[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443134-105":59,"doc-detail-443134-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","striatal-a-symmetry-reveals-sex-specific-autonomic-vulnerabilities-in-early-parkinsons-disease","Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson’s disease","","Autonomic symptoms are common in Parkinson’s disease and vary with patterns of dopaminergic neurodegeneration and early striatal denervation asymmetry. This exploratory study evaluates how striatal denervation asymmetry and sex shape autonomic dysfunction profiles in early-stage, treatment-naive Parkinson’s disease. Using Parkinson’s Progression Markers Initiative data (n = 759), generalized linear mixed models test SCOPA-AUT scores across left-predominant, right-predominant, and symmetric subtypes while modeling sex interactions. Symmetric denervation shows greater overall dysfunction and sex-specific domains, supporting subtype-informed personalized symptom management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/striatal-a-symmetry-reveals-sex-specific-autonomic-vulnerabilities-in-early-parkinsons-disease/443134/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/striatal-a-symmetry-reveals-sex-specific-autonomic-vulnerabilities-in-early-parkinsons-disease/443134.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the exploratory study investigate in early Parkinson’s disease?","Question",{"text":112,"@type":113},"It investigates how striatal denervation asymmetry and sex jointly influence autonomic dysfunction profiles in early-stage, treatment-naive Parkinson’s disease.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data source and outcome measure are used to assess autonomic dysfunction?",{"text":117,"@type":113},"The study uses data from the Parkinson’s Progression Markers Initiative (n = 759) and evaluates autonomic dysfunction using SCOPA-AUT scores.",{"name":119,"@type":110,"acceptedAnswer":120},"How did symmetric striatal denervation relate to autonomic symptoms?",{"text":121,"@type":113},"Patients with symmetric striatal denervation showed significantly greater overall autonomic dysfunction, especially in sexual domains.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443134,1790866142,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","npj | women's health Article  \n\n| \u003Cbr>[https://doi.org/10.1038/s44294-025-00121-8](https://doi.org/10.1038/s44294-025-00121-8) |  |\n| --- | --- |\n| Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson’s disease\u003Cbr> Check for updates |  |\n| Anthony Nuber-Champier1,2 & Julie Anne Péron1,2,3  |  |\n| Autonomic symptoms are common in Parkinson’s disease and vary according to patterns of dopaminergic neurodegeneration. The impact of sex and striatal denervation asymmetry are interesting avenues for observing distinct patient phenotypes from the early stagesofthe disease. This exploratory study investigates how striatal denervation asymmetry and sex influence autonomic dysfunction profiles in early-stage, treatment-naive Parkinson’s disease. Using data from the Parkinson’s Progression Markers Initiative (n = 759), we applied generalized linear mixed models to assess SCOPA-AUT scores across subtypes of striatal denervation (left-predominant, rightpredominant, symmetric), modeling the interaction with sex. Patients with symmetric striataldenervation exhibited significantly greater overall autonomic dysfunction, particularly in sexual domains (p = 0.045) . Sex-specific effects emerged: women showed more pronounced thermoregulatory symptoms (p = 0.001), whereas men exhibited more severe urinary and sexual dysfunction, especially in the symmetric group (p \u003C 0.0001) . These findings suggest the potential of integrating striatal denervation asymmetry and sex into Parkinson ’s disease subtype characterization, with implications for personalized symptom management. |  |\n| Parkinson’s disease (PD) is a complex neurodegenerative disorder affecting millions worldwide. It is characterized by hallmark motor symptoms and abroad range of non-motor manifestations, including cognitive decline and autonomic dysfunction, which significantly impact quality of life1,2. Motor symptoms often begin asymmetrically, reflecting underlying dopaminergicdenervation in the striatum3. Despite extensive research, the links between the lateralization ofstriatal neurodegeneration and the heterogeneity of PD symptoms, both motor and non-motor, remain unclear. In recent years, growing attention hasbeen paid to the asymmetry ofneurodegeneration asa potential factor shaping disease expression and progression4–6. The Synuclein Origin and Connectome (SOC) model, proposed by Borghammer4, provides an interesting theoretical framework that distinguishes between two main PD phenotypes: a “brain-first” subtype, characterized by initially asymmetric cerebral involvement, and a “body-first” subtype, marked by more symmetric pathology and prominent autonomic symptoms. However, the role of asymmetry within this model remains debated, and current evidence based solely on dopaminergic imaging does not yet allow clear subtype differentiation7–9. Nevertheless, asymmetry remains a relevant dimension for understanding interindividual variability in PD presentation. | Autonomic symptoms are common in PD and can appear early in the disease course10, 11. They encompass cardiovascular, gastrointestinal, urinary, and thermoregulatory disturbances, and contribute substantially to morbidity and reduced quality of life12, 13. Understanding how these symptoms vary according to underlying dopaminergic patterns could help clarify mechanisms of dysautonomia in PD. Preliminary work, for example, suggests that left-predominant striatal denervation may be associated with more pronounced gastrointestinal symptoms compared to rightpredominant or symmetric denervation14 although these findings require replication in larger and more homogeneous samples.\u003Cbr>Another factor that may influence PD expression is sex. Increasing evidence indicates that men and women differ in disease risk, progression, and symptom profiles15, 16. In particular, women often report a greater burden ofnon-motor and autonomic symptoms, such as gastrointestinal or thermoregulatory disturbances17, 18. Hormonal diffe","cbCaihnDzXZwsZZp","https://ap.wps.com/l/cbCaihnDzXZwsZZp","pdf",545074,"English","# Background\n## Dopaminergic asymmetry and PD heterogeneity\n## Autonomic symptoms in early PD\n# Sex as a modifier\n## Differences in risk and symptom profiles\n## Estrogen and hormone-related mechanisms\n# Study design and analysis\n## PPMI cohort and treatment-naive participants\n## SCOPA-AUT outcomes and statistical modeling\n# Key findings and implications","[{\"question\":\"What question does the exploratory study investigate in early Parkinson’s disease?\",\"answer\":\"It investigates how striatal denervation asymmetry and sex jointly influence autonomic dysfunction profiles in early-stage, treatment-naive Parkinson’s disease.\"},{\"question\":\"Which data source and outcome measure are used to assess autonomic dysfunction?\",\"answer\":\"The study uses data from the Parkinson’s Progression Markers Initiative (n = 759) and evaluates autonomic dysfunction using SCOPA-AUT scores.\"},{\"question\":\"How did symmetric striatal denervation relate to autonomic symptoms?\",\"answer\":\"Patients with symmetric striatal denervation showed significantly greater overall autonomic dysfunction, especially in sexual domains.\"}]","Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson’s disease | PDF",1790703023]