[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384000-105":59,"doc-detail-384000-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","stromal-cells-in-the-tumor-microenvironment-accomplices-of-tumor-progression","Stromal cells in the tumor microenvironment - accomplices of tumor progression?","","The review explains how the tumor microenvironment (TME) integrates cancer cells, immune cells, stromal cells, and extracellular matrix to drive tumor genesis, development, metastasis, and resistance to anti-tumor therapies. It highlights stromal cells as a major TME component that can be recruited or formed via transdifferentiation, influencing metabolism, growth, immune evasion, angiogenesis, and drug resistance. The article also presents the dual roles of stromal cells and outlines treatment strategies based on targeting stromal cell subsets such as CAFs, MSCs, CAAs, TECs, and pericytes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/stromal-cells-in-the-tumor-microenvironment-accomplices-of-tumor-progression/384000/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/stromal-cells-in-the-tumor-microenvironment-accomplices-of-tumor-progression/384000.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What components make up the tumor microenvironment (TME)?","Question",{"text":113,"@type":114},"The TME consists of cells and the extracellular matrix. Cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do stromal cells contribute to tumor progression and therapy resistance?",{"text":118,"@type":114},"Stromal cells regulate tumor metabolism, growth, metastasis, immune evasion, and resistance to anti-tumor therapy through secreted factors, exosomes, and their roles in angiogenesis and extracellular matrix remodeling.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are stromal-cell targeting approaches considered for tumor treatment?",{"text":122,"@type":114},"The review notes that targeting tumor-associated stromal cells may treat tumors by interfering with stromal-cell influence on tumorigenesis and development, while also emphasizing that many strategies against stromal elements still need improved efficacy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},384000,1790316259,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":26},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","[www.nature.com/cddis](www.nature.com/cddis)  \nREVIEW ARTICLE OPEN   \nStromal cells in the tumor microenvironment: accomplices of tumor progression?  \nYan Zhao 1,5, Meili Shen2,5, Liangqiang Wu3, Haiqin Yang3, Yixuan Yao3, Qingbiao Yang3, Jianshi Du4, Linlin Liu2, Yapeng Li3 ✉ and Yuansong Bai 1 ✉  \n© The Author(s) 2023  \n\n|  | The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells. These three types of cells establish complex signals in the body and further influence tumor genesis, development, metastasis and participate in resistance to anti-tumor therapy. It has attracted scholars to study immune cells in TME due to the significant efficacy of immune checkpoint inhibitors (ICI) and chimeric antigen receptor T (CAR-T) in solid tumors and hematologic tumors. After more than 10 years of efforts, the role of immune cells in TME and the strategy of treating tumors based on immune cells have developed rapidly. Moreover, ICI have been recommended by guidelines as first- or second-line treatment strategies in a variety of tumors. At the same time, stromal cells is another major class of cellular components in TME, which also play a very important role in tumor metabolism, growth, metastasis, immune evasion and treatment resistance. Stromal cells can be recruited from neighboring non-cancerous host stromal cells and can also be formed by transdifferentiation from stromal cells to stromal cells or from tumor cells to stromal cells. Moreover, they participate in tumor genesis, development and drug resistance by secreting various factors and exosomes, participating in tumor angiogenesis and tumor metabolism, regulating the immune response in TME and extracellular matrix. However, with the deepening understanding of stromal cells, people found that stromal cells not only have the effect of promoting tumor but also can inhibit tumor in some cases. In this review, we will introduce the origin of stromal cells in TME as well as the role and specific mechanism of stromal cells in tumorigenesis and tumor development and strategies for treatment of tumors based on stromal cells. We will focus on tumor-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), tumor-associated adipocytes (CAAs), tumor |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| endothelial cells (TECs) and pericytes (PCs) in stromal cells. |  |  |\n|  | Cell Death and Disease (2023)14:587; [https://doi.org/10.1038/s41419-023-061](https://doi.org/10.1038/s41419-023-061)10-6 |  |\n|  |  |  |\n\nFACTS  \n● The TME is made up of cells and extracellular matrix (noncellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.  \n● Stromal cells is a major class of cellular components in TME, which also play a very important role in tumor metabolism, growth, metastasis, immune evasion and treatment resistance.  \n● It is possible to target tumor-associated stromal cell (TASCs) to treat tumors based on the influence of TASCs on tumorigenesis and development.  \nOPEN QUESTIONS  \n● So far, no specific markers have been found in stromal cells in TASC, and finding TASC-specific markers will be more helpful in identifying TASC and targeting TASC for tumor treatment.  \n● TASCs such as CAFs can be divided into multiple subtypes according to different methods, however, the understanding of CAF subtypes mainly comes from the different classifications of individual experimental teams, and objective and consistent knowledge of their subtypes is required.  \n● In addition to anti-angiogenic drugs targeting TECs, other strategies targeting stromal cells for tumor therapy have limited efficacy, and how to improve efficacy needs to be further explored.","cbCaiczoePdcGBmH","https://ap.wps.com/l/cbCaiczoePdcGBmH","pdf",2265551,24,"English","# Introduction\n# Facts and Open Questions\n# Stromal cell roles in tumor progression\n## Targeting tumor-associated stromal cells\n# Treatment strategies based on stromal cells","[{\"question\":\"What components make up the tumor microenvironment (TME)?\",\"answer\":\"The TME consists of cells and the extracellular matrix. Cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.\"},{\"question\":\"How do stromal cells contribute to tumor progression and therapy resistance?\",\"answer\":\"Stromal cells regulate tumor metabolism, growth, metastasis, immune evasion, and resistance to anti-tumor therapy through secreted factors, exosomes, and their roles in angiogenesis and extracellular matrix remodeling.\"},{\"question\":\"Why are stromal-cell targeting approaches considered for tumor treatment?\",\"answer\":\"The review notes that targeting tumor-associated stromal cells may treat tumors by interfering with stromal-cell influence on tumorigenesis and development, while also emphasizing that many strategies against stromal elements still need improved efficacy.\"}]","Stromal cells in the tumor microenvironment - accomplices of tumor progression? | PDF",1790260661]