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Bioinformatics analysis using the GEO database evaluates EGFR–SSTR2 correlation, and immunohistochemistry measures SSTR2 and EGFR in 491 NPC cases and 50 non-cancerous nasopharyngeal epithelium samples. Results show a positive SSTR2–EGFR correlation in NPC, with high expression linked to worse progression-free and overall survival, especially under chemoradiotherapy (CR). Cox multivariate analysis identifies SSTR2 and EGFR as independent poor predictors of PFS, while targeted therapy combined with CR may improve prognosis in selected high-expression groups. The work proposes SSTR2 as a potential biomarker for poor outcomes and provides insight into potential benefits of EGFR-targeted therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sstr2-positively-associates-with-egfr-and-predicts-poor-prognosis-in-nasopharyngeal-carcinoma-abstract/329708/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sstr2-positively-associates-with-egfr-and-predicts-poor-prognosis-in-nasopharyngeal-carcinoma-abstract/329708.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study aim to determine about SSTR2 and EGFR in NPC?","Question",{"text":112,"@type":113},"The study investigates whether SSTR2 is associated with EGFR and with clinicopathological features in nasopharyngeal carcinoma, and how these markers relate to prognosis and treatment response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were EGFR and SSTR2 evaluated in the study?",{"text":117,"@type":113},"Correlation was assessed via bioinformatics using the GEO database, and SSTR2 and EGFR expression were measured by immunohistochemistry in 491 NPC cases and 50 non-cancerous nasopharyngeal epithelium samples.",{"name":119,"@type":110,"acceptedAnswer":120},"What prognostic impact does high SSTR2 and/or EGFR expression have in NPC patients?",{"text":121,"@type":113},"High expression of SSTR2 and/or EGFR is associated with worse outcomes and higher progression risk. Under chemoradiotherapy, patients with high SSTR2 and high EGFR (or their coexpression) showed poorer progression-free and overall survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329708,1790465604,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Original research  \nSSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma  \nYue Xu  , 1 Zihan Quan, 1 Yuting Zhan, 1 Haihua Wang, 1 Jiadi Luo, 1 Weiyuan Wang,2 Songqing Fan 1  \n► Additional supplemental material is published online only. To view, please visit the journal online ([http://dx](http://dx). [doi.org/10.1136/jcp-2023-](doi.org/10.1136/jcp-2023-)[ ](doi.org/10.1136/jcp-2023-)[208987](208987)) .  \n1Pathology, The Second Xiangya Hospital of Central South University, Changsha, China 2Pathology, Xiangya Hospital of Central South University, Changsha, China  \nCorrespondence to  \nProfessor Songqing Fan, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; [songqi](songqingfan@csu.edu.cn)[ngfan@csu.edu.cn](songqingfan@csu.edu.cn)  \nReceived 29 May 2023 Accepted 1 September 2023  \n© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \nTo cite: Xu Y, Quan Z, Zhan Y, et al. J Clin Pathol Epub ahead of print: [please include Day Month Year] . doi:10 . 1136/jcp-2023- 208987  \nABSTRACT  \nAims Epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases family andoverexpression of EGFR has been linked to poor prognosis and cancer progression. Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions in humans, and it is upregulated through the NF-KB signalling pathway innasopharyngeal carcinomas (NPC) . However, no studies have examined the EGFR and SSTR2 in NPC. This study aimed to investigate whether SSTR2 is associated with EGFR and clinicopathological features in NPC.  \nMethods Bioinformatics analysis was performed to assess the correlation between EGFR and SSTR2 based on the GEO database. The expression of SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous nasopharyngeal epithelium.  \nResults The bioinformatics analysis and IHC showed a positive correlation between SSTR2 and EGFR in NPC. High expression of SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous nasopharyngeal epithelium. High expression of SSTR2 and/or EGFR was associated with a worse outcome and a higher risk of progression. The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis in both progression-free survival (PFS) and overall survival (OS). Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression of EGFR and SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis with CR combined with targeted therapy. Cox multivariate analysis identified SSTR2 and EGFR as independent poor predictors of PFS.  \nConclusion Our study is the first to shed light on the intricate relationship between SSTR2 and EGFR in NPC and provides new insights into the potential benefits of EGFR targeted therapy for patients with high SSTR2 expression. Additionally, SSTR2 has potential as a new biomarker for poor prognosis in NPC patients.  \nINTRODUCTION  \nNasopharyngeal carcinoma (NPC) is an epithelial cancer that occurs in the mucosa lining of the nasopharynx. This cancer is caused by a combination of factors, with the most significant being infection with Epstein-Barr virus (EBV). Persistently elevated EBV antibody levels are considered a major risk factor for NPC.1–3 NPC is a regional cancer, with high incidence rates in southern China  \nWHAT IS ALREADY KNOWN ON THIS TOPIC  \n\n| ⇒ Recent studies have highlighted the effectiveness of epidermal growth\u003Cbr>factor receptor (EGFR)-targeted drugs innasopharyngeal carcinomas (NPC), yet drug resistance has emerged as a challenge. SSTR2, highly expressed in NPC, is considered a potential tumour marker and therapeutic target.\u003Cbr>WHAT THIS STUDY ADDS |\n|","cbCaiagAlvRok9yh","https://ap.wps.com/l/cbCaiagAlvRok9yh","pdf",1789298,"English","# Abstract\n# Introduction\n# What is already known on this topic\n## Recent studies\n# What this study adds\n## Protein-level correlation and prognostic value\n# How this study might affect research, practice or policy\n## Personalized therapy implications","[{\"question\":\"What does the study aim to determine about SSTR2 and EGFR in NPC?\",\"answer\":\"The study investigates whether SSTR2 is associated with EGFR and with clinicopathological features in nasopharyngeal carcinoma, and how these markers relate to prognosis and treatment response.\"},{\"question\":\"How were EGFR and SSTR2 evaluated in the study?\",\"answer\":\"Correlation was assessed via bioinformatics using the GEO database, and SSTR2 and EGFR expression were measured by immunohistochemistry in 491 NPC cases and 50 non-cancerous nasopharyngeal epithelium samples.\"},{\"question\":\"What prognostic impact does high SSTR2 and/or EGFR expression have in NPC patients?\",\"answer\":\"High expression of SSTR2 and/or EGFR is associated with worse outcomes and higher progression risk. Under chemoradiotherapy, patients with high SSTR2 and high EGFR (or their coexpression) showed poorer progression-free and overall survival.\"}]","SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma - abstract | PDF",1789985273,15]