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Parents sought pediatric urologic care for an eight-year-old with a growth beside the external urethral meatus. Surgical removal of a necrotic exophytic 3 cm lesion was followed by cystoscopy and vaginoscopy, with normal cystoscopic findings but multiple papillomatous cervix and vaginal wall lesions. Biopsies confirmed a fibroepithelial polyp with squamous epithelium and vaginal squamous papillomatosis, and vaginoscopy in the twin revealed small solitary vaginal papillomas, suggesting inheritance and shared bacterial/viral exposure.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/squamous-vaginal-papillomatosis-in-prepubertal-female-twins-a-case-report/208909/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/squamous-vaginal-papillomatosis-in-prepubertal-female-twins-a-case-report/208909.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-05",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition is described in the twins?","Question",{"text":113,"@type":114},"The case describes vaginal papillomatosis in prepubertal female twins, including a vulvar fibroepithelial polyp in one twin and vaginal squamous papillomatosis. The twin sister also shows small solitary vaginal papillomas.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the diagnosis investigated for the first twin?",{"text":118,"@type":114},"After informed consent, the exophytic necrotic structure was removed and cystoscopy and vaginoscopy were performed. Vaginal biopsy samples were taken from areas affected by papillomatosis for histopathologic examination.",{"name":120,"@type":111,"acceptedAnswer":121},"What did cystoscopy show and what was found on vaginoscopy?",{"text":122,"@type":114},"Cystoscopy findings were normal. Vaginoscopy identified numerous macroscopic papillomatous structures on the cervix and vaginal walls.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},208909,1788607152,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":144},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Contents lists available at Vilnius University Press  \n\n| Acta medica Lituanica\u003Cbr>2021. Online ahead of print | ISSN 1392-0138 eISSN 2029-4174 DOI: [https://doi.org/10.15388/Amed.2021.28.2.18](https://doi.org/10.15388/Amed.2021.28.2.18) |\n| --- | --- |\n| Squamous Vaginal Papillomatosis in Prepubertal Female Twins: A Case Report\u003Cbr>Evelina Boreikaitė*\u003Cbr>Clinic of Obstetrics and Gynecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius University Hospital Santaros klinikos, Vilnius, Lithuania\u003Cbr>Vytautas Bilius\u003Cbr>Clinic of Children Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius University Hospital Santaros klinikos, Vilnius, Lithuania\u003Cbr>Elžbieta Bumbul-Mazurek\u003Cbr>1st Department of Obstetrics and Gynecology Medical University of Warsaw, Warsaw, Poland\u003Cbr>Žana Bumbulienė\u003Cbr>Clinic of Obstetrics and Gynecology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius University Hospital Santaros klinikos, Vilnius, Lithuania |  |\n\nAbstract. This is the first case describing vaginal papillomatosis with a fibroepithelial polyp of the vulva in aprepubertal girl and vaginal papillomatosis in her twin sister. Parents contacted pediatric urologist regarding their eight-year-old daughter (twin A), who had a growth next to the external urethral meatus. The girl was referred to a pediatric surgeon. The exophytic 3 cm long structure with necrosis on top was found. After obtaining informed consent from girl parents, pediatric surgeon removed the exophytic structure and perform cystoscopy and vaginoscopy for possible changes in the bladder and vagina. Cystoscopy findings were normal. On vaginoscopy, numerous macroscopic papillomatous structures were identified on the cervix and vaginal walls. Vaginal biopsies were performed on the areas affected by papillomatosis. Histopathologic examination showed a fibroepithelial polyp with a central fibrovascular core covered by squamous epithelium and vaginal squamous papillomatosis. The decision was made to perform vaginoscopy on her twin sister (twin B), too. On vaginoscopy, solitary small vaginal papillomas were also found. In this case manifestation of vaginal papillomatosis in twins might have been influenced by inheritance and the same bacterial and viral environment.  \nKey-words: vaginal papillomatosis, vulvar fibroepithelial polyp, female twins, prepubertal girls  \nMakšties plokščialąstelinės papilomos dvynėms iki lytinio brendimo: klinikinis atvejis  \nSantrauka. Tai pirmasis klinikinis atvejis, kuriame aprašomos makšties plokščialąstelinės papilomos, diagnozuotos dvynėms iki lytinio brendimo, taip pat fibroepitelinis polipas nustatytas vienai iš dvynių . Tėvai  \n* Corresponding author: Evelina Boreikaitė, Vilnius University, Vilnius University Hospital Santaros klinikos, Clinic of Obstetrics and  \nGynaecology, Santariskiu st. 2, LT-08661, Vilnius, Lithuania. E-mail: [evelina.boreikaite@gmail.com](evelina.boreikaite@gmail.com)  \nReceived: 06/07/2021 . Revised: 01/10/2021 . Accepted: 20/10/2021  \nCopyright © 2021 Evelina Boreikaitė, Vytautas Bilius, Elžbieta Bumbul-Mazurek, Žana Bumbulienė . Published by Vilnius University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nEvelina Boreikaitė et al. Squamous Vaginal Papillomatosis in Prepubertal Female Twins: A Case Report  \nkreipėsi į vaikų urologą dėl aštuonerių metų dukters (dvynės A), kuriai pastebėjo darinį šalia išorinės šlaplėsangos. Mergaitė buvo nukreipta vaikų chirurgo konsultacijai. Nustatyta egzofitinė 3 cm struktūra su nekroze viršutinėje dalyje. Gavus informuotą mergaičių tėvų sutikimą, vaikų chirurgas pašalino egzofitinę struktūrą ir atliko cistoskopiją bei vaginoskopiją dėl galimų šlapimo pūslės ir makšties pakitimų . Cistoskopijos metupato","cbCaik4psMFdJVoz","https://ap.wps.com/l/cbCaik4psMFdJVoz","pdf",2009915,"English","# Abstract\n# Introduction\n# Case report","[{\"question\":\"What condition is described in the twins?\",\"answer\":\"The case describes vaginal papillomatosis in prepubertal female twins, including a vulvar fibroepithelial polyp in one twin and vaginal squamous papillomatosis. The twin sister also shows small solitary vaginal papillomas.\"},{\"question\":\"How was the diagnosis investigated for the first twin?\",\"answer\":\"After informed consent, the exophytic necrotic structure was removed and cystoscopy and vaginoscopy were performed. Vaginal biopsy samples were taken from areas affected by papillomatosis for histopathologic examination.\"},{\"question\":\"What did cystoscopy show and what was found on vaginoscopy?\",\"answer\":\"Cystoscopy findings were normal. Vaginoscopy identified numerous macroscopic papillomatous structures on the cervix and vaginal walls.\"}]","Squamous Vaginal Papillomatosis in Prepubertal Female Twins - A Case Report | PDF",13]