[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-56167-en":3,"doc-seo-56167-105":29,"detail-sidebar-cat-0-en-105":90},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":13,"seo_description":14,"update_tm":27,"read_time":28},56167,549758146520,"Patrick","https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470",7,"Healthcare","Study on the Postprandial Blood Glucose Suppression Effect of D-Psicose in Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects","Clinical investigation evaluates the safety and glucose-lowering effect of D-psicose on postprandial blood glucose in adult men and women, including individuals with borderline diabetes. A randomized double-blind placebo-controlled crossover study assessed single 0 g or 5 g ingestion with a standard meal, measuring fasting and 30–120 min glucose; D-psicose significantly lowered glucose at 30 and 60 min and reduced the AUC. Long-term safety was tested in normal subjects over 12 weeks with 5 g D-psicose or D-glucose taken thrice daily, showing no abnormal effects or clinical problems.","Biosci. Biotechnol. Biochem., 74 (3), 510–519, 2010  \nStudy on the Postprandial Blood Glucose Suppression Effect of D-Psicosein Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects  \nNoriko HAYASHI, 1; y Tetsuo IIDA, 1 Takako YAMADA, 1 Kazuhiro OKUMA, 1 Isao TAKEHARA,2 Takashi YAMAMOTO,3 Koji YAMADA,4 and Masaaki TOKUDA5  \n1Research and Development, Matsutani Chemical Industry Co., Ltd., 5-3 Kita-Itami, Itami, Hyogo 664-8508, Japan  \n2New Drug Development Research Center, Inc., 452-1 Toiso, Eniwa, Hokkaido 061-1405, Japan  \n3AIEIsupport Ltd., 2-9 Ono, Itami, Hyogo 664-0003, Japan  \n4Rare Sugar Foods LLC, 307 Minatomachi, Marugame, Kagawa 763-0042, Japan  \n5Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan  \nReceived September 29, 2009; Accepted December 11, 2009; Online Publication, March 7, 2010 [doi:10.1271/bbb.90707]  \nThis clinical study was conducted to investigate the safety and effect of D-psicose on postprandial blood glucose levels in adult men and women, including borderline diabetes patients. A randomized doubleblind placebo-controlled crossover experiment of single ingestion was conducted on 26 subjects who consumed zero or 5 g of D-psicose in tea with a standard meal. The blood glucose levels at fasting and 30, 60, 90, and 120 min after the meal were compared. The blood glucose level was significantly lower 30 and 60 min after the meal with D-psicose (p \u003C 0:01, p \u003C 0:05), and asignificant decrease was also shown in the area under the curve (p \u003C 0:01). The results suggest that D-psicose had an effect to suppress the postprandial blood glucose elevation mainly in borderline diabetes cases. A randomized double-blind placebo-controlled parallelgroup experiment of long-term ingestion was conducted on 17 normal subjects who took 5 g of D-psicose or D-glucose with meals three times a day for 12 continuous weeks. Neither any abnormal effects nor clinical problems caused by the continuous ingestion of D-psicose were found.  \nKey words: D-psicose; sweetener; blood glucose; human; safety  \nPreventing and improving the metabolic syndromes associated with rapidly increasing dyslipidemia and hyperglycemia are urgent matters to resolve for reducing medical costs that have been rising in recent years. In particular, diabetes tends to accompany such complications as retinopathy, nephropathy and neuropathy; medical costs therefore increase, making it very important to reduce the disease. 1) Preventing and improving diabetes are based on correcting life-style habits.  \nAbove all, it is important to control blood glucose levels after a meal, and a number of studies are in progress to find dietary factors that can suppress blood glucose elevation by using the glycemic index.2–4)  \nD-Psicose (D-ribo-2-hexulose, CAS registration number 551-68-8, molecular formula C6H 12 O6 , molecular weight 180.156) is a C-3 epimer of D-fructose and is oneof the monosaccharides, a rare sugar, that are rarely found in nature. Matsuo et al. have clarified the glucose suppression effect of D-psicose by animal experiments. They showed an inhibition capability of 􀀁-glucosidasein the suppression mechanism and presumed that the compound had similar behavior to D-fructose in its glucose uptake from liver.5–7) Moreover, we have previously conducted a glucose loading experiment on healthy adults using a starch hydrolysate (glucose solution) as the carbohydrate source.8) The results showed that approximately 5 g of D-psicose to 75 g of carbohydrate significantly suppressed the blood glucose elevation. Approximately 1 part of D-psicose was effective to 15 parts of carbohydrate ingested. It was also confirmed that a single ingestion of D-psicose had no effect on the blood glucose and insulin levels, meaning that hypoglycemia would not be induced by D-psicose. Those studies showed that D-psicose had aneffect of suppressing the postprandial blood glucose elevation. However, from the","cbCaioRThKV2kFLA","https://ap.wps.com/l/cbCaioRThKV2kFLA","pdf",146174,1,10,"English","en",105,"# Background and rationale\n## Rationale for controlling postprandial glucose\n## D-Psicose characteristics and prior evidence\n# Study design and methods\n## Single-ingestion crossover trial\n## Long-term ingestion parallel trial\n# Results and findings\n## Postprandial glucose suppression\n## Long-term safety outcomes\n# Safety considerations and clinical implications","[{\"question\":\"What was the purpose of this clinical study?\",\"answer\":\"To evaluate the safety and effect of D-psicose on postprandial blood glucose levels in adults, including borderline diabetes patients.\"},{\"question\":\"How did the study test the effect of D-psicose after a meal?\",\"answer\":\"It used a randomized double-blind placebo-controlled crossover design where 26 subjects ingested either 0 g or 5 g D-psicose with a standard meal, and glucose was measured at fasting and 30, 60, 90, and 120 minutes.\"},{\"question\":\"What did the long-term ingestion trial show about safety?\",\"answer\":\"In 17 normal subjects taking 5 g D-psicose or D-glucose with meals three times daily for 12 weeks, no abnormal effects or clinical problems caused by continuous D-psicose ingestion were observed.\"}]",1783717333,25,{"code":4,"msg":30,"data":31},"ok",{"site_id":24,"language":23,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":27},"study-on-the-postprandial-blood-glucose-suppression-effect-of-d-psicose-in-borderline-diabetes-and-the-safety-of-long-term-ingestion-by-normal-human-subjects","",{"@graph":35,"@context":84},[36,53,67],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,47,50],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":46},"https://docshare.wps.com/document/","Document",2,{"item":48,"name":12,"@type":42,"position":49},"https://docshare.wps.com/document/healthcare/",3,{"item":51,"name":13,"@type":42,"position":52},"https://docshare.wps.com/document/study-on-the-postprandial-blood-glucose-suppression-effect-of-d-psicose-in-borderline-diabetes-and-the-safety-of-long-term-ingestion-by-normal-human-subjects/56167/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":23,"description":14,"dateModified":61,"datePublished":61,"encodingFormat":60,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":40,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-10",true,{"@type":64,"interactionType":65,"userInteractionCount":4},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"What was the purpose of this clinical study?","Question",{"text":74,"@type":75},"To evaluate the safety and effect of D-psicose on postprandial blood glucose levels in adults, including borderline diabetes patients.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"How did the study test the effect of D-psicose after a meal?",{"text":79,"@type":75},"It used a randomized double-blind placebo-controlled crossover design where 26 subjects ingested either 0 g or 5 g D-psicose with a standard meal, and glucose was measured at fasting and 30, 60, 90, and 120 minutes.",{"name":81,"@type":72,"acceptedAnswer":82},"What did the long-term ingestion trial show about safety?",{"text":83,"@type":75},"In 17 normal subjects taking 5 g D-psicose or D-glucose with meals three times daily for 12 weeks, no abnormal effects or clinical problems caused by continuous D-psicose ingestion were 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