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Altered expression of TC-related genes is discussed alongside potential drug-related effects (e.g., levothyroxine) and pandemic-related healthcare 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COVID-19—A Narrative Review  \nAgnieszka Bronowicka-Szydełko 1,†, Maciej Rabczy ´nski 2,†, Ilias Dumas 3, *, Z˙anna Fiodorenko-Dumas 3, Beata Wojtczak 4, Łukasz Kotyra 1, Irena Kustrzeba-Wójcicka 1, Łukasz Lewandowski 1, Beata Ponikowska 5, Aleksandra Kuzan 6, Joanna Kluz 2, Andrzej Gamian 7 and Katarzyna Madziarska 2  \nCitation: Bronowicka-Szydełko, A.; Rabczy ´nski, M.; Dumas, I.;  \nFiodorenko-Dumas, Z˙ .; Wojtczak, B.; Kotyra, Ł.; Kustrzeba-Wójcicka, I.; Lewandowski, Ł.; Ponikowska, B.; Kuzan, A.; et al. State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review. Biomedicines 2024, 12, 2829. [https://](https://)[ ](https://)[doi.org/10.3390/biomedicines12122829](doi.org/10.3390/biomedicines12122829)  \nAcademic Editor: Santiago Garcia-Vallve  \nReceived: 26 October 2024  \nRevised: 27 November 2024  \nAccepted: 6 December 2024  \nPublished: 13 December 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland; [agnieszka.bronowicka-szydelko@umw.edu.pl](agnieszka.bronowicka-szydelko@umw.edu.pl) (A.B.-S.); [kotyra.lukasz@gmail.com](kotyra.lukasz@gmail.com) (Ł.K.); [irena.kustrzeba-wojcicka@umw.edu.pl](irena.kustrzeba-wojcicka@umw.edu.pl) (I.K.-W.); [lukasz.lewandowski@umw.edu.pl](lukasz.lewandowski@umw.edu.pl) (Ł.L.)  \n2 Clinical Department of Diabetology, Hypertension and Internal Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland; [maciej.rabczynski@umw.edu.pl](maciej.rabczynski@umw.edu.pl) (M.R.); [joanna.kluz@umw.edu.pl](joanna.kluz@umw.edu.pl) (J.K.); [katarzyna.madziarska@umw.edu.pl](katarzyna.madziarska@umw.edu.pl) (K.M.)  \n3 Department of Clinical Physiotherapy and Rehabilitation, Wroclaw Medical University, 50-368 Wroclaw, Poland; [zanna.fiodorenko-dumas@umw.edu.pl](zanna.fiodorenko-dumas@umw.edu.pl)  \n4 University Center for General and Oncological Surgery, Wroclaw Medical University, 50-368 Wroclaw, Poland; [beata.wojtczak@umw.edu.pl](beata.wojtczak@umw.edu.pl)  \n5 Department of Physiology and Pathophysiology, Division of Physiology, Wroclaw Medical University, 50-368 Wroclaw, Poland; [beata.ponikowska@umw.edu.pl](beata.ponikowska@umw.edu.pl)  \n6 Department of Preclinical Sciences, Pharmacology and Medical Diagnostics, Wroclaw University of Science and Technology, 51-377 Wroclaw, Poland; [aleksandra.kuzan@pwr.edu.pl](aleksandra.kuzan@pwr.edu.pl)  \n7 Hirszfeld Institute of Immunology and Experimantal Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland; [andrzej.gamian@hirszfeld.pl](andrzej.gamian@hirszfeld.pl)  \n* Correspondence: [ilias.dumas@umw.edu.pl](ilias.dumas@umw.edu.pl)[ ](ilias.dumas@umw.edu.pl)† These authors contributed equally to this work.  \nAbstract: Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types of TC, which complicates diagnosis and treatment. The presented review gathers current information on specific types of TC, taking into account the effects of the COVID-19 pandemic. It is likely that COVID-19 has influenced and continues to influence the function of the thyroid gland. A high percentage of patients with COVID-19 showing simultaneous pathological changes in the thyroid suggests that SARS-CoV-2 may disrupt the function of this gland and initiate pro-oxidative mechanisms, inflammatory states, and autoimmune diseases, thereby promoting the formation of neoplastic changes. Furthermore, changes in the expression of the ACE2, TMPRSS2, CLEC4M and DPP4 genes, observed in TC, also occur in COVID-19 . Therefore,","cbCaieAm7k4GYyAi","https://ap.wps.com/l/cbCaieAm7k4GYyAi","pdf",1082534,26,"English","# Introduction\n## Thyroid cancer histological types\n# Abstract\n## COVID-19 impact mechanisms\n# Keywords","[{\"question\":\"Why is thyroid cancer considered a clinical challenge in the review?\",\"answer\":\"Thyroid cancer is described as heterogeneous, with many factors initiating carcinogenesis across different types, which complicates diagnosis and treatment.\"},{\"question\":\"What does the review suggest about the relationship between COVID-19 and thyroid cancer?\",\"answer\":\"The review suggests COVID-19 may influence thyroid gland function, with SARS-CoV-2 potentially disrupting it and promoting pro-oxidative, inflammatory, and autoimmune states that support neoplastic changes.\"},{\"question\":\"Which molecular and genetic factors does the review mention in linking thyroid cancer and COVID-19?\",\"answer\":\"It highlights changes in expression of ACE2, TMPRSS2, CLEC4M, and DPP4 genes that are observed in thyroid cancer and also occur in COVID-19, suggesting possible receptor-mediated interactions.\"}]","State of Knowledge About Thyroid Cancers in the Era of COVID-19 - A Narrative Review | PDF",1789994507,66]