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This matched controlled cohort study compared a standardized two-week thalassotherapy program with conventional rehabilitation in posttraumatic patients, using identical physiotherapy and hydrokinetic exercises plus daily seawater baths, sapropelic mud, and marine aerosols. Outcomes included pain, joint mobility, inflammatory status, quality of life, and monitoring of adverse events and tolerance. Thalassotherapy showed greater short-term improvement in function, pain, inflammatory balance, and quality of life. No adverse events were recorded, but non-randomization and short follow-up require cautious interpretation and further long-term randomized research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/standardized-thalassotherapy-versus-conventional-rehabilitation-in-post-traumatic-patients-clinical-biochemical-and-quality-of-life-outcomes/461117/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/standardized-thalassotherapy-versus-conventional-rehabilitation-in-post-traumatic-patients-clinical-biochemical-and-quality-of-life-outcomes/461117.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To evaluate the short-term clinical effects of a standardized two-week thalassotherapy program compared with conventional rehabilitation in posttraumatic patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the thalassotherapy group differ from conventional rehabilitation?",{"text":117,"@type":113},"Both groups followed identical physiotherapy and hydrokinetic exercise routines; the thalassotherapy group additionally received daily seawater baths, sapropelic mud applications, and exposure to marine aerosols.",{"name":119,"@type":110,"acceptedAnswer":120},"Which outcomes were measured before and after the intervention?",{"text":121,"@type":113},"Pain levels, joint mobility, inflammatory status, and quality of life, along with adverse events and treatment tolerance monitored throughout the study.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461117,1791024064,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Article  \nStandardized Thalassotherapy Versus Conventional Rehabilitation in Post-Traumatic Patients: Clinical, Biochemical, and Quality-of-Life Outcomes  \nMihaela Mihai 1,*, Nica Sarah Adriana 2, Brindusa Ilinca Mitoiu 2, Liliana Sachelarie 3, * and Roxana Nartea 2  \nAcademic Editor: Madeleine  \nE. Hackney  \nReceived: 26 October 2025  \nRevised: 27 November 2025  \nAccepted: 19 December 2025  \nPublished: 21 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Corpore Sano Sanatorium Techirghiol, Faculty of Medicine, University of Medicine and Pharmacy“Carol Davila”, 050474 Bucharest, Romania  \n2 Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania; [sarah.nica@umfcd.ro](sarah.nica@umfcd.ro) (N.S.A.); roxana.nartea@umfcd.ro (R.N.)  \n3 Preclinical Sciences Department, Faculty of Medicine, Apollonia University, 700511 Iasi, Romania  \n* Correspondence: roxana-mihaela.bianu@drd.umfcd.ro (M.M.); [lisachero@yahoo.com](lisachero@yahoo.com) (L.S.)  \nAbstract  \nBackground: Thalassotherapy, which combines seawater, marine mud, and maritime climate, has been traditionally used to support musculoskeletal recovery. Its thermal, biochemical, and mechanical properties may enhance tissue healing and modulate inflammation. This study aimed to evaluate the short-term clinical effects of a standardized two-week thalassotherapy program compared with conventional rehabilitation in posttraumatic patients. Methods: A matched controlled cohort study was conducted at the Corpore Sano Sanatorium, Techirghiol, Romania. Post-traumatic patients followed identical physiotherapy and hydrokinetic exercise routines; additionally, the thalassotherapy group received daily seawater baths, sapropelic mud applications, and exposure to marine aerosols. Pain levels, joint mobility, inflammatory status, and quality of life were assessed before and after the intervention. Adverse events and treatment tolerance were monitored throughout the study. Results: Patients undergoing thalassotherapy experienced more pronounced improvements in musculoskeletal function, pain relief, inflammatory balance, and quality-of-life outcomes compared with those receiving standard rehabilitation alone. Both interventions contributed to clinical progress, but the magnitude of change was consistently greater among patients treated with marine-based therapies. No adverse events or intolerance reactions were recorded, and all participants completed the program. Conclusions: Thalassotherapy may provide complementary short-term benefits in post-traumatic rehabilitation, enhancing functional recovery, symptom relief, and perceived well-being. However, due to the non-randomized design and short follow-up period, these findings should be interpreted cautiously. Further randomized studies with long-term outcomes are required to confirm the therapeutic role of thalassotherapy in modern rehabilitation practice.  \nKeywords: inflammation; marine mud; post-traumatic recovery; quality of life; rehabilitation; thalassotherapy  \n1. Introduction  \nThalassotherapy, defined as the therapeutic use of seawater, marine mud, algae, and the maritime climate, has a long tradition in medicine, being practiced for centuries in coastal regions to restore health and well-being [1] . In recent decades, its relevance has been  \nreinforced by an increasing number of clinical and experimental studies that emphasize its multifactorial benefits, ranging from musculoskeletal recovery to improvements in metabolic and cardiovascular balance, as well as psychological well-being [2] . This broad applicability has positioned thalassotherapy as a complementary approach within modern rehabilitation medicine, bridging traditional natural therapies with contemporary evidencebased practices.  \nThe therapeutic effects of thal","cbCaifYYr3YjUPs9","https://ap.wps.com/l/cbCaifYYr3YjUPs9","pdf",507407,13,"English","# Abstract\n# Introduction\n## Background and rationale for thalassotherapy\n## Biological mechanisms: seawater minerals and aerosols\n## Biological mechanisms: marine muds, algae, and climate effects\n# Methods\n## Study design and intervention\n## Outcome assessment and safety monitoring\n# Results\n## Clinical and biochemical improvements\n## Adverse events and treatment tolerance\n# Conclusions\n## Summary of benefits and study limitations","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To evaluate the short-term clinical effects of a standardized two-week thalassotherapy program compared with conventional rehabilitation in posttraumatic patients.\"},{\"question\":\"How did the thalassotherapy group differ from conventional rehabilitation?\",\"answer\":\"Both groups followed identical physiotherapy and hydrokinetic exercise routines; the thalassotherapy group additionally received daily seawater baths, sapropelic mud applications, and exposure to marine aerosols.\"},{\"question\":\"Which outcomes were measured before and after the intervention?\",\"answer\":\"Pain levels, joint mobility, inflammatory status, and quality of life, along with adverse events and treatment tolerance monitored throughout the study.\"}]","Standardized Thalassotherapy Versus Conventional Rehabilitation in Post-Traumatic Patients - Clinical, Biochemical, and Quality-of-Life Outcomes | PDF",1790760669,33]