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This nationwide population-based cohort study examined whether statin prescription was associated with long-term all-cause mortality using Korean health insurance claims.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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were patients grouped in the study?","Question",{"text":62,"@type":63},"Patients were divided into four groups based on statin prescription duration: nonusers, T1, T2, and T3.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What measure was used to compare long-term survival among groups?",{"text":67,"@type":63},"Kaplan–Meier estimates and log-rank tests were used to compare survival across the four groups, and Cox proportional hazards models estimated hazard ratios for all-cause mortality.",{"name":69,"@type":60,"acceptedAnswer":70},"What was the main association between statin prescription duration and mortality?",{"text":71,"@type":63},"Across sexes, longer statin prescription duration showed lower all-cause mortality, with the lowest risk observed in T3 after full 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population-based cohort study (STROBE compliant)  \nJeongSook Kim, MSca , Yong-June Kim, MD, PhDb ,c , Da-Hye Son, MDd , Joungyoun Kim, PhDe , Jae-woo Lee, MD, PhDf , Hee-Taik Kang, MD, PhDg ,*  \n\n| Abstract\u003Cbr>Cancer survivorship is rapidly increasing in Korea, and long-term outcomes are influenced not only by cancer progression but also by competing risks such as cardio-cerebrovascular disease. Statins, routinely prescribed for cardiovascular prevention, have pleiotropic anti-inflammatory and immunomodulatory properties and have been suggested to affect outcomes in patients with cancer. We investigated whether statin prescription was associated with long-term all-cause mortality using data from Korean nationwide health insurance claims.Patients were divided into 4 groups based on the duration of statin prescription: nonusers, T1, T2, and T3 . Kaplan–Meier estimates and log-rank tests were performed to compare the survival rate among the 4 groups. Cox proportional hazards regression models were constructed for all-cause mortality. Among 154,916 patients, the median follow-up was 14.6 years, and the cumulative survival was lowest in statin nonusers and highest in T3 in both sexes (log-rank P \u003C .001) . After full adjustment, hazard ratios (95% confidence intervals) for all-cause mortality of T1, T2, and T3 were 0.637 (0 .619−0 .658), 0.482 (0 .462−0 .503), and 0.258 (0 .244−0 .272), respectively, in men and 0.608 (0 .580−0 .637), 0.406 (0 .385−0 .430), and 0.190 (0 . 178−0 .203), respectively, in women. Similar inverse associations were observed across most major cancer types. In this nationwide cohort of Korean cancer survivors, statin prescription duration was associated with lower all-cause mortality. Given the observational design and the potential for residual confounding and immortal time bias, these findings should be interpreted cautiously. - |\n| --- |\n| Abbreviations: ALT = alanine aminotransferase, BMI = body mass index, CCI = Charlson comorbidity index, CCVD = cardiocerebrovascular disease, HEALS = health screening cohort, ICD-10 = International Classification of Diseases, 10th edition, IRB = Instituitional Review Board, NHID = National Health Insurance Database, NHIS = National Health Insurance Service, SBP = systolic blood pressure. |\n| Keywords: cancer survivorship, hydroxymethylglutaryl-CoA reductase inhibitors, malignant, mortality, nationwide cohort, neoplasms |\n\nJSK, Y-JK, JK, and D-HS contributed to this article equally. The authors declare that they have no competing interests.  \nThe Institutional Review Board of Severance Hospital, Yonsei University Health System approved this study (IRB No. 4-2023-1272).  \nThe authors have no conflicts of interest to disclose.  \nThis research complied with the 1964 Helsinki Declaration. Informed consent was waived by the Institutional Review Board of Severance Hospital since this is a retrospective study.  \nThe data that support the findings of this study are available from the National Health Insurance Service (NHIS) of Korea; however, restrictions apply to the availability of these data, which were used under license for the current study and are not publicly available. Data are available from the NHIS through the Health Insurance Data Service upon reasonable request and with required approvals. This study was supported by a faculty research grant from Yonsei University College of Medicine (6-2023-0127). This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : RS‐2022‐KH129294).  \nSupplemental Digital Content is available in the online version of this article ([http://](http://)[ ](http://)[dx.doi.org/10.1097/MD.0000000000049171](dx.doi.org/10.1097/MD.0000000000049171)).  \na Department of Biost","cbCainZaKLYSRWpA","https://ap.wps.com/l/cbCainZaKLYSRWpA","pdf",1199934,"English","# Abstract\n## Study design and outcomes\n## Results and interpretation\n## Ethics and data availability","[{\"question\":\"How were patients grouped in the study?\",\"answer\":\"Patients were divided into four groups based on statin prescription duration: nonusers, T1, T2, and T3.\"},{\"question\":\"What measure was used to compare long-term survival among groups?\",\"answer\":\"Kaplan–Meier estimates and log-rank tests were used to compare survival across the four groups, and Cox proportional hazards models estimated hazard ratios for all-cause mortality.\"},{\"question\":\"What was the main association between statin prescription duration and mortality?\",\"answer\":\"Across sexes, longer statin prescription duration showed lower all-cause mortality, with the lowest risk observed in T3 after full adjustment.\"}]","Statin prescribing and long-term survival among Korean cancer survivors - A nationwide population-based cohort study (STROBE compliant) | PDF",1790110170,23]