[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-459405-105":59,"doc-detail-459405-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","stool-and-plasma-metabolites-and-cognitive-function-in-the-boston-puerto-rican-health-study","Stool and Plasma Metabolites and Cognitive Function in the Boston Puerto Rican Health Study","","Background: Several studies report gut microbiome and plasma metabolome alterations in dementia, yet no studies have examined metabolites in both stool and plasma concurrently. Evidence remains limited in Latinos/Hispanics, who show distinct metabolic and microbiome profiles and face higher dementia risk. Methods: In 314 Boston Puerto Rican Health Study participants (median age 68), concurrent stool and blood were profiled using untargeted metabolomics (Metabolon) and linked to global cognitive score (GCS) with MaAsLin2 and overrepresentation analysis; FDRp \u003C 0.25 was significant. Results: 14 stool and 257 plasma metabolites correlated with GCS, with specific metabolites relating to better or worse cognition and pathway groups enriched. Correlations between stool and plasma were limited, mainly caffeine-related. Conclusion: Plasma metabolome associations align with prior work; further studies are needed for dementia.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/stool-and-plasma-metabolites-and-cognitive-function-in-the-boston-puerto-rican-health-study/459405/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/stool-and-plasma-metabolites-and-cognitive-function-in-the-boston-puerto-rican-health-study/459405.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why does the study focus on both stool and plasma metabolites for cognitive function?","Question",{"text":112,"@type":113},"Prior work linked dementia with gut microbiome and plasma metabolome alterations, but few studies examined metabolites in stool and plasma together. This study explicitly analyzes concurrent stool and blood metabolomic profiles to relate them to cognitive outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data and methods were used to assess the association with global cognitive score (GCS)?",{"text":117,"@type":113},"The study analyzed 314 Boston Puerto Rican Health Study participants who provided concurrent stool and blood samples. Untargeted metabolomic profiling (Metabolon) was performed, and MaAsLin2 with overrepresentation analysis (ORA) was used to identify metabolites and metabolite sets associated with GCS, using an FDRp \u003C 0.25 threshold for significance.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding metabolites associated with better or worse cognition?",{"text":121,"@type":113},"The study identified 14 stool and 257 plasma metabolites associated with GCS. In stool, palmitoleoyl ethanolamide and steviol were associated with better cognition, while lactobacillic acid and stigmasterol were associated with worse cognition. In plasma, gulonate and N-acetylneuraminate were associated with lower GCS, while ergothioneine was associated with higher GCS.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},459405,1790755858,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":24,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","DOI: 10. 1002/alz70856_105357  \nBIOMARKERS  \nPOSTER PRESENTATION  \nBIOMARKERS (NON-NEUROIMAGING)  \nStool and Plasma Metabolites and Cognitive Function in the Boston Puerto Rican Health Study  \nDeepika Dinesh 1  Thomas Kuntz2  Xochitl Morgan3  Tammy M Scott4   \nMahdi Garelnabi5  Katherine L Tucker5  Curtis Huttenhower6  Natalia Palacios7, 8  \n1 Department of Public Health, University of Massachusetts at Lowell, Lowell, MA, USA  \n2 Harvard T. H. Chan School of Public Health, Boston, MA, USA  \n3 Harvard T. H. Chan School of Public Health, Boston, MA, USA  \n4Tufts University, Boston, MA, USA  \n5 Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA  \n6 Harvard T. H. Chan School of Public Health, Boston, MA, USA  \n7 Department of Public Health, University of Massachusetts Lowell, Lowell, MA, USA  \n8 Univ. of MA, Lowell, Lowell, MA, USA  \nCorrespondence  \nNatalia Palacios, Department of Public Health, University of Massachusetts Lowell, Lowell, MA, USA.  \n[Email:](Email: Natalia_Palacios@uml.edu)[ Natalia_Palacios@uml.edu](Email: Natalia_Palacios@uml.edu)  \nAbstract  \nBackground: Several studies have reported alterations in the gut microbiome and plasma metabolome in dementia, but no studies have concurrently examined metabolites in stool and plasma. Evidence is especially lacking in Latinos/Hispanics who have unique metabolic and microbiome profiles and are at an increased risk of dementia.  \nMethods: Our study focused on 314 Boston Puerto Rican Health Study participants (median age 68 y), who provided concurrent stool and blood samples (untargeted metabolomic profiling, Metabolon, Inc) and underwent a comprehensive cognitive assessment, summarized as a global cognitive score (GCS). Multivariate analyses in MaAsLin2 were used to identify stool and plasma metabolites associated with GCS. Overrepresentation analysis (ORA) was used to identify metabolite sets associated with GCS. An FDRp cutoff of \u003C 0. 25 was considered significant.  \nResults: We identified 14 stool and 257 plasma metabolites (89 at FDRp \u003C 0.05) associated with GCS. In stool, palmitoleoyl ethanolamide (pFDR = 0. 15) and steviol (pFDR = 0. 20) were associated with better cognition. Lactobacillic acid (pFDR = 0.09), a microbially derived metabolite, stigmasterol (pFDR = 0.09), and other metabolites were associated with worse cognition. In plasma, gulonate (pFDR= 0.00007), N.acetylneuraminate (FDR= 0.0001) and many others were associated with lower GCS. Ergothioneine, an antioxidant,(FDR = 0.02), among other metabolites, was associated with higher GCS. ORA analyses identified that metabolites within the tyrosine metabolism group pFDR = 0. 2145) in plasma, and long chain saturated fatty acid (pFDR = 0.0003) and tocopherol metabolism (pFDR = 0.0018) groups in stool, were associated with GCS more frequently than expected. Correlations between stool and plasma metabolites were limited and mostly restricted to caffeine-related metabolites.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105357.  \n[https://doi.org/10.1002/alz70856_105357](https://doi.org/10.1002/alz70856_105357)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of2  \nConclusion: Our findings of an association between the plasma metabolome and GCS are consistent with prior studies. More work is needed to examine the stool and plasma metabolomes in dementia.","cbCainPGAhszl3vI","https://ap.wps.com/l/cbCainPGAhszl3vI","pdf",91572,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"Why does the study focus on both stool and plasma metabolites for cognitive function?\",\"answer\":\"Prior work linked dementia with gut microbiome and plasma metabolome alterations, but few studies examined metabolites in stool and plasma together. This study explicitly analyzes concurrent stool and blood metabolomic profiles to relate them to cognitive outcomes.\"},{\"question\":\"What data and methods were used to assess the association with global cognitive score (GCS)?\",\"answer\":\"The study analyzed 314 Boston Puerto Rican Health Study participants who provided concurrent stool and blood samples. Untargeted metabolomic profiling (Metabolon) was performed, and MaAsLin2 with overrepresentation analysis (ORA) was used to identify metabolites and metabolite sets associated with GCS, using an FDRp \\u003c 0.25 threshold for significance.\"},{\"question\":\"What were the main findings regarding metabolites associated with better or worse cognition?\",\"answer\":\"The study identified 14 stool and 257 plasma metabolites associated with GCS. In stool, palmitoleoyl ethanolamide and steviol were associated with better cognition, while lactobacillic acid and stigmasterol were associated with worse cognition. In plasma, gulonate and N-acetylneuraminate were associated with lower GCS, while ergothioneine was associated with higher GCS.\"}]","Stool and Plasma Metabolites and Cognitive Function in the Boston Puerto Rican Health Study | PDF"]