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Methods use OncoSim-Cervical to simulate HPV transmission and screening pathways for British Columbia from 2023–2050. Results show elimination by 2034 at current uptake levels, and by 2031 with improved on-time screening and follow-up compliance, while vaccination alone yields smaller changes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/strategies-to-accelerate-the-elimination-of-cervical-cancer-in-british-columbia-canada-a-modelling-study/330732/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/strategies-to-accelerate-the-elimination-of-cervical-cancer-in-british-columbia-canada-a-modelling-study/330732.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What elimination target is used for cervical cancer in Canada, and why does it matter?","Question",{"text":63,"@type":64},"Elimination is defined as an annual age-standardized incidence rate (ASIR) below 4.0 per 100,000 women. The study evaluates how priority actions influence the projected time to reach this threshold in British Columbia.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What model and data are used to project cervical cancer incidence and elimination year?",{"text":68,"@type":64},"The analysis uses OncoSim-Cervical, a microsimulation model that simulates HPV transmission and the natural history of cervical cancer for the Canadian population. Model parameters are updated to reflect BC’s historical participation rates and program design.",{"name":70,"@type":61,"acceptedAnswer":71},"Which interventions most accelerate elimination in the projections?",{"text":72,"@type":64},"HPV-based screening at current vaccination, participation, and follow-up rates can eliminate cervical cancer by 2034. Increasing on-time screening and follow-up compliance could achieve elimination by 2031, while increasing vaccination coverage has a smaller impact over the time horizon.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330732,1790190803,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":112,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":118,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Research  Access to health care  \nStrategies to accelerate the elimination of cervical cancer in British Columbia, Canada: a modelling study  \nReka E. Pataky PhD, Sara Izadi-Najafabadi PhD, Laurie W. Smith MPH BN, Anna Gottschlich PhD, Diana Ionescu MD, Lily Proctor MD MPH, Gina S. Ogilvie MD DrPH, Stuart Peacock DPhil  \nn Cite as: CMAJ 2024 June 3;196:E716-23. doi: 10.1503/cmaj.231682 See related [editorial at www.cmaj.ca/lookup/doi/10.1503/cmaj.240722](editorial at www.cmaj.ca/lookup/doi/10.1503/cmaj.240722)  \nAbstract  \nBackground: To eliminate cervical cancer in Canada by 2040, defined as an annual age-standardized incidence rate (ASIR) lower than 4.0 per 100 000 women, the Canadian Partnership Against Cancer (CPAC) identified 3 priorities for action: increasing human papillomavirus (HPV) vaccine coverage, implementing HPVbased screening and increasing screening participation, and improving follow-up after abnormal screen results. Our objective was to explore the impact of these priorities on the projected time to elimination of cervical cancer in British Columbia.  \nMethods: We used OncoSim-Cervical, amicrosimulation model led and sup-  \nported by CPAC and developed by Statistics Canada that simulates HPV transmission and the natural history of cervical cancer for the Canadian population. We updated model parameters to reflect BC’s historical participation rates and program design. We simulated the transition to HPV-based screening and developed scenarios to explore the additional impact of achieving 90% vaccination coverage, 95% screening recruitment, 90% ontime screening, and 95% follow-up compliance. We projected cervical cancer incidence, ASIR, and year of elimination for the population of BC for 2023–2050.  \nResults: HPV-based screening at current vaccination, participation, and follow-up rates can eliminate cervical cancer by 2034. Increasing on-time screening and followup compliance could achieve this target by 2031. Increasing vaccination coverage has a small impact over this time horizon.  \nInterpretation: With the implementation of HPV-based screening, cervical cancer can be eliminated in BC before 2040. Efforts to increase screening participation and follow-up through this transition could potentially accelerate this timeline, but the transition from cytology-to HPV-based screening is fundamental to achieving this goal.  \nA long-term, persistent infection with an oncogenic genotype of the human papillomavirus (HPV) is a necessary condition for the development of cervical cancer. Nine types of high-risk HPV are responsible for more than 90% of cervical cancer cases globally, with 71% caused by HPV types 16 or 18.1 Cervical cancer can be prevented through vaccination against HPV and through early detection and treatment of precancerous lesions with screening. For decades, cytology (Pap testing) has been the primary approach to screening. Cytology-based screening has been a public health success, but since the mid-2000s the incidence of cervical cancer in Canada has remained largely unchanged, with an age-standardized incidence rate (ASIR; 2011 Canadian population) at around 7.1 per 100 000 females.2,3 To further reduce the burden of cervical cancer, interventions to prevent HPV infection and to enhance cervical screening are necessary.  \nIn Canada, publicly funded school-based HPV vaccination programs have been in place for girls starting in 2007, and for boys starting in 2013.4,5 Vaccination against HPV is highly efective at preventing cervical precancer;6 however, the current screen-eligible population is largely unvaccinated, as the first vaccinated cohorts have only recently reached screening age. Primary screening with HPV testing has shown higher sensitivity than cytology for detection of cervical precancer.7,8 Unlike cytology testing, which involves a speculum examination by a clinician for cervical cell collection, HPV testing can be performed on cervical or self-collected vaginal samples. The option for ","cbCaih73I0MnkNzX","https://ap.wps.com/l/cbCaih73I0MnkNzX","pdf",131330,"English","# Abstract\n## Background\n## Methods\n## Results\n## Interpretation\n# Context and rationale\n## HPV infection and screening approaches\n## Vaccination programs and screening transition\n# Screening and follow-up pathway","[{\"question\":\"What elimination target is used for cervical cancer in Canada, and why does it matter?\",\"answer\":\"Elimination is defined as an annual age-standardized incidence rate (ASIR) below 4.0 per 100,000 women. The study evaluates how priority actions influence the projected time to reach this threshold in British Columbia.\"},{\"question\":\"What model and data are used to project cervical cancer incidence and elimination year?\",\"answer\":\"The analysis uses OncoSim-Cervical, a microsimulation model that simulates HPV transmission and the natural history of cervical cancer for the Canadian population. Model parameters are updated to reflect BC’s historical participation rates and program design.\"},{\"question\":\"Which interventions most accelerate elimination in the projections?\",\"answer\":\"HPV-based screening at current vaccination, participation, and follow-up rates can eliminate cervical cancer by 2034. Increasing on-time screening and follow-up compliance could achieve elimination by 2031, while increasing vaccination coverage has a smaller impact over the time horizon.\"}]","Strategies to accelerate the elimination of cervical cancer in British Columbia, Canada - a modelling study | PDF",1789989868]