheumatology service because of intermittent seizures of three months duration. Episodes were characterized as blank stares with tonic flexion of the upper extremities lasting for 10-15 seconds, pooling of saliva, and postictal confusion for 10 seconds. The episodes were initially once to twice a month but gradually increased in frequency and duration to almost weekly and lasting for 1 to 2 minutes. She dismissed the early seizure episodes as stress-related due to her studies but grew alarmed when they became more frequent and prolonged. She admitted to being fearful of what the seizures meant for her health, especially since she had previously enjoyed stable disease control. She had no other symptoms of an SLE flare like rash, alopecia, oral ulcers","cbCaime2ovIbhkal","https://ap.wps.com/l/cbCaime2ovIbhkal","pdf",202799,"English","# Abstract\n# Introduction\n# Case Presentation\n## Seizure history and clinical course\n## Physical examination and laboratory findings\n## Imaging and cerebrospinal fluid results\n## Treatment and outcome","[{\"question\":\"What is neuropsychiatric lupus (NPSLE) in systemic lupus erythematosus (SLE)?\",\"answer\":\"NPSLE includes neurologic and psychiatric syndromes seen in SLE patients after excluding other causes. Diagnosis is challenging due to varied clinical manifestations and limited biomarker availability.\"},{\"question\":\"How was the patient’s seizure characterized in the case?\",\"answer\":\"The patient had intermittent seizures lasting 10–15 seconds with blank stares and tonic flexion of the upper extremities, progressing to near-weekly episodes lasting 1–2 minutes with postictal confusion.\"},{\"question\":\"What treatment led to successful seizure control in this case?\",\"answer\":\"Seizures were controlled with antiepileptic therapy (levetiracetam) and high-dose glucocorticoids, alongside ongoing lupus-directed medications including hydroxychloroquine and azathioprine.\"}]","Successful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome - Case Report | PDF",1790701536]