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Results showed significantly higher mRNA and protein levels of SQSTM1/p62 in tumors than in normal tissues across cancer types. High SQSTM1/p62 expression associated with poorer overall survival and disease-specific survival. In 86 NPC patients, high expression independently predicted reduced DSS, and relationships remained stable in unadjusted and multivariable-adjusted models without significant interactions by age, TNM stage, or treatment strategy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/sqstm1p62-as-a-prognostic-indicator-in-pancancer-and-nasopharyngeal-carcinoma/369902/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/sqstm1p62-as-a-prognostic-indicator-in-pancancer-and-nasopharyngeal-carcinoma/369902.png","ImageObject",300,407,{"name":92,"@type":93},"Bulrr","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate regarding SQSTM1/p62 in cancers and NPC?","Question",{"text":112,"@type":113},"The study evaluates SQSTM1/p62 expression patterns and their prognostic value across multiple cancers, with a specific focus on nasopharyngeal carcinoma (NPC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is SQSTM1/p62 expression associated with outcomes?",{"text":117,"@type":113},"Higher SQSTM1/p62 expression correlates with poorer overall survival and disease-specific survival across multiple cancers, and independently predicts reduced disease-specific survival in NPC.",{"name":119,"@type":110,"acceptedAnswer":120},"Does SQSTM1/p62 prognostic value vary with clinical factors or treatment methods?",{"text":121,"@type":113},"No significant interaction was observed between SQSTM1/p62 expression and age, TNM stage, or treatment methods such as induction chemotherapy, concurrent chemoradiotherapy, and adjuvant chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},369902,1790262495,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},5909892115043,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Chen et al. BMC Research Notes (2025) 18:421 [https://doi.org/10.1186/s13104-025-07464-0](https://doi.org/10.1186/s13104-025-07464-0)  \nBMC Research Notes  \nRESEARCH NOTE Open Access  \nSQSTM1/p62 as a prognostic indicator  in pancancer and nasopharyngeal carcinoma  \nLi-li Chen 1†, Zong-yao Zhang3†, Bo Wu4* and Mei-zhen Lu2*  \nAbstract  \nObjective This study evaluated SQSTM1/p62 expression patterns and its prognostic value across multiple cancers, with a focus on nasopharyngeal carcinoma (NPC) .  \nResults description SQSTM1/p62 showed significantly higher mRNA and protein levels in tumors versus normal tissues across cancer types. High SQSTM1/p62 expression correlated with poorer OS and DSS in multiple cancers. Among 86 NPC patients (median follow-up 46.8 months), high SQSTM1/p62 expression (69 . 8% vs CNP 45% in controls, P = 0 . 036) independently predicted reduced DSS (HR = 4 . 51, 95% CI: 1.40–14. 52) . The unadjusted and multivariable-adjusted models consistently revealed a stable relationship between SQSTM1/p62 expression and patient prognosis. No significant interaction was observed between SQSTM1/p62 expression and age, TNM stage, or treatment methods (induction chemotherapy, concurrent chemoradiotherapy, adjuvant chemotherapy) . In summary, elevated SQSTM1/p62 expression correlates with poor clinical outcomes in pancancer analyses and serves as an independent prognostic factor for NPC.  \nKeywords Nasopharyngeal carcinoma, SQSTM1/p62, Prognostic indicator, Pancancer analysis, Autophagy  \n†Li-li Chen and Zong-yao Zhang have contributed equally to this work.  \n*Correspondence: Bo Wu [chinawb2006@163.com](chinawb2006@163.com)[ ](chinawb2006@163.com)[Mei-zhen Lu](Mei-zhen Lu)[lmzxm6@163.com](lmzxm6@163.com)  \n1Department of Pathology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China  \n2Department of Health Medicine, Zhongshan Hospital Xiamen University, Xiamen, China  \n3Department of General Surgery, The First Hospital of Anhui University of Science and Technology, Huainan, Anhui, China  \n4Health College, Binzhou Polytechnic, Binzhou, Shandong, China  \nIntroduction  \nNasopharyngeal carcinoma (NPC) is a distinct malignancy with a high prevalence in Southeast Asia, particularly in southern China [1]. It poses significant clinical challenges due to its aggressive behavior and frequent late-stage diagnosis in affected patients. Despite advances in imaging techniques and therapeutic modalities, including intensity-modulated radiotherapy and combined chemotherapy, the prognosis of patients with NPC remains poor [2]. Distant metastases and treatment resistance drive mortality [3, 4]. Consequently, there isan urgent need to identify reliable biomarkers and therapeutic targets to improve early diagnosis and guide personalized treatment, potentially providing personalized approaches for managing NPC.  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nChen et al. BMC Research Notes (2025) ","cbCaisxTQ70f65Oh","https://ap.wps.com/l/cbCaisxTQ70f65Oh","pdf",2828681,12,"English","# Abstract\n## Objective and Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and methods\n## Gene expression and prognosis analysis","[{\"question\":\"What does the study evaluate regarding SQSTM1/p62 in cancers and NPC?\",\"answer\":\"The study evaluates SQSTM1/p62 expression patterns and their prognostic value across multiple cancers, with a specific focus on nasopharyngeal carcinoma (NPC).\"},{\"question\":\"How is SQSTM1/p62 expression associated with outcomes?\",\"answer\":\"Higher SQSTM1/p62 expression correlates with poorer overall survival and disease-specific survival across multiple cancers, and independently predicts reduced disease-specific survival in NPC.\"},{\"question\":\"Does SQSTM1/p62 prognostic value vary with clinical factors or treatment methods?\",\"answer\":\"No significant interaction was observed between SQSTM1/p62 expression and age, TNM stage, or treatment methods such as induction chemotherapy, concurrent chemoradiotherapy, and adjuvant chemotherapy.\"}]","SQSTM1/p62 as a prognostic indicator in pancancer and nasopharyngeal carcinoma | PDF",1790185159]