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This convenience-sample cross-sectional study evaluates financial toxicity severity in patients with gynecological cancers, quantifies its association with quality of life, and supports targeted clinical interventions to lessen adverse impacts.",{"@graph":14,"@context":76},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/status-of-financial-toxicity-and-its-influence-on-quality-of-life-in-patients-with-gynecological-malignancies-in-china-research-report/350887/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/status-of-financial-toxicity-and-its-influence-on-quality-of-life-in-patients-with-gynecological-malignancies-in-china-research-report/350887.png","ImageObject",300,407,{"name":42,"@type":43},"Patrick","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-25","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68,72],{"name":59,"@type":60,"acceptedAnswer":61},"What is the study’s primary aim?","Question",{"text":62,"@type":63},"To assess the degree of financial toxicity among patients with gynecological cancers and evaluate its influence on quality of life, providing evidence for targeted clinical interventions.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were participants and data collected?",{"text":67,"@type":63},"A convenience sampling approach recruited 281 patients from two hospitals in Nanjing. A cross-sectional survey was conducted between November 2022 and December 2024 using general information questionnaires, a financial toxicity comprehensive scale, and a cancer patient quality-of-life assessment scale.",{"name":69,"@type":60,"acceptedAnswer":70},"What are the main findings about financial toxicity and quality of life?",{"text":71,"@type":63},"Most participants experienced financial toxicity, and the total financial toxicity score showed a significant positive correlation with quality of life (r = 0.553, P \u003C 0.01). Core influencing factors included age of children, family per capita monthly income, recent treatment costs, and marital status.",{"name":73,"@type":60,"acceptedAnswer":74},"Which factors were identified as key influences?",{"text":75,"@type":63},"Multivariate linear regression indicated that the age of children, family per capita monthly income, treatment costs in the past three months, and marital status were the core influencing factors.","https://schema.org",{"og:url":32,"og:type":78,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":80,"canonical":32},"index,follow",{"doc_id":82,"site_id":7},350887,1790300932,{"code":4,"msg":85,"data":86},"success",[87,91,95,99,104,109,114,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":96,"show_sort_weight":97,"slug":98},"Exam",70,"exam",{"id":100,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},5,"Comic",60,"comic",{"id":105,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},6,"Technology",50,"technology",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},7,"Healthcare",40,"healthcare",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":116,"slug":117},8,30,"research-report",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},9,"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":100,"slug":133},19,"General","general",{"code":4,"msg":85,"data":135},{"doc_id":82,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":115,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":143,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":149},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Submitted 23 June 2025  \nAccepted 19 November 2025 Published 15 January 2026  \nCorresponding authors Wanhong Wei, [whwei@yzu.edu.cn](whwei@yzu.edu.cn)[ ](whwei@yzu.edu.cn)Zhen Hong, [hongzhen_hzhz@163.com](hongzhen_hzhz@163.com)  \nAcademic editor Faiza Farhan  \nAdditional Information and Declarations can be found on page 17  \nDOI 10.7717/peerj.20560  \n Copyright 2026 Zhang et al.  \nDistributed under  \nCreative Commons CC-BY-NC 4.0  \nOPEN ACCESS  \nStatus of financial toxicity and its influence on quality of life in patients with gynecological malignancies in China  \nLei Zhang1 ,2 , Yu Zhang3 , Sijing Chen4 , Jingjing Zhang4 , Minmin Song1 , Mingming Hu1 , Lin Liu5 , Ying Kong6 , Lingling Tang6 , Wanhong Wei2 and Zhen Hong1  \n1 School of Nursing, Jiangsu Health Vocational College, Nanjing, China  \n2 College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China  \n3 Department of Oncology, People's Hospital of Jingjiang, Taizhou, China  \n4 Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China  \n5 School of Nursing, School of Public Health, Yangzhou University, Yangzhou, China  \n6 Department of Gynecology and Obstetrics, Nanjing Pukou People's Hospital, Nanjing, China  \nABSTRACT  \nBackground. Gynecological malignancies impose a substantial health and economic burden in China. The high cost of treatment often results in considerable financial toxicity, placing economic strain on patients and their families. These challenges can reduce treatment adherence, heighten emotional distress, and impair quality of life. This study aims to assess the degree of financial toxicity among patients with gynecological cancers, evaluate its impact on quality of life, and provide evidence to support the development of targeted clinical interventions to mitigate its adverse effects.  \nMethods. A convenience sampling approach was employed to recruit 281 patients with gynecological malignancies from two hospitals in Nanjing. A cross-sectional survey was conducted between November 2022 and December 2024 . Data were collected using general information questionnaires, the financial toxicity comprehensive scale, and the cancer patient quality-of-life assessment scale.  \nResults. Data validity was confirmed using Harman's single-factor test (first factor explanatory rate was 30.44%) . The mean 􀀆 SD total financial toxicity score of the patients was 20.80 􀀆 7.32 points, with 73%(205/281) experiencing significant financial burdens. The financial resource dimension had the lowest mean score 3 .40 􀀆 1.37 points. Multivariate linear regression analysis indicated that the age of children, family per capita monthly income, treatment costs in the past three months, and marital status were the core influencing factors (adjusted R2 D 0.310) . The mean 􀀆 SD total quality of life score of the patients was 65.79 􀀆 11.39 points, and the total financial toxicity score was significantly positively correlated with quality of life (r D 0.553, P \u003C 0.01) . Participants had a mean age of 52.27 􀀆 10.78 years; cervical cancer accounted for the highest proportion (49.5%); 29.2% were unemployed or had resigned due to illness, and 96.8% reported medical expenses exceeding CNY 5,000 (roughly $701.50) in the past three months.  \nHow to cite this article Zhang L, Zhang Y, Chen S, Zhang J, Song M, Hu M, Liu L, Kong Y, Tang L, Wei W, Hong Z. 2026. Status of financial toxicity and its influence on quality of life in patients with gynecological malignancies in China. PeerJ 14:e20560  \n[http://doi.org/10.7717/peerj.20560](http://doi.org/10.7717/peerj.20560)  \nConclusion. The majority of studied patients experienced financial toxicity, with financial status, family dynamics, and widowhood being key influencing factors.  \nSubjects Nursing, Oncology, Women's Health  \nKeywords Gynecologic malignancy, Financial toxicity, Quality of life, Cross-sectional study, Correlation study  \nINTRODUCTION  \nGlobally, gynecological mali","cbCaioZgLflzayYq","https://ap.wps.com/l/cbCaioZgLflzayYq","pdf",232286,23,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the study’s primary aim?\",\"answer\":\"To assess the degree of financial toxicity among patients with gynecological cancers and evaluate its influence on quality of life, providing evidence for targeted clinical interventions.\"},{\"question\":\"How were participants and data collected?\",\"answer\":\"A convenience sampling approach recruited 281 patients from two hospitals in Nanjing. A cross-sectional survey was conducted between November 2022 and December 2024 using general information questionnaires, a financial toxicity comprehensive scale, and a cancer patient quality-of-life assessment scale.\"},{\"question\":\"What are the main findings about financial toxicity and quality of life?\",\"answer\":\"Most participants experienced financial toxicity, and the total financial toxicity score showed a significant positive correlation with quality of life (r = 0.553, P \\u003c 0.01). Core influencing factors included age of children, family per capita monthly income, recent treatment costs, and marital status.\"},{\"question\":\"Which factors were identified as key influences?\",\"answer\":\"Multivariate linear regression indicated that the age of children, family per capita monthly income, treatment costs in the past three months, and marital status were the core influencing factors.\"}]","Status of financial toxicity and its influence on quality of life in patients with gynecological malignancies in China - Research report | PDF",1790091661,58]