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Yet around one quarter of patients present with disease deemed unresectable. This case describes a 42-year-old man with ascending colon adenocarcinoma and liver metastases initially judged unresectable due to tumor size and right portal vein compression. Multidisciplinary downstaging used preoperative TACE, surgery, neoadjuvant chemotherapy, additional TACE after recurrence, and γ-knife, achieving pathologically complete response and >9-year overall survival.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/successful-multidisciplinary-therapy-for-a-patient-with-liver-metastasis-from-ascending-colon-adenocarcinoma-a-case-report-and-review-of-literature/378705/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/successful-multidisciplinary-therapy-for-a-patient-with-liver-metastasis-from-ascending-colon-adenocarcinoma-a-case-report-and-review-of-literature/378705.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why were the liver metastases initially considered unresectable?","Question",{"text":113,"@type":114},"They were initially judged unresectable because of the huge lesion size and compression of the right portal vein.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which multidisciplinary treatments were used in this case?",{"text":118,"@type":114},"The patient received preoperative transcatheter arterial chemoembolization (TACE), radical colectomy with anastomosis, neoadjuvant chemotherapy followed by partial hepatectomy, additional TACE after intrahepatic recurrence, and γ-knife for local control.",{"name":120,"@type":111,"acceptedAnswer":121},"What outcome did the therapy achieve?",{"text":122,"@type":114},"A pathologically complete response (pCR) was reached, and the patient’s overall survival time exceeded 9 years.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378705,1790379164,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 March 6; 11(7): 1498-1505  \nDOI: 10.12998/wjcc.v11.i7.1498 ISSN 2307-8960 (online)  \nCASE REPORT  \nSuccessful multidisciplinary therapy for a patient with liver metastasis from ascending colon adenocarcinoma: A case report and review of literature  \nXiao-Rong Tan, Juan Li, Hua-Wei Chen, Wei Luo, Nan Jiang, Zheng-Bo Wang, Shuai Wang  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): A  \nGrade B (Very good): 0  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): E  \nP-Reviewer: Osera S, Japan; Surlin VM, Romania; Teragawa H, Japan  \nReceived: September 20, 2022  \nPeer-review started: September 20, 2022  \nFirst decision: December 26, 2022  \nRevised: January 7, 2023  \nAccepted: February 10, 2023  \nArticle in press: February 10, 2023  \nPublished online: March 6, 2023  \nXiao-Rong Tan, Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China  \nJuan Li, Hua-Wei Chen, Wei Luo, Nan Jiang, Zheng-Bo Wang, Shuai Wang, Department of Oncology, Daping Hospital, Army Medical University, Chongqing 400042, China  \nCorresponding author: Shuai Wang, MS, Associate Chief Physician, Department of Oncology, Daping Hospital, Army Medical University, No. 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, [China.](China. sharondenise_mine@163.com)[ sharondenise_mine@163.com](China. sharondenise_mine@163.com)  \nAbstract  \nBACKGROUND  \nLiver metastasis is the most common form of distant metastasis in colorectal cancer, and the only possible curative treatment for patients with colorectal liver metastases (CRLM) is hepatectomy. However, approximately 25% of patients with CRLM have indications for liver resection at the initial diagnosis. Strategies aimed at downstaging large or multifocal tumors to enable curative resection are appealing.  \nCASE SUMMARY  \nA 42-year-old man was diagnosed with ascending colon cancer and liver metastases. Due to the huge lesion size and compression of the right portal vein, the liver metastases were initially diagnosed as unresectable lesions. The patient was treated with preoperative transcatheter arterial chemoembolization (TACE) consisting of 5-fluorouracil/Leucovorin/oxaliplatin/Endostar® . After four courses, radical right-sided colectomy and ileum transverse colon anastomosis were performed. Postoperatively, the pathological analysis revealed moderately differentiated adenocarcinoma with necrosis and negative margins. Thereafter, S7/S8 partial hepatectomy was performed after two courses of neoadjuvant chemotherapy. Pathological examination of the resected specimen revealed a pathologically complete response (pCR) . Intrahepatic recurrence was detected more than two months after the operation, and the patient was then treated with TACE consisting of irinotecan/Leucovorin/fluorouracil therapy plus Endostar® . Subsequently, the patient was treated with a γ-knife to enhance local control. Notably, a pCR was reached, and the patient's overall survival time was > 9 years.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 1498 March 6, 2023  Volume 11  Issue 7   \nTan XR et al. Successful multidisciplinary therapy in colorectal cancer  \nCONCLUSION  \nMultidisciplinary treatment can promote the conversion of initially unresectable colorectal liver metastasis and facilitate complete pathological remission of liver lesions.  \nKey Words: Initially unresectable colorectal liver metastasis; Conversion chemotherapy; Multidisciplinary therapy; Pathological complete response; Transca","cbCaidQlgDHilqoC","https://ap.wps.com/l/cbCaidQlgDHilqoC","pdf",3662494,"English","# Abstract\n## Background\n## Case Summary\n## Conclusion\n# Introduction","[{\"question\":\"Why were the liver metastases initially considered unresectable?\",\"answer\":\"They were initially judged unresectable because of the huge lesion size and compression of the right portal vein.\"},{\"question\":\"Which multidisciplinary treatments were used in this case?\",\"answer\":\"The patient received preoperative transcatheter arterial chemoembolization (TACE), radical colectomy with anastomosis, neoadjuvant chemotherapy followed by partial hepatectomy, additional TACE after intrahepatic recurrence, and γ-knife for local control.\"},{\"question\":\"What outcome did the therapy achieve?\",\"answer\":\"A pathologically complete response (pCR) was reached, and the patient’s overall survival time exceeded 9 years.\"}]","Successful multidisciplinary therapy for a patient with liver metastasis from ascending colon adenocarcinoma - A case report and review of literature | PDF",1790232023,23]