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Prior work links binge drinking to disrupted brain development, but recovery after reduced alcohol use remains insufficiently characterized. This longitudinal NCANDA-A analysis used 690 participants aged 12–29 to test how binge drinking episodes and reductions relate to regional gray and white matter volumes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/structural-brain-recovery-following-reductions-in-adolescent-and-young-adult-binge-drinking-a-longitudinal-ncanda-study/432227/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/structural-brain-recovery-following-reductions-in-adolescent-and-young-adult-binge-drinking-a-longitudinal-ncanda-study/432227.png","ImageObject",300,407,{"name":92,"@type":93},"Grenda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the NCANDA longitudinal study address about binge drinking?","Question",{"text":112,"@type":113},"It examines how binge drinking episodes and reductions in binge drinking relate over time to regional gray and white matter volumes in adolescents and young adults.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What brain changes were associated with higher binge drinking frequency?",{"text":117,"@type":113},"Higher frequency related to decreases in gray matter across frontal, parietal, temporal, and occipital cortices, and to white matter reductions in frontolimbic and frontostriatal pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"Does reducing binge drinking show evidence of recovery?",{"text":121,"@type":113},"Yes. Reductions below each participant’s personal mean drinking were associated with attenuated gray-matter shrinkage, and transitioning from frequent to infrequent binge drinking showed larger corpus callosum volumes compared with sustained frequent binge episodes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},432227,1790822106,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Developmental Cognitive Neuroscience 77 (2026) 101653  \nContents lists available at ScienceDirect  \nDevelopmental Cognitive Neuroscience  \njournal [homepage:](homepage: www.elsevier.com/locate/dcn)[ www.elsevier.com/locate/dcn](homepage: www.elsevier.com/locate/dcn)  \n| Structural brain recovery following reductions in adolescent and young adult binge drinking: A longitudinal NCANDA study\u003Cbr>Marybel R. Gonzalez a,* , Ty Brumback b, Madison K. Wickershiemc, Edith V. Sullivan d, Adolf Pfefferbaum d,e, Duncan B. Clark f, David B. Goldstong, M.J. Meloy c, Firas Naberh, Eva M. Müller-Oehringe,i, Angelica M. Morales j, Fiona C. Baker e, Kate B. Noonerk,\u003Cbr>Bonnie J. Nagel j,l, Kilian M. Pohl d, Kenneth J. Sher m, Sandra A. Brown c,n, Susan F. Tapert c, Wesley K. Thompson h\u003Cbr>a Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH b School of Psychology, Xavier University, Cincinnati, OH\u003Cbr>c Department of Psychiatry, University of California San Diego, La Jolla, CA, United States\u003Cbr>d Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States e Center for Health Sciences, SRI International, Menlo Park, CA, United States\u003Cbr>f Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA\u003Cbr>g Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States h Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK, United States i Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States\u003Cbr>j Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States k Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, United States l Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States m Department of Psychological Science, University of Missouri, Columbia, MO, United States n Department of Psychology, University of California San Diego, La Jolla, CA, United States |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: Adolescence\u003Cbr>Young adults Alcohol trajectories Binge drinking White matter volume\u003Cbr>Gray matter volume |  | Adolescence through young adulthood is a sensitive neurodevelopmental window characterized by ongoing maturation of gray and white matter and heightened vulnerability to alcohol’s neurotoxic effects. Although prior studies link binge drinking with disrupted brain development, the potential for recovery with reduced alcohol use remains underexplored. Using data from 690 participants (ages 12–29) in the National Consortium on Alcohol and NeuroDevelopment in Adolescence to Adulthood (NCANDA-A), we examined the longitudinal impact of binge drinking episodes, and reductions in binge drinking episodes, on regional gray and white matter volumes. Linear mixed-effects models assessed (1) past-year binge drinking frequency, (2) reductions below personal mean binge drinking across time, and (3) transitions in frequency of binge drinking across 10 annual neuroimaging assessments. Results showed that higher binge drinking frequency was associated with decreases in gray matter across frontal, parietal, temporal, and occipital cortices, as well as white matter reductions in frontolimbic and frontostriatal pathways. Reductions below personal mean drinking frequency were also associated with attenuated shrinkage in gray matter volumes. Participants who transitioned from frequent to infrequent binge drinking had significantly larger corpus callosum volumes compared to those with sustained frequent binge episodes. This longitudinal analysis demonstrates consistent negative effects of binge drinking on gray and white matter regions. Importantly, reductions in binge drinking provide evidence for neuroanatomical recovery, particularly in the corpus callosum, and suggest that the de","cbCaiegjxpLIO8R3","https://ap.wps.com/l/cbCaiegjxpLIO8R3","pdf",2249965,"English","# Introduction\n## Neurodevelopmental vulnerability in adolescence through early adulthood\n## Alcohol use and binge drinking definitions\n## Longitudinal approach and aims","[{\"question\":\"What question does the NCANDA longitudinal study address about binge drinking?\",\"answer\":\"It examines how binge drinking episodes and reductions in binge drinking relate over time to regional gray and white matter volumes in adolescents and young adults.\"},{\"question\":\"What brain changes were associated with higher binge drinking frequency?\",\"answer\":\"Higher frequency related to decreases in gray matter across frontal, parietal, temporal, and occipital cortices, and to white matter reductions in frontolimbic and frontostriatal pathways.\"},{\"question\":\"Does reducing binge drinking show evidence of recovery?\",\"answer\":\"Yes. Reductions below each participant’s personal mean drinking were associated with attenuated gray-matter shrinkage, and transitioning from frequent to infrequent binge drinking showed larger corpus callosum volumes compared with sustained frequent binge episodes.\"}]","Structural Brain Recovery Following Reductions in Adolescent and Young Adult Binge Drinking - A Longitudinal NCANDA Study | PDF",1790658656,23]