[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-216930-en":3,"doc-seo-216930-105":31,"detail-sidebar-cat-0-en-105":97},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":28,"seo_description":14,"update_tm":29,"read_time":30},216930,2336474459895,"Gloria","https://ap-avatar.wpscdn.com/avatar/22000baeef7a5ed0655?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786071322749376916",7,"Healthcare","Streptomycin Injection - Important Safety Information and Clinical Pharmacology","Streptomycin for Injection is an aminoglycoside antibiotic supplied as a sterile lyophilized cake for intramuscular use after reconstitution. The prescribing information emphasizes use only for infections proven or strongly suspected to be bacterial in origin, and highlights sharply increased risks of severe neurotoxic reactions in patients with impaired renal function or pre-renal azotemia. It outlines monitoring of renal function, dose considerations, avoidance of concurrent or sequential nephrotoxic and neurotoxic drugs, and expected pharmacokinetics after intramuscular administration, including tissue distribution and excretion by glomerular filtration.","STREPTOMYCIN-streptomycin injection, powder, lyophilized, for solution XGen Pharmaceuticals DJB, Inc .  \n----------  \nStreptomycin for Injection, USP  \n1 gram*/vial  \n*Each vial contains Streptomycin Sulfate USP equivalent to 1 gram Streptomycin  \nFor Intramuscular Use  \nTo reduce the development of drug-resistant bacteria and maintain the effectiveness of streptomycin and other antibacterial drugs , streptomycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.  \nWARNING  \nTHE RISK OF SEVERE NEUROTOXIC REACTIONS IS SHARPLY INCREASED INPATIENTS WITH IMPAIRED RENAL FUNCTION OR PRE-RENAL AZOTEMIA. THESE INCLUDE DISTURBANCES OF VESTIBULAR AND COCHLEAR FUNCTION , OPTIC NERVE DYSFUNCTION , PERIPHERAL NEURITIS, ARACHNOIDITIS, AND ENCEPHALOPATHY MAY ALSO OCCUR. THE INCIDENCE OF CLINICALLY DETECTABLE, IRREVERSIBLE VESTIBULAR DAMAGE IS PARTICULARLY HIGH INPATIENTS TREATED WITH STREPTOMYCIN.  \nRENAL FUNCTION SHOULD BE MONITORED CAREFULLY; PATIENTS WITH RENAL IMPAIRMENT AND/OR NITROGEN RETENTION SHOULD RECEIVE REDUCED DOSES. THE PEAK SERUM CONCENTRATION IN INDIVIDUALS WITH KIDNEY DAMAGE SHOULD NOT EXCEED 20 TO 25 MCG/ML.  \nTHE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/ORNEPHROTOXIC DRUGS WITH STREPTOMYCIN SULFATE, INCLUDING NEOMYCIN , KANAMYCIN , GENTAMICIN , CEPHALORIDINE, PAROMOMYCIN , VIOMYCIN , POLYMYXIN B, COLISTIN , TOBRAMYCIN AND CYCLOSPORINE SHOULD BE AVOIDED.  \nTHE NEUROTOXICITY OF STREPTOMYCIN CAN RESULT IN RESPIRATORY PARALYSIS FROM NEUROMUSCULAR BLOCKAGE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER THE USE OF ANESTHESIA OR MUSCLE RELAXANTS. THE ADMINISTRATION OF STREPTOMYCIN IN PARENTERAL FORM SHOULD BE RESERVED FOR PATIENTS WHERE ADEQUATE LABORATORY AND AUDIOMETRIC TESTING FACILITIES ARE AVAILABLE DURING THERAPY.  \nDESCRIPTION  \nStreptomycin is a water-soluble aminoglycoside derived from Streptomyces griseus. It is marketed as the sulfate salt of streptomycin. The chemical name of streptomycin sulfate is D-Streptamine, O-2-deoxy-2-(methylamino) - α-L-glucopyranosyl-(1→2) -O-5-deoxy-3-C-formyl- α-L-lyxofuranosyl-(1→4)-N,N 1-bis(aminoiminomethyl)- ,sulfate (2:3) (salt) . The molecular formula for Streptomycin Sulfate is (C 21H 39N 7O 12) 2 • 3H 2SO 4 and the molecular weight is 1457.41. It has the following structural formula:  \nStreptomycin for Injection, equivalent to 1 gram streptomycin/vial, is supplied as a sterile nonpyrogenic lyophilized cake for intramuscular use after reconstitution. The lyophilized cake may reduce to a powder during shipping.  \nAfter reconstitution, the pH range for Streptomycin for Injection should be between 4.5 and 7 in a solution containing 200 mg of streptomycin activity per mL.  \n*Each vial of Streptomycin for Injection contains streptomycin sulfate equivalent to 1 gram of streptomycin.  \nCLINICAL PHARMACOLOGY  \nFollowing intramuscular injection of 1 g of streptomycin as the sulfate, a peak serum level of 25 to 50 mcg/mL is reached within 1 hour , diminishing slowly to about 50 percent after 5 to 6 hours .  \nAppreciable concentrations are found in all organ tissues except the brain. Significant amounts have been found in pleural fluid and tuberculous cavities . Streptomycin passes through the placenta with serum levels in the cord blood similar to maternal levels . Small amounts are excreted in milk, saliva, and sweat.  \nStreptomycin is excreted by glomerular filtration. In patients with normal kidney function, between 29% and 89% of a single 600 mg dose is excreted in the urine within 24 hours . Any reduction of glomerular function results in decreased excretion of the drug and concurrent rise in serum and tissue levels .  \nMicrobiology  \nStreptomycin sulfate is a bactericidal antibiotic . It acts by interfering with normal protein synthesis .  \nStreptomycin has been shown to be active against most strains of the following organisms both in vitro and in clinical infection. (See INDICATIONS AND USAGE. ) :  \nBrucella (b","cbCaiqJac1buuou9","https://ap.wps.com/l/cbCaiqJac1buuou9","pdf",708944,2,1,12,"English","en",105,"# Warnings and Precautions\n## Neurotoxicity and Renal Impairment\n## Drug Interactions and Administration Considerations\n# Description\n## Composition and Reconstitution\n## pH Range\n# Clinical Pharmacology\n## Serum Levels and Distribution\n## Excretion and Kidney Function","[{\"question\":\"What major safety risk is emphasized for streptomycin, and who is at highest risk?\",\"answer\":\"The document highlights a sharply increased risk of severe neurotoxic reactions in inpatients with impaired renal function or pre-renal azotemia.\"},{\"question\":\"How should renal function be managed during streptomycin therapy?\",\"answer\":\"Renal function should be monitored carefully, and patients with renal impairment and/or nitrogen retention should receive reduced doses.\"},{\"question\":\"What is streptomycin’s mechanism of action and general antimicrobial activity?\",\"answer\":\"Streptomycin is a bactericidal antibiotic that acts by interfering with normal protein synthesis and is active against many listed organisms in vitro and in clinical infections.\"}]","Streptomycin Injection - Important Safety Information and Clinical Pharmacology | PDF",1788828401,30,{"code":4,"msg":32,"data":33},"ok",{"site_id":25,"language":24,"slug":34,"title":13,"keywords":35,"description":14,"schema_data":36,"social_meta":92,"head_meta":94,"extra_data":96,"updated_unix":29},"streptomycin-injection-important-safety-information-and-clinical-pharmacology","",{"@graph":37,"@context":91},[38,54,74],{"@type":39,"itemListElement":40},"BreadcrumbList",[41,45,48,51],{"item":42,"name":43,"@type":44,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":46,"name":47,"@type":44,"position":20},"https://docshare.wps.com/document/","Document",{"item":49,"name":12,"@type":44,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":44,"position":53},"https://docshare.wps.com/document/streptomycin-injection-important-safety-information-and-clinical-pharmacology/216930/",4,{"url":52,"name":13,"@type":55,"image":56,"author":61,"headline":13,"publisher":63,"fileFormat":66,"inLanguage":24,"description":14,"dateModified":67,"datePublished":68,"encodingFormat":66,"isAccessibleForFree":69,"interactionStatistic":70},"DigitalDocument",{"url":57,"@type":58,"width":59,"height":60},"https://docshare.wps.com/thumbnails/streptomycin-injection-important-safety-information-and-clinical-pharmacology/216930.png","ImageObject",300,407,{"name":9,"@type":62},"Person",{"url":42,"name":64,"@type":65},"DocShare","Organization","application/pdf","2026-09-11","2026-09-08",true,{"@type":71,"interactionType":72,"userInteractionCount":20},"InteractionCounter",{"@type":73},"ViewAction",{"@type":75,"mainEntity":76},"FAQPage",[77,83,87],{"name":78,"@type":79,"acceptedAnswer":80},"What major safety risk is emphasized for streptomycin, and who is at highest risk?","Question",{"text":81,"@type":82},"The document highlights a sharply increased risk of severe neurotoxic reactions in inpatients with impaired renal function or pre-renal azotemia.","Answer",{"name":84,"@type":79,"acceptedAnswer":85},"How should renal function be managed during streptomycin therapy?",{"text":86,"@type":82},"Renal function should be monitored carefully, and patients with renal impairment and/or nitrogen retention should receive reduced doses.",{"name":88,"@type":79,"acceptedAnswer":89},"What is streptomycin’s mechanism of action and general antimicrobial activity?",{"text":90,"@type":82},"Streptomycin is a bactericidal antibiotic that acts by interfering with normal protein synthesis and is active against many listed organisms in vitro and in clinical infections.","https://schema.org",{"og:url":52,"og:type":93,"og:title":13,"og:site_name":64,"og:description":14},"article",{"robots":95,"canonical":52},"index,follow",{"doc_id":7,"site_id":25},{"code":4,"msg":5,"data":98},[99,103,107,111,116,121,124,128,133,136,140],{"id":21,"doc_module":4,"doc_module_name":47,"category_name":100,"show_sort_weight":101,"slug":102},"Story & Novel",90,"story-novel",{"id":20,"doc_module":4,"doc_module_name":47,"category_name":104,"show_sort_weight":105,"slug":106},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":47,"category_name":108,"show_sort_weight":109,"slug":110},"Exam",70,"exam",{"id":112,"doc_module":4,"doc_module_name":47,"category_name":113,"show_sort_weight":114,"slug":115},5,"Comic",60,"comic",{"id":117,"doc_module":4,"doc_module_name":47,"category_name":118,"show_sort_weight":119,"slug":120},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":47,"category_name":12,"show_sort_weight":122,"slug":123},40,"healthcare",{"id":125,"doc_module":4,"doc_module_name":47,"category_name":126,"show_sort_weight":30,"slug":127},8,"Research & Report","research-report",{"id":129,"doc_module":4,"doc_module_name":47,"category_name":130,"show_sort_weight":131,"slug":132},9,"Religion & Spirituality",20,"religion-spirituality",{"id":131,"doc_module":4,"doc_module_name":47,"category_name":134,"show_sort_weight":131,"slug":135},"World Cup","world-cup",{"id":137,"doc_module":4,"doc_module_name":47,"category_name":138,"show_sort_weight":137,"slug":139},10,"Lifestyle","lifestyle",{"id":141,"doc_module":4,"doc_module_name":47,"category_name":142,"show_sort_weight":112,"slug":143},19,"General","general"]