[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332842-105":59,"doc-detail-332842-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","steroid-metabolism-and-hormonal-dynamics-in-normal-and-malignant-ovaries","Steroid metabolism and hormonal dynamics in normal and malignant ovaries","","Steroid metabolism and hormone signaling are central to ovarian function, yet knowledge of steroidogenic enzymes, hormone concentrations, and their roles in healthy and malignant ovaries remains incomplete. The review synthesizes how key steroid enzymes, including STS, 3β-HSD2, HSD17B1, AKR1C3, and aromatase, regulate ovarian steroidal action. It links estrogen- and androgen-receptor pathways to ovarian cancer aggressiveness and subtype-specific variability, highlighting the need to distinguish disease subtypes for future research and therapeutic development.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/steroid-metabolism-and-hormonal-dynamics-in-normal-and-malignant-ovaries/332842/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/steroid-metabolism-and-hormonal-dynamics-in-normal-and-malignant-ovaries/332842.png","ImageObject",300,407,{"name":92,"@type":93},"Evangeline","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are ovaries important for steroid hormone production?","Question",{"text":112,"@type":113},"The ovaries are key steroid hormone production sites that support normal reproductive processes after puberty through local steroid synthesis and signaling.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which enzymes are emphasized as regulators of ovarian steroidal action?",{"text":117,"@type":113},"The review highlights STS, 3β-HSD2, HSD17B1, AKR1C3, and aromatase as key enzymes influencing steroid action in normal and malignant ovaries.",{"name":119,"@type":110,"acceptedAnswer":120},"How might steroid metabolism relate to ovarian cancer progression?",{"text":121,"@type":113},"Some data suggest STS and estrogen receptor α may associate with aggressive ovarian cancer forms, while androgen receptor expression and action vary across cancer subtypes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332842,1790143822,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Essays in Biochemistry (2024) 68 491–507 [https://doi.org/10.1042/EBC20240028](https://doi.org/10.1042/EBC20240028)  \nReview Article  \nSteroid metabolism and hormonal dynamics in normal and malignant ovaries  \nLucy I. Beevors1 , Sudha Sundar2 and  Paul A. Foster1,3  \n1 Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, U. K. ; 2 Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, U. K. ; 3 Centre for Diabetes, Endocrinology, and Metabolism, Birmingham Health Partners, Birmingham, U. K.  \nCorrespondence: Paul A. Foster ([p.a.foster@bham.ac.uk](p.a.foster@bham.ac.uk))  \nReceived: 12 April 2024  \nRevised: 18 June 2024  \nAccepted: 24 June 2024  \nVersion of Record published:  \n04 December 2024  \nThe ovaries are key steroid hormone production sites in post-pubertal females. However, current research on steroidogenic enzymes, endogenous hormone concentrations and their effects on healthy ovarian function and malignant development is limited. Here, we discuss the importance of steroid enzymes in normal and malignant ovaries, alongside hormone concentrations, receptor expression and action. Key enzymes include STS, 3β-HSD2, HSD17B1, ARK1C3, and aromatase, which influence ovarian steroidal action. Both androgen and oestrogen action, via their facilitating enzyme, drives ovarian follicle activation, development and maturation in healthy ovarian tissue. In ovarian cancer, some data suggest STS and oestrogen receptor α may be linked to aggressive forms, while various oestrogen-responsive factors may be involved in ovarian cancer metastasis. In contrast, androgen receptor expression and action vary across ovarian cancer subtypes. For future studies investigating steroidogenesis and steroidal activity in ovarian cancer, it is necessary to differentiate between disease subtypes for a comprehensive understanding.  \nIntroduction  \nSteroids have a major impact on mammalian biology, influencing many processes to maintain homeostasis, regulate metabolism, and control reproduction. Normal ovarian processes, such as follicle growth, oocyte maturation, and ovulation, rely heavily on local steroid production and subsequent localized steroid-mediated signalling. Most of ovarian steroidogenesis occurs under the control of the gonadotropins FSH and LH in the granulosa and theca cells of developing and mature follicles [1] . Conversely, excessive steroidogenesis or heightened steroid signalling within the ovary may precipitate severe ovarian disorders like ovarian cancer (OC) . Recently, our understanding of the intricate mechanisms governing local steroid production and its effects within the ovary have progressed significantly through various in vitro , in vivo , and clinical models. Here, we discuss these findings and examine the importance of sex steroid synthesis and action in the ovary and how this process is dysregulated in different OC types. Ultimately, understanding these processes may lead to new avenues of research and new treatments for ovarian diseases and malignancies.  \nSex steroid synthesis and metabolism in the ovary  \nAlthough it is well known that FSH regulates oestrogen synthesis via aromatase in the ovarian granulosa cell, there is limited knowledge of the expression and function of sex steroid metabolising enzymes across the ovary and their impact on ovarian function. All steroids, including the sex steroids androgens and oestrogens, are derived from cholesterol. The first step, primarily occurring in the adrenal gland, seescholesterol converted topregnenolone by P450scc (cholesterol side-chain cleavage enzyme) encoded by the gene CYP11A1 . It has been known for decades that the ovaries are capable of de novo sex steroid synthesis. Indeed, more recently, CYP11A1expression has been shown inhuman ovarian tissue[2]. However, in general, most active sex steroids are synthesized from circulating adrenal-derived sulfated steroid pre-cursors;  \n© 2024 The Author(s) . This is an o","cbCaiovYiWsOliDE","https://ap.wps.com/l/cbCaiovYiWsOliDE","pdf",2532613,17,"English","# Introduction\n## Sex steroid synthesis and metabolism in the ovary","[{\"question\":\"Why are ovaries important for steroid hormone production?\",\"answer\":\"The ovaries are key steroid hormone production sites that support normal reproductive processes after puberty through local steroid synthesis and signaling.\"},{\"question\":\"Which enzymes are emphasized as regulators of ovarian steroidal action?\",\"answer\":\"The review highlights STS, 3β-HSD2, HSD17B1, AKR1C3, and aromatase as key enzymes influencing steroid action in normal and malignant ovaries.\"},{\"question\":\"How might steroid metabolism relate to ovarian cancer progression?\",\"answer\":\"Some data suggest STS and estrogen receptor α may associate with aggressive ovarian cancer forms, while androgen receptor expression and action vary across cancer subtypes.\"}]","Steroid metabolism and hormonal dynamics in normal and malignant ovaries | PDF",1789999729,43]