[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336760-105":59,"doc-detail-336760-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","subtle-presentation-of-two-rare-gynecological-cancers-in-a-single-patient-a-case-report","Subtle Presentation of Two Rare Gynecological Cancers in a Single Patient - A Case Report","","Yolk sac tumors (YSTs) are rare germ-cell malignancies, while gastric-type adenocarcinoma of the endocervix (GAS) is an uncommon cervical cancer with distinctive clinical and pathological behavior. This case report describes a 33-year-old woman with postcoital bleeding and atypical glandular proliferation diagnosed as GAS. Notably, she previously had a YST treated with left salpingo-oophorectomy and chemoradiation five years earlier. Follow-up ultrasound showed no residual disease. The report analyzes possible predisposing factors and asks whether a link exists to guide surveillance, therapy selection, and improved outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/subtle-presentation-of-two-rare-gynecological-cancers-in-a-single-patient-a-case-report/336760/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/subtle-presentation-of-two-rare-gynecological-cancers-in-a-single-patient-a-case-report/336760.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What rare malignancies are described in this single-patient case report?","Question",{"text":112,"@type":113},"The report involves a prior yolk sac tumor (YST) and a later diagnosis of gastric-type adenocarcinoma of the endocervix (GAS). Both occur in the same patient, creating a challenging clinical context.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What symptoms and initial findings led to the later diagnosis?",{"text":117,"@type":113},"The patient presented with postcoital bleeding and a sizeable vaginal mass with irregular contour. MRI revealed a cervical mass, and curettage showed atypical glandular fragments consistent with GAS.",{"name":119,"@type":110,"acceptedAnswer":120},"How did pathology and immunostaining support the diagnosis of GAS?",{"text":121,"@type":113},"Biopsies showed abundant mucin and nuclear atypia, with squamous atypia and increased Ki67 staining. The atypia was unusual because p16 staining was negative in both glandular and squamous components, and additional biopsies confirmed GAS.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336760,1790119175,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review began 08/05/2024  \nReview ended 08/13/2024  \nPublished 08/19/2024  \n© Copyright 2024  \nEstevez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.67239  \nOpen Access Case Report  \nSubtle Presentation of Two Rare Gynecological Cancers in a Single Patient: A Case Report  \nEden Estevez 1 , Frederick Friedman 2, Tiangui Huang 3, Nora Morgenstern 3  \n1. Obstetrics and Gynecology, St. George’s University School of Medicine, St. George, GRD 2. Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Queens, USA 3. Pathology, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Queens, USA  \nCorresponding author: Eden Estevez, [eestevez@sgu.edu](eestevez@sgu.edu)  \nAbstract  \nYolk sac tumors (YSTs) are rare germ-cell malignancies that usually develop in the gonads. Similarly, gastric-type adenocarcinoma of the endocervix (GAS) is a rare kind of gynecological cancer that has piqued interest due to its distinctive clinical and pathological features. These two malignancies in a single patient present a unique and challenging scenario. Here, we present the case of a 33-year-old female who presented with postcoital bleeding and was diagnosed with atypical glandular proliferation consistent with GAS. Interestingly, this patient had a history of a YST treated with left salpingo-oophorectomy and chemoradiation in the Philippines five years prior. A follow-up ultrasound report in the Philippines five months after treatment showed no evidence of residual disease. This case report aims to understand the predisposing factors of these neoplasms and asks if there is a link between them, which is necessary for tailoring surveillance, appropriate therapeutic approaches, and improving patient outcomes.  \nCategories: Pathology, Obstetrics/Gynecology, Oncology  \nKeywords: yolk sac tumor, human papillomavirus-independent cervical cancer, atypical glandular proliferation, gastric-type endocervical adenocarcinoma, cervical cancer, endocervical adenocarcinoma, gastric-type adenocarcinoma  \nIntroduction  \nYolk sac tumors (YSTs) are usually diagnosed in children and young adults under 40 [1] . These germ-cell tumors rapidly grow and tend to metastasize to lymph nodes early [1] . Treatment usually involves surgical removal and chemotherapy. Endocervical adenocarcinoma (ECA) is an uncommon type of cervical cancer that develops from the cervix 's glandular cells and accounts for 20-25% of all cervical cancers [2] . We classify ECA into two main types based on histopathological features and etiological factors: human papillomavirus (HPV)-associated usual type and HPV-independent gastric type [3] . The literature has not extensively documented the uncommon occurrence of a YST and gastric-type adenocarcinoma of the cervix (GAS) in the same patient. This case report discusses the clinical presentation, diagnostic problems, and potential treatments for managing a patient with an unusual oncological history. We describe the case of a 33-yearold female with a prior history of YSTs, diagnosed and treated at the age of 28, who experienced postcoital bleeding and was diagnosed with HPV-negative glandular atypia. This report details a specific patient case to understand better the potential complexities and relationships between these rare and distinct malignancies.  \nCase Presentation  \nHerein, we have a 33-year-old G 1P 1001 female with a past medical history of a YST, status post left laparoscopic salpingo-oophorectomy and chemoradiation at age 28, who presented with postcoital bleeding and a sizeable vaginal mass with irregular contour on speculum examination. Magnetic resonance imaging (MRI) revealed a cervical mass. The patient has a family history of vaginal cancer, leukemia, and lung","cbCainqZP9h0URUn","https://ap.wps.com/l/cbCainqZP9h0URUn","pdf",3941585,"English","# Abstract\n# Introduction\n# Case Presentation\n## Clinical history and symptoms\n## Physical and imaging findings\n## Pathology and immunostaining results\n# How to cite this article\n# Figures","[{\"question\":\"What rare malignancies are described in this single-patient case report?\",\"answer\":\"The report involves a prior yolk sac tumor (YST) and a later diagnosis of gastric-type adenocarcinoma of the endocervix (GAS). Both occur in the same patient, creating a challenging clinical context.\"},{\"question\":\"What symptoms and initial findings led to the later diagnosis?\",\"answer\":\"The patient presented with postcoital bleeding and a sizeable vaginal mass with irregular contour. MRI revealed a cervical mass, and curettage showed atypical glandular fragments consistent with GAS.\"},{\"question\":\"How did pathology and immunostaining support the diagnosis of GAS?\",\"answer\":\"Biopsies showed abundant mucin and nuclear atypia, with squamous atypia and increased Ki67 staining. The atypia was unusual because p16 staining was negative in both glandular and squamous components, and additional biopsies confirmed GAS.\"}]","Subtle Presentation of Two Rare Gynecological Cancers in a Single Patient - A Case Report | PDF",1790016480,13]