[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353701-105":59,"doc-detail-353701-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","submucosal-laryngeal-lesions-a-puzzling-diagnostic-conundrum","Submucosal laryngeal lesions - A puzzling diagnostic conundrum","","Laryngeal mucosal masses are often squamous cell carcinomas and are typically identifiable and biopsied endoscopically, whereas submucosal laryngeal masses present a broad differential covering benign and malignant epithelial and non-epithelial neoplasms plus non-neoplastic entities such as vascular malformations, infectious or inflammatory disease, submucosal hematoma, amyloidosis and laryngoceles. Because mucosa may appear intact, biopsy can be challenging with higher false-negative or inadequate sampling. Imaging features may narrow the differential and guide workup and management.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/submucosal-laryngeal-lesions-a-puzzling-diagnostic-conundrum/353701/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/submucosal-laryngeal-lesions-a-puzzling-diagnostic-conundrum/353701.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are submucosal laryngeal lesions harder to diagnose than mucosal masses?","Question",{"text":113,"@type":114},"They often lack visible mucosal abnormality on endoscopy, so biopsy may be difficult and is associated with higher rates of false negatives or inadequate sampling.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What conditions are included in the differential diagnosis of submucosal laryngeal masses?",{"text":118,"@type":114},"The differential includes benign and malignant epithelial and non-epithelial neoplasms, as well as non-neoplastic abnormalities such as vascular malformations, infectious or inflammatory pathologies, submucosal hematoma, amyloidosis, and laryngoceles.",{"name":120,"@type":111,"acceptedAnswer":121},"How can radiologic imaging help in managing these lesions?",{"text":122,"@type":114},"Although imaging features can be nonspecific, certain lesions may show typical imaging patterns that help narrow the differential and direct diagnostic workup and clinical management more effectively.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},353701,1790146217,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","European Journal of Radiology Open 16 (2026) 100735  \nContents lists available at ScienceDirect  \nEuropean Journal of Radiology Open  \njournal [homepage:](homepage: www.elsevier.com/locate/ejro)[ www.elsevier.com/locate/ejro](homepage: www.elsevier.com/locate/ejro)  \nReview  \nSubmucosal laryngeal lesions: A puzzling diagnostic conundrum☆ Melissa Shuhui Lee a,*, Jean Lee b,c, Richard Wigginsd  \na Department of Neuroradiology, Singapore General Hospital/National Neuroscience Institute, Block 2, Level 1, Singapore General Hospital, Outram Rd, 169608, Singapore  \nb Medical Imaging Department, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia c University of Melbourne, Parkville, VIC 3010, Australia  \nd Department of Radiology & Imaging Sciences, University of Utah Health, 30 North, 1900 East \\#1A071, Salt Lake City, UT 84132-2140, USA  \nH I G H L I G H T S  \n\n| • Submucosal laryngeal lesions have a broad differential diagnosis and lack visible mucosal abnormality, making biopsy of these lesions challenging.\u003Cbr>• This review article highlights imaging features which may aid distinction of one pathology from another.\u003Cbr>• A succinct summary of management options for each pathology are also discussed. |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: Submucosal Laryngeal\u003Cbr>Larynx Lesion\u003Cbr>Computed Tomography Magnetic Resonance Imaging |  | Laryngeal mucosal masses are commonly squamous cell carcinomas, easily identified and biopsied on scope. In contrast, a submucosal laryngeal mass has a broad differential diagnosis, including benign and malignant epithelial and non-epithelial neoplasms as well as other non-neoplastic abnormalities including vascular malformations, infective or inflammatory pathologies, submucosal hematoma, rare depositional diseases such as amyloidosis, and other benign lesions such as laryngoceles. Due to a lack of visible mucosal abnormality, biopsy of these lesions are often challenging with higher rates of false negatives or inadequate sampling. Whilst radiological imaging features of submucosal laryngeal lesions may be non-specific, there are some lesions which may exhibit typical imaging features which could help radiologists to narrow the differential diagnosis and direct diagnostic workup and clinical management more effectively. In this article, we will illustrate a spectrum of submucosal laryngeal lesions, with an emphasis on helpful imaging features to help distinguish pathologies, and an overview of appropriate workup and management aspects which the radiologist needs to know to contribute effectively to patient care. |\n\n1. Introduction  \nWhilst laryngeal mucosal masses are commonly squamous cell carcinomas(SCC), easily identified and biopsied on scope, a submucosal laryngeal mass may be elusive and has a broad differential diagnosis. These include benign and malignant epithelial and non-epithelial neoplasms as well as other non-neoplastic abnormalities including vascular malformations, infective or inflammatory pathologies, submucosal hematoma, rare depositional diseases, and other benign lesions such aslaryngoceles.  \nThe submucosa of the true vocal cords is made up of loose connective tissue containing loosely interwoven collagen and elastic fibers without lymphatics or salivary glands, known as the superficial lamina propria. This lies deep to the epithelium and superficial to the vocal ligament (intermediate and deep lamina propria), which lies next to the vocalis muscle. For the purposes of this review article, the term “submucosal laryngeal lesion” refers to a lesion which presents as an endoluminal surface bulge on endoscopy with intact overlying mucosa. These lesions may arise from submucosal structures (muscles, membranes, fat, cartilages, and/or deep spaces) or from the deeper mucosa. Due to a lack of  \nAbbreviations: ADC, Apparent diffusion coefficient; CT, Computed Tomography; DWI, Diffusion Weighted Imaging; MRI, Magnet","cbCaistZoCrTIjg8","https://ap.wps.com/l/cbCaistZoCrTIjg8","pdf",8048217,13,"English","# Review\n## Introduction\n## Imaging features and differential diagnosis\n## Workup and management options","[{\"question\":\"Why are submucosal laryngeal lesions harder to diagnose than mucosal masses?\",\"answer\":\"They often lack visible mucosal abnormality on endoscopy, so biopsy may be difficult and is associated with higher rates of false negatives or inadequate sampling.\"},{\"question\":\"What conditions are included in the differential diagnosis of submucosal laryngeal masses?\",\"answer\":\"The differential includes benign and malignant epithelial and non-epithelial neoplasms, as well as non-neoplastic abnormalities such as vascular malformations, infectious or inflammatory pathologies, submucosal hematoma, amyloidosis, and laryngoceles.\"},{\"question\":\"How can radiologic imaging help in managing these lesions?\",\"answer\":\"Although imaging features can be nonspecific, certain lesions may show typical imaging patterns that help narrow the differential and direct diagnostic workup and clinical management more effectively.\"}]","Submucosal laryngeal lesions - A puzzling diagnostic conundrum | PDF",1790106811,33]