[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-339414-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-339414-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","structure-inherent-tumor-targeted-ir-783-for-near-infrared-fluorescence-guided-photothermal-therapy","Structure-Inherent Tumor-Targeted IR-783 for Near-Infrared Fluorescence-Guided Photothermal Therapy","","IR-783 is a commercially available near-infrared (NIR) heptamethine cyanine dye used for selective tumor imaging in breast, prostate, cervical, and brain cancers. Despite limited mechanistic demonstration of its structure-inherent tumor targeting, IR-783 offers favorable water solubility and lower cytotoxicity than other commercial heptamethine cyanine dyes. This study evaluates IR-783 phototherapeutic performance as a tumor-targeted photothermal agent in human colorectal cancer xenografts. After intravenous dosing, IR-783 shows subcellular localization in HT-29 cells and preferential tumor accumulation at 24 h. Under 808 nm NIR laser irradiation, the dye efficiently converts light to heat in vitro and in vivo, inducing cancer cell death. Overall, water-soluble anionic IR-783 supports bifunctional targeted imaging and photothermal therapy (PTT) for colorectal cancer, offering a simple, biocompatible, hydrophilic, tumor-targetable platform for effective targeted cancer phototherapy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/structure-inherent-tumor-targeted-ir-783-for-near-infrared-fluorescence-guided-photothermal-therapy/339414/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/structure-inherent-tumor-targeted-ir-783-for-near-infrared-fluorescence-guided-photothermal-therapy/339414.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of using IR-783 in this study?","Question",{"text":63,"@type":64},"To assess the phototherapeutic efficacy of IR-783 as a tumor-targeted photothermal agent for photothermal therapy guided by near-infrared fluorescence.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What results were observed after intravenous administration of IR-783?",{"text":68,"@type":64},"IR-783 localized in HT-29 cancer cells and showed preferential accumulation in HT-29 xenografted tumors 24 h after injection.",{"name":70,"@type":61,"acceptedAnswer":71},"How does IR-783 contribute to cancer cell death during photothermal therapy?",{"text":72,"@type":64},"IR-783 converts 808 nm NIR light into heat energy under laser irradiation, leading to cancer cell death in vitro and in vivo.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},339414,1790453963,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Article  \nStructure-Inherent Tumor-Targeted IR-783 for Near-Infrared Fluorescence-Guided Photothermal Therapy  \nYoonbin Park 1,2, Min Ho Park 3,* and Hoon Hyun 1,2, *  \nCitation: Park, Y.; Park, M.H.; Hyun, H. Structure-Inherent Tumor-Targeted IR-783 for Near-Infrared FluorescenceGuided Photothermal Therapy. Int. J. Mol. Sci. 2024, 25, 5309. [https://](https://)[ ](https://)[doi.org/10.3390/ijms25105309](doi.org/10.3390/ijms25105309)  \nAcademic Editor: Shailesh Singh  \nReceived: 21 April 2024  \nRevised: 9 May 2024  \nAccepted: 13 May 2024  \nPublished: 13 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Republic of Korea; [unb1n0213@naver.com](unb1n0213@naver.com)  \n2 BioMedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Republic of Korea  \n3 Department of Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea  \n* [Correspondence: mhpark@chonnam.ac.kr](Correspondence: mhpark@chonnam.ac.kr) (M.H.P.); [hhyun@chonnam.ac.kr](hhyun@chonnam.ac.kr) (H.H.); Tel.: +82-61-379-7646 (M.H.P.); +82-61-379-2652 (H.H.)  \nAbstract: IR-783, a commercially available near-infrared (NIR) heptamethine cyanine dye, has been used for selective tumor imaging in breast, prostate, cervical, and brain cancers in vitro and in vivo. Although the molecular mechanism behind the structure-inherent tumor targeting of IR-783 has not been well-demonstrated, IR-783 has unique properties such as a good water solubility and low cytotoxicity compared with other commercial heptamethine cyanine dyes. The goal of this study is to evaluate the phototherapeutic efficacy of IR-783 as a tumor-targeted photothermal agent inhuman colorectal cancer xenografts. The results demonstrate that IR-783 shows both the subcellular localization in HT-29 cancer cells and preferential accumulation in HT-29 xenografted tumors 24 h after its intravenous administration. Furthermore, the IR-783 dye reveals the superior capability to convert NIR light into heat energy under 808 nm NIR laser irradiation in vitro and in vivo, thereby inducing cancer cell death. Taken together, these findings suggest that water-soluble anionic IR-783 can be used as a bifunctional phototherapeutic agent for the targeted imaging and photothermal therapy (PTT) of colorectal cancer. Therefore, this work provides a simple and effective approach to develop biocompatible, hydrophilic, and tumor-targetable PTT agents for targeted cancer phototherapy.  \nKeywords: IR-783; heptamethine cyanine dyes; photothermal therapy; near-infrared fluorescence imaging; tumor targeting  \n1. Introduction  \nPhotothermal therapy (PTT) is emerging as a safe, effective, noninvasive, and inexpensive modality for treating various types of cancer, compared to traditional treatment approaches such as surgery, chemotherapy, and radiotherapy. Basically, PTT relies on photothermal transduction agents for converting light energy into local hyperthermia, leading to cancer cell death [1,2] . When photons radiated by a near-infrared (NIR) method collide with small-molecule chromophores, electrons are excited from their ground state (S 0) to a higher singlet state (S 1) . Then, they are relaxed to the lowest excited state through internal conversion. The relaxed molecules at the lowest vibrational level of the excited state can decay back to the ground state (heat generation) following the non-radiative relaxation path. The photothermal effects are generally the result of the attenuation of non-radiative relaxation paths [3] . Currently, most PTT methods have foc","cbCaiiUuSDoKYGs2","https://ap.wps.com/l/cbCaiiUuSDoKYGs2","pdf",2663219,"English","# Introduction\n## Photothermal therapy overview\n## Optical mechanism of photothermal transduction\n## NIR advantages for tumor treatment\n## Importance of tumor accumulation of PTT agents\n## Cyanine dyes as tumor-targeted phototherapeutic candidates\n## Prior heptamethine cyanine dyes and structure-inherent targeting","[{\"question\":\"What is the main purpose of using IR-783 in this study?\",\"answer\":\"To assess the phototherapeutic efficacy of IR-783 as a tumor-targeted photothermal agent for photothermal therapy guided by near-infrared fluorescence.\"},{\"question\":\"What results were observed after intravenous administration of IR-783?\",\"answer\":\"IR-783 localized in HT-29 cancer cells and showed preferential accumulation in HT-29 xenografted tumors 24 h after injection.\"},{\"question\":\"How does IR-783 contribute to cancer cell death during photothermal therapy?\",\"answer\":\"IR-783 converts 808 nm NIR light into heat energy under laser irradiation, leading to cancer cell death in vitro and in vivo.\"}]","Structure-Inherent Tumor-Targeted IR-783 for Near-Infrared Fluorescence-Guided Photothermal Therapy | PDF",1790030132,35]