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Central to new strategies is the identification of the hallmarks of cancer, which describe traits driving initiation, development, and progression across diverse tumor types. Conventional drugs can achieve therapeutic efficacy but often cause unfavorable side effects. This review consolidates recent evidence on steroidal saponins as naturally occurring plant secondary metabolites that inhibit cancer hallmarks, while also addressing limitations such as poor bioavailability and the need for more preclinical studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/steroidal-saponins-naturally-occurring-compounds-as-inhibitors-of-the-hallmarks-of-cancer/378098/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/steroidal-saponins-naturally-occurring-compounds-as-inhibitors-of-the-hallmarks-of-cancer/378098.png","ImageObject",300,407,{"name":92,"@type":93},"Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the hallmarks of cancer, and why are they important?","Question",{"text":112,"@type":113},"The hallmarks of cancer are shared traits among most cancers that explain mechanisms behind cancer initiation, development, and progression. 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Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer. Cancers 2023, 15, 3900. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15153900  \nAcademic Editor: David Wong  \nReceived: 9 June 2023  \nRevised: 21 July 2023  \nAccepted: 26 July 2023  \nPublished: 31 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Theranostic Biomarkers, LR23ES02, Faculty of Medicine of Tunis, Universit² Tunis El Manar, Tunis 1006, Tunisia  \n2 Biology Department, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates; [amnamalmaktoum@gmail.com](amnamalmaktoum@gmail.com)  \n* Correspondence: [salwamaster@gmail.com](salwamaster@gmail.com) (S.B.); [a.amin@uaeu.ac.ae](a.amin@uaeu.ac.ae) (A.A.)  \nSimple Summary: Cancer is one of the most life-threatening diseases that affects a rapidly growing number of individuals worldwide. Currently, chemotherapy is the most common method of treating cancer. The unfavorable results involved with existing cancer treatments have motivated the search for novel approaches to treat cancer. Many of these treatments exert their anti-cancer effects by targeting the hallmarks of cancer. The hallmarks of cancer are a set of traits shared among almost all cancers. The increasing knowledge of these characteristics has provided a framework for the development of promising anti-cancer drugs. Historically, nature has been a valuable source for the discovery of effective anti-cancer agents. Steroidal saponins are a group of naturally occurring compounds that have been recently explored for their anti-cancer properties. This review summarizes key findings from recently published articles on the use of steroidal saponins as inhibitors of the hallmarks of cancer.  \nAbstract: Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless of the significant advances in its treatment. The identification of the hallmarks of cancer is a major milestone in understanding the mechanisms that drive cancer initiation, development, and progression. In the past, the hallmarks of cancer have been targeted to effectively treat various types of cancers. These conventional cancer drugs have shown significant therapeutic efficacy but continue to impose unfavorable side effects on patients. Naturally derived compounds are being tested in the search for alternative anti-cancer drugs. Steroidal saponins are a group of naturally occurring compounds that primarily exist as secondary metabolites in plant species. Recent studies have suggested that steroidal saponins possess significant anti-cancer capabilities. This review aims to summarize the recent findings on steroidal saponins as inhibitors of the hallmarksof cancer and covers key studies published between the years 2014 and 2024 . It is reported that steroidal saponins effectively inhibit the hallmarks of cancer, but poor bioavailability and insufficient preclinical studies limit their utilization.  \nKeywords: steroidal saponins; cancer; natural products; hallmarks of cancer; cancer treatment; mechanism of cancer  \n1. Introduction  \nCancer prevails as a global clinical concern accounting for approximately 19 million cases and 10 million deaths in 2020 [1] . It has been estimated that these dire figures will continue to rise regardless of the rapid advances in cancer management and treatment [1] . Cancer is ch","cbCaiv0jevBg1Dm8","https://ap.wps.com/l/cbCaiv0jevBg1Dm8","pdf",5453721,22,"English","# Simple Summary\n# Abstract\n# Keywords\n# Introduction\n## Hallmarks of Cancer as Therapeutic Targets\n## Conventional Cancer Therapies and Limitations\n## Natural Products and Saponins in Anti-Cancer Research","[{\"question\":\"What are the hallmarks of cancer, and why are they important?\",\"answer\":\"The hallmarks of cancer are shared traits among most cancers that explain mechanisms behind cancer initiation, development, and progression. They provide a framework for targeting cancers with therapeutic drugs.\"},{\"question\":\"How do steroidal saponins relate to anti-cancer therapy?\",\"answer\":\"Steroidal saponins are naturally occurring plant secondary metabolites. Recent studies summarized in the review indicate they can inhibit the hallmarks of cancer.\"},{\"question\":\"What limits the use of steroidal saponins in cancer treatment?\",\"answer\":\"The review highlights poor bioavailability and insufficient preclinical studies as key factors limiting their broader utilization.\"}]","Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer | PDF",1790228484,55]