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The work reviews core physiological systems such as hormonal and neurobiological stress response pathways, reward circuitry, opioid mechanisms, and genetic influences. It also addresses how early life stress shapes vulnerability, and how negative affect and psychosocial factors interact with substance use across initiation, maintenance, and relapse stages.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/stress-and-addiction-biological-and-psychological-mechanisms/129236/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/stress-and-addiction-biological-and-psychological-mechanisms/129236.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-20","2026-08-06",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"本书重点研究了哪些与“压力-成瘾”相关的生物机制？","Question",{"text":112,"@type":113},"书中系统梳理压力反应的生物学基础，包括激素轴（如HPA轴）、奖赏相关多巴胺通路、内源性阿片系统及其与成瘾相关的相互作用，以及神经生物学层面的复发风险机制。","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"压力如何影响成瘾的获取、维持与复发？",{"text":117,"@type":113},"通过章节对HPA轴与成瘾获得的关联、压力对用药维持的作用，以及压力诱导的复发相关神经生物学变化进行讨论，从而说明压力在成瘾进程中的关键作用。",{"name":119,"@type":110,"acceptedAnswer":120},"哪些心理社会因素在成瘾过程中发挥作用？",{"text":121,"@type":113},"围绕“负性情绪（Negative Affect）”展开，结合物质期待、用药的启动阶段、维持阶段与复发阶段，说明负性情绪如何与成瘾行为相互促进并影响结局。","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},129236,1786013411,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":129,"read_time":144},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","STRESS AND ADDICTION Biological and Psychological Mechanisms  \nThis Page Intentionally Left Blank  \nSTRESS AND ADDICTION  \nBiological and Psychological Mechanisms  \nEdited by Mustafa al’Absi, Ph.D.  \nUniversity of Minnesota Medical School Duluth, MN, USA  \nAMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO  \nAcademic Press is an imprint of Elsevier  \nAcademic Press is an imprint of Elsevier  \n30 Corporate Drive, Suite 400, Burlington, MA 01803, USA  \n525 B Street, Suite 1900, San Diego, California 92101-4495, USA  \n84 Theobald’s Road, London WC1X 8RR, UK This book is printed on acid-free paper.∞  \nCopyright © 2007, Elsevier Ltd. All rights reserved.  \nNo part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher.  \nPermissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, E-mail:  \n[permissions@elsevier.com. You may also complete your](permissions@elsevier.com. You may also complete your) request on-line via the Elsevier homepage ([http://elsevier.com](http://elsevier.com)), by selecting “Support & Contact” then “Copyright and Permission” and then “Obtaining Permissions.”  \nLibrary of Congress Cataloging-in-Publication Data  \nApplication submitted  \nBritish Library Cataloguing-in-Publication Data  \nA catalogue record for this book is available from the British Library.  \nISBN 13: 978-0-12-370632-4  \nISBN 10: 0-12-370632-7  \nFor information on all Academic Press publications [visit our Web site at www.books.elsevier.com](visit our Web site at www.books.elsevier.com)  \nPrinted in the United States of America  \n06 07 08 09 10 9 8 7 6 5 4 3 2 1  \nContents  \nContributors xi  \nForeword by George F. Koob xv  \nPreface xvii  \nAcknowledgments xix  \nSECTION I. NEUROBIOLOGY OF STRESS AND ADDICTION  \n1. Biological Bases of the Stress Response 3 Brigitte M. Kudielka and Clemens Kirschbaum  \nI. Introduction 3  \nII. Physiological Stress Research 4  \nIII. Major Components of the Biological Stress Response System 7  \nIV. Other Stress-Responsive Hormone Axes 10  \nV. Other Stress-Responsive Systems 12  \nVI. Final Remarks 15 References 15  \n2. The Hypothalamic-Pituitary-Adrenal Axis and Addiction 21 Nicholas E. Goeders  \nI. Introduction 21  \nII. Stress and the HPA Axis 22  \nIII. Stress, the HPA Axis, and the Acquisition of Drug Taking 23  \nIV. Stress and Vulnerability to Addiction in Humans 25  \nV. The HPA Axis and the Maintenance of Drug Taking 26  \nVI. Relapse to Addiction 28  \nVII. Inconsistencies 30  \nVIII. Conclusions and Implications for the Treatment of Addiction 33 References 35  \nvi CONTENTS  \n3. Dopaminergic Reward Pathways and Effects of Stress 41  \nMichela Marinelli  \nI. Defining Stress 41  \nII. The Mesencephalic Dopamine System 42  \nIII. Dopamine and Addiction 48  \nIV. Dopamine and Stress 52  \nV. Conclusions 63 References 67  \n4. Endogenous Opiates, Addiction, and the Stress Response 85 Rachel Y. Chong, Magdalena Uhart, and Gary S. Wand  \nI. Introduction 85  \nII. The Endogenous Opioid System 86  \nIII. The Endogenous Opioid System and Reward and Reinforcement 86  \nIV. Effect of Alcohol on Endogenous Opioid Activity 87  \nV. Effect of Alcohol on Endogenous Opioid Receptors 88  \nVI. Endogenous Opioid Activity and Receptors and Alcohol Preference 88  \nVII. Opioid Antagonists in the Treatment of Alcohol Addiction 90  \nVIII. Endogenous Opioid Activity and Receptors and Cocaine Preference 91  \nIX. Opioid Antagonists in the Treatment of Cocaine Addiction 91  \nX. Opioids and Risk for Alcoholism 92  \nXI. The μ-Opioid Receptor Gene 95  \nXII. Conclusions 97 References 97  \n5. Early Life Stress and Vulnerability to Addiction 105  \nTherese A. Kosten and Priscilla Kehoe  \nI. Introduction 105  \nII. Neurohor","cbCaiaLSgGQaXPse","https://ap.wps.com/l/cbCaiaLSgGQaXPse","pdf",4360863,453,"English","# SECTION I. NEUROBIOLOGY OF STRESS AND ADDICTION\n## Biological Bases of the Stress Response\n## The Hypothalamic-Pituitary-Adrenal Axis and Addiction\n## Dopaminergic Reward Pathways and Effects of Stress\n## Endogenous Opiates, Addiction, and the Stress Response\n## Early Life Stress and Vulnerability to Addiction\n## Genetics, Stress, and the Risk for Addiction\n## Neurobiology of Stress and Risk for Relapse\n# SECTION II. PSYCHOSOCIAL PROCESSES RELATED TO STRESS AND ADDICTION\n## Negative Affect and Addiction","[{\"question\":\"本书重点研究了哪些与“压力-成瘾”相关的生物机制？\",\"answer\":\"书中系统梳理压力反应的生物学基础，包括激素轴（如HPA轴）、奖赏相关多巴胺通路、内源性阿片系统及其与成瘾相关的相互作用，以及神经生物学层面的复发风险机制。\"},{\"question\":\"压力如何影响成瘾的获取、维持与复发？\",\"answer\":\"通过章节对HPA轴与成瘾获得的关联、压力对用药维持的作用，以及压力诱导的复发相关神经生物学变化进行讨论，从而说明压力在成瘾进程中的关键作用。\"},{\"question\":\"哪些心理社会因素在成瘾过程中发挥作用？\",\"answer\":\"围绕“负性情绪（Negative Affect）”展开，结合物质期待、用药的启动阶段、维持阶段与复发阶段，说明负性情绪如何与成瘾行为相互促进并影响结局。\"}]","STRESS AND ADDICTION - Biological and Psychological Mechanisms | PDF",1142]