[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331037-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-331037-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","spop-expression-is-associated-with-tumor-infiltrating-lymphocytes-in-pancreatic-cancer","SPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer","","Speckle Type POZ Protein (SPOP) functions in a tumor-type dependent manner, but its role in pancreatic cancer and its link to immune responses remain unclear. This study evaluates SPOP expression and its association with prognosis and immune function using TCGA, GTEx, TIMER2.0, cBioportal, and bioinformatic analyses. Enrichment analyses and R-based correlations were complemented by immunohistochemistry to assess tumor-infiltrating lymphocytes (TILs).",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/spop-expression-is-associated-with-tumor-infiltrating-lymphocytes-in-pancreatic-cancer/331037/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/spop-expression-is-associated-with-tumor-infiltrating-lymphocytes-in-pancreatic-cancer/331037.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main focus of the study on SPOP in pancreatic cancer?","Question",{"text":63,"@type":64},"The study investigates how SPOP expression relates to patient prognosis and immune function, with particular attention to tumor-infiltrating lymphocytes in pancreatic cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which datasets and bioinformatic tools were used to assess SPOP expression?",{"text":68,"@type":64},"SPOP expression and immune associations were evaluated using TCGA, GTEx, TIMER2.0, cBioportal, GEPIA, and related enrichment analyses.",{"name":70,"@type":61,"acceptedAnswer":71},"How were tumor-infiltrating lymphocytes (TILs) evaluated in patients?",{"text":72,"@type":64},"Immunohistochemistry (IHC) was used to estimate the correlation between SPOP and tumor-infiltrating lymphocytes in pancreatic cancer patients.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331037,1790143688,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":117,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":104,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","PLOS ONE  \nOPEN ACCESS  \nCitation: Yang XJ, Xu YF, Zhu Q (2024) SPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer. PLoS ONE 19(7): e0306994 . [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0306994  \nEditor: Giovanni Messina, University of Rome, ITALY  \nReceived: December 9, 2023  \nAccepted: June 26, 2024  \nPublished: July 29, 2024  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:  \n[https://doi.org/10.1371/journal.pone.0306994](https://doi.org/10.1371/journal.pone.0306994)  \n[Copyright:](Copyright:) © [2024 Yang](2024 Yang) et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the paper and its Supporting Information files.  \nFunding: The author(s) received no specific funding for this work.  \nRESEARCH ARTICLE  \nSPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer  \nXiao Juan Yang‡, Yong Feng Xu‡, Qing Zhu *  \nAbdominal Oncology Ward, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, P. R. China  \n‡ XJY and YFX should be considered joint first author.  \n* [newzhuqing1972@yahoo.com](newzhuqing1972@yahoo.com)  \nAbstract  \nBackground  \nSpeckle Type POZ Protein (SPOP), despite its tumor type-dependent role in tumorigenesis, primarily as a tumor suppressor gene is associated with a variety of different cancers. However, its function in pancreatic cancer remains uncertain.  \nMethods  \nSPOP expression and the association between its expression and patient prognosis and immune function were evaluated using The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), The Tumor Immune Estimation Resource 2.0 (TIMER2 .0) database, cBioportal, and various bioinformatic databases. Enrichment analysis of SPOP and the association between SPOP expression with clinical stage and grade were analyzed using the R software package. Then immunohistochemistry (IHC) was used to estimate the correlation between SPOP and tumor-infiltrating lymphocytes (TILs) in patients with pancreatic cancer.  \nResults  \nAs part of our study, we assessed that SPOP was anomalously expressed in kinds of cancers, associated with clinical stage and outcomes. Meanwhile, SPOP also played a crucial role in the tumor microenvironment (TME) . The expression level of SPOP was significantly correlated to tumor-infiltrating immune cells (TICs) in pancreatic cancer.  \nConclusions  \nOur study uncovered the potential corrections in SPOP with TICs, suggesting that SPOP may act as a biomarker for immunotherapy in pancreatic cancer.  \nCompeting interests: The authors have declared that no competing interests exist.  \n1 Introduction  \nCell neoplastic transformation is a multi-step process which includes the acquisition of some certain characteristics and these characteristics confers a survival advantage in their microenvironment [ 1] . These traits, coined as the hallmarks of cancer, are acquired as neoplastic cells evolve and enable them to be tumorigenic and malignant [2] . Tumor microenvironmental (TME) has been reported as a critical trigger to promote tumor progression, associated with aggression, metastasis, and recrudescence [3–5] . However, with the constant progress and development of public repositories in recent years, such as The Tumor Immune Estimation Resource 2.0 (TIMER2 .0) dataset [6], it is possible to analysis pan-cancer genes and evaluate corrections in these genes with clinicopathologic prognosis and TME.  \nSpeckle Type POZ Protein (SPOP), a well-known E3 ubiquiti","cbCaihZWyxvR6DZa","https://ap.wps.com/l/cbCaihZWyxvR6DZa","pdf",5460094,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n# Methods\n## RNA-sequencing data and bioinformatic analysis","[{\"question\":\"What is the main focus of the study on SPOP in pancreatic cancer?\",\"answer\":\"The study investigates how SPOP expression relates to patient prognosis and immune function, with particular attention to tumor-infiltrating lymphocytes in pancreatic cancer.\"},{\"question\":\"Which datasets and bioinformatic tools were used to assess SPOP expression?\",\"answer\":\"SPOP expression and immune associations were evaluated using TCGA, GTEx, TIMER2.0, cBioportal, GEPIA, and related enrichment analyses.\"},{\"question\":\"How were tumor-infiltrating lymphocytes (TILs) evaluated in patients?\",\"answer\":\"Immunohistochemistry (IHC) was used to estimate the correlation between SPOP and tumor-infiltrating lymphocytes in pancreatic cancer patients.\"}]","SPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer | PDF",1789991288]