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The formulation combines a gum blend with an electrolyte-tolerant polymer to improve physical stability of emulsions containing clay and silicone oil, enabling application to skin via wipes. The disclosure addresses limitations of prior silicone-oil emulsions, including high emulsifier cost, difficulty achieving low-viscosity sprayable solutions, and phase separation after freeze-thaw 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condition is the stable emulsion intended to prevent?","Question",{"text":113,"@type":114},"The disclosure focuses on preventing rash, particularly diaper rash, by protecting skin from irritation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which ingredients are central to the emulsion formulation?",{"text":118,"@type":114},"The emulsion includes a gum blend and an electrolyte tolerant polymer, and it is designed to work with clay and silicone oil.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are previous silicone-oil emulsion approaches considered insufficient?",{"text":122,"@type":114},"They may require costly emulsifiers, can be hard to make low-viscosity and sprayable, and may undergo phase separation, especially after freeze-thaw 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publication and mention of the grant of the patent:  \n21.12.2016 Bulletin 2016/51  \n(21) Application number: 13809933.8  \n(22) Date of filing: 26.06.2013  \n(51) Int Cl.:  \nA61K 8/60 (2006.01)  \nA61K 8/19 (2006.01)  \nA61K 8/891 (2006.01) A61K 8/02 (2006.01)  \nA61Q 19/00 (2006.01)  \n(86) International application number:  \nPCT/IB2013/055260  \n(87) International publication number:  \nWO 2014/002037 (03.01.2014 Gazette 2014/01)  \n\n| (54) STABLE EMULSION FOR PREVENTION OF SKIN IRRITATION AND ARTICLES USING SAME STABILE EMULSION ZUR PRÄVENTION VON HAUTIRRITATIONEN UND ARTIKEL DAMIT EMULSION STABLE POUR LA PRÉVENTION DE L’IRRITATION DE LA PEAU ET ARTICLES FABRIQUÉS À SON AIDE |  |  |\n| --- | --- | --- |\n| (84) Designated Contracting States:\u003Cbr>AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NOPL PT RO RS SE SI SK SM TR\u003Cbr>(30) Priority: 29.06.2012 US 201261666407 P\u003Cbr>24.06.2013 US 201313925788\u003Cbr>(43) Date of publication of application:\u003Cbr>06.05.2015 Bulletin 2015/19\u003Cbr>(73) Proprietor: Kimberly-Clark Worldwide, Inc.\u003Cbr>Neenah, Wisconsin 54956 (US)\u003Cbr>(72) Inventors:\u003Cbr>• CUNNINGHAM, Corey, Thomas Larsen, Wisconsin 54947 (US) | • SEIDLING, Jeffery, Richard Appleton, Wisconsin 54915 (US)\u003Cbr>• KROLL, Lisa, Marie Appleton, Wisconsin 54911 (US)\u003Cbr>• MUNDSCHAU, Stacy, Averic Weyauwega, Wisconsin 54983 (US)\u003Cbr>(74) Representative: Beacham, Annabel Rose Dehns\u003Cbr>St Bride’s House\u003Cbr>10 Salisbury Square\u003Cbr>London EC4Y 8JD (GB) |  |\n|  | (56) References cited:\u003Cbr>EP-A1-2 314 350 US-A1-2009 035 229 US-B2-7 651 691 | US-A-5 985 177 US-A1-2011 033 413 US-B2-7 838 477 |\n| Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention) . |  |  |\n\nPrinted by Jouve, 75001 PARIS (FR)  \n5  \n10  \n15  \n20  \n25  \n30  \n35  \n40  \n45  \n50  \n55  \nEP 2 866 784 B1  \nDescription  \n[0001] This application claims priority as a continuation of Application No. 61/666407, filed on June 29, 2012. The entirety of Application No. 61/666407 is incorporated herein by reference.  \nBACKGROUND OF THE DISCLOSURE  \n[0002] The present disclosure relates generally to a formulation in the form of an emulsion which includes a combination of a gum blend and an electrolyte tolerant polymer, and items using same. The gum blend provides physical stability to an emulsion containing both clay and silicone oil. The emulsion of the present disclosure is useful for rash prevention and may be applied to the skin with a wipe wetted therewith or by other various means.  \n[0003] Wet wipes have been used for years for convenient skin cleansing between diaper changes. Much headway has been made in creating formulations for wet wipes. Such formulations are in the form of emulsions which provide a vehicle for the application of active ingredients to the skin. These ingredients may be used to treat and/or prevent diaper rash.  \n[0004] Diaper rash is a form of contact dermatitis which afflicts infants or incontinent persons whose wet and/or soiled absorbent garments are not promptly changed. Because of the practical impossibility of attending promptly to all of a person’s needs, even those receiving a high level of care sometimes suffer from diaper rash. It has recently come to be understood that the initial stages of some types of diaper rash are the result of skin irritation caused by contact with digestive enzymes present in feces, particularly trypsin, chymotrypsin and elastase. These enzymes are proteolytic enzymes produced in the gastrointestinal tract to digest food. Similar conditions conducive to skin irr","cbCaiah16rkWGlVa","https://ap.wps.com/l/cbCaiah16rkWGlVa","pdf",239050,"English","# Background of the disclosure\n## Problem of diaper rash and skin irritation enzymes\n## Limits of existing stable silicone-oil emulsions\n## Need for an improved stable emulsion","[{\"question\":\"What condition is the stable emulsion intended to prevent?\",\"answer\":\"The disclosure focuses on preventing rash, particularly diaper rash, by protecting skin from irritation.\"},{\"question\":\"Which ingredients are central to the emulsion formulation?\",\"answer\":\"The emulsion includes a gum blend and an electrolyte tolerant polymer, and it is designed to work with clay and silicone oil.\"},{\"question\":\"Why are previous silicone-oil emulsion approaches considered insufficient?\",\"answer\":\"They may require costly emulsifiers, can be hard to make low-viscosity and sprayable, and may undergo phase separation, especially after freeze-thaw cycles.\"}]","Stable Emulsion for Prevention of Skin Irritation - Stable Emulsion zur Prävention von Hautirritationen | PDF",1790145583,48]