[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380617-105":59,"doc-detail-380617-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","stroke-as-initial-manifestation-of-non-small-cell-lung-cancer-with-trousseau-syndrome","Stroke as initial manifestation of non-small cell lung cancer with Trousseau syndrome","","Stroke is a rare yet fatal complication in advanced malignancy, particularly when it emerges as an initial symptom in non-small cell lung cancer. A retrospective analysis of 10 patients with NSCLC and Trousseau syndrome (2015–2021) evaluated clinical features, imaging findings, treatments, and oncological outcomes, including narratives of two representative cases. All patients had initial neurological presentations, and survival outcomes were assessed with attention to antiplatelet and antitumor therapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/stroke-as-initial-manifestation-of-non-small-cell-lung-cancer-with-trousseau-syndrome/380617/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/stroke-as-initial-manifestation-of-non-small-cell-lung-cancer-with-trousseau-syndrome/380617.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of this study on stroke and non-small cell lung cancer?","Question",{"text":113,"@type":114},"To describe clinical characteristics, treatment approaches, and prognosis in patients with non-small cell lung cancer who present initially with acute multiple cerebral infarction associated with Trousseau syndrome.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients with Trousseau syndrome and NSCLC identified and analyzed?",{"text":118,"@type":114},"Ten patients diagnosed with Trousseau syndrome and NSCLC between 2015 and 2021 at Guangdong Sanjiu Brain Hospital were retrospectively collected and analyzed based on clinical features, imaging, treatments, and oncological outcomes.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatments were commonly used, and how did they relate to outcomes?",{"text":122,"@type":114},"All 10 patients received antiplatelet therapy, and six later received anti-cancer treatment. Patients who received antitumor therapy, especially those with driver gene mutations treated with tyrosine kinase inhibitors, showed better neurological recovery and improved oncological prognosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380617,1790388677,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Hong et al. BMC Cancer (2023) 23:1096 [https://doi.org/10.1186/s12885-023-11627-2](https://doi.org/10.1186/s12885-023-11627-2)  \nBMC Cancer  \n RESEARCH Open Access  \nStroke as initial manifestation of non-small   cell lung cancer with Trousseau syndrome  \nWeiping Hong1†, Tongtong Zhang2†, Changguo Shan1, Hainan Li3, Tao Lin4, Da Liu4, Junjie Zhen1, Juan Li 1, Mingyao Lai1, Zhaoming Zhou1, Cheng Zhou5, Meijuan Zhou6, Minghua Wang2*, Linbo Cai1* and Lei Wen7*  \nAbstract  \nObjective Stroke is a rare but fatal complication of advanced cancer with Trousseau syndrome, especially as initial symptoms. Here, we report the clinical characteristics, treatment, and prognosis of patients with non-small cell lung cancer (NSCLC) who initially presenting with acute multiple cerebral infarction.  \nMethods The clinical characteristics, imaging, treatment, and oncological outcomes of 10 patients diagnosed  \nwith Trousseau syndrome and NSCLC between 2015 and 2021 at Guangdong Sanjiu Brain Hospital were retrospectively collected and analyzed. The clinical course of two typical cases were presented.  \nResults All 10 patients with pathologically confirmed lung adenocarcinoma initially presented with neurological symptoms, including hemiplegic paralysis (7 patients, 70%), dizziness (5 patients, 50%), and unclear speech (3 patients, 30%) . The median age was 63.5 years. Eight and two cases were stage III and IV, respectively, at the initial diagnosis.  \nFive patients underwent driver gene testing, revealing three patients with EGFR-sensitive mutations, one patient with ALK fusion, and one patient with wild-type EGFR. All 10 patients received antiplatelet therapy, and six patients subsequently received anti-cancer treatment. The median overall survival of the patients was 8.5 months (95% confidence interval) and 1-year survival rate was 57. 1% . Patients who received antitumor treatment, especially those harboring driver gene mutations and received tyrosine kinase inhibitors, had better neurological symptom recovery and superior oncological prognosis (median overall survival, not reached versus 7.4 months, p = 0 . 038) .  \nConclusion Trousseau syndrome, presenting as multiple cerebral infarctions, is a rare complication of lung adenocarcinoma. Both antiplatelet and antitumor treatment are recommended to achieve better neurological recovery and oncological prognosis in these patients.  \nKeywords Stroke, Lung Adenocarcinoma, Trousseau Syndrome  \n†Weiping Hong and Tongtong Zhang contributed equally to this work.  \n*Correspondence: Minghua Wang [372075644@qq.com](372075644@qq.com)[ ](372075644@qq.com)Linbo Cai [cailinbo999@163.com](cailinbo999@163.com)[ ](cailinbo999@163.com)Lei Wen [wenlei1998@sina.com](wenlei1998@sina.com)  \n1 Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai North Road, Guangdong 510510, Guangzhou, China  \n2 Department of Nuclear Medicine, The First Affiliated Hospital of Guizhou Medical University, 58 Guiyi Street, Guizhou 550000, Guiyang, China  \n3 Department of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou, China  \n4 Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, China  \n5 Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China  \n6 Department of Radiation Medicine, School of Public Health, Southern Medical University, Guangzhou, China  \n7 Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, 253 Gongye Dadao, Guangdong 510280, Guangzhou, China  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative ","cbCaid2QcNp0GtDf","https://ap.wps.com/l/cbCaid2QcNp0GtDf","pdf",1673138,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What is the purpose of this study on stroke and non-small cell lung cancer?\",\"answer\":\"To describe clinical characteristics, treatment approaches, and prognosis in patients with non-small cell lung cancer who present initially with acute multiple cerebral infarction associated with Trousseau syndrome.\"},{\"question\":\"How were patients with Trousseau syndrome and NSCLC identified and analyzed?\",\"answer\":\"Ten patients diagnosed with Trousseau syndrome and NSCLC between 2015 and 2021 at Guangdong Sanjiu Brain Hospital were retrospectively collected and analyzed based on clinical features, imaging, treatments, and oncological outcomes.\"},{\"question\":\"What treatments were commonly used, and how did they relate to outcomes?\",\"answer\":\"All 10 patients received antiplatelet therapy, and six later received anti-cancer treatment. Patients who received antitumor therapy, especially those with driver gene mutations treated with tyrosine kinase inhibitors, showed better neurological recovery and improved oncological prognosis.\"}]","Stroke as initial manifestation of non-small cell lung cancer with Trousseau syndrome | PDF",1790240992,23]