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This brief report surveys women in the Mayo Clinic SCAD “Virtual” Multi-Center Registry to quantify menopause symptoms and examine patterns of systemic versus local MHT use among 661 participants. Results show substantial symptom prevalence and relatively limited systemic MHT adoption, with differences in daily symptom reporting between MHT users and non-users.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/spontaneous-coronary-artery-dissection-menopausal-symptoms-and-hormone-therapy-use-in-661-women/441900/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/spontaneous-coronary-artery-dissection-menopausal-symptoms-and-hormone-therapy-use-in-661-women/441900.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s main objective regarding SCAD and menopause?","Question",{"text":113,"@type":114},"To quantify the burden of menopause symptoms in women with a history of SCAD and to examine patterns of menopause hormone therapy (MHT) use.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were participants recruited and how many were included in the analysis?",{"text":118,"@type":114},"Participants came from the Mayo Clinic SCAD “Virtual” Multi-Center Registry; 841 women completed key supplemental survey components, and the patient cohort analyzed included 661 women.",{"name":120,"@type":111,"acceptedAnswer":121},"What proportion of women used systemic or local MHT in the survey?",{"text":122,"@type":114},"Systemic MHT was used by 48 women (7.3%), while local therapy (e.g., low-dose topical vaginal estrogen) was used by 76 women (11.5%); overall, 110 women (16.6%) used MHT either systemically or locally.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},441900,1790736480,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52,"preview_page_count":4},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J A C C : A D V A N C E S V O L . 5 , N O . 1 , 2 0 2 6  \n© 2 0 2 6 T H E A U T H O R S . P U B L I S H E D BY E L S E V I E R O N B E H A L F O F T H E A M E R I C A N  \nC O L L E G E O F C A R D I O L O GY F O U N D A T I O N . T H I S I S A N O P E N A C C E S S A R T I C L E U N D E RT H E C C B Y-N C-N D L I C E N S E ( [h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y-n c-n d / 4 . 0 /](h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y-n c-n d / 4 . 0 /) ) .  \nBRIEF REPORT  \nSpontaneous Coronary Artery Menopausal Symptoms and  \nHormone Therapy Use in 661 Women  \nDissection  \nAshley E. Battenberg, BS,a Sharonne N. Hayes, MD,b Susan N. Kok, MD,c Stephanie S. Faubion, MD, MBA,d,e,f Marysia S. Tweet, MD, MSb  \nS  \npontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome of young and middle-aged women.1  \nEven though sex hormones are associated with SCAD, the pathogenesis is not well understood. As such, clinical decision-making for reproductive concerns is challenging. Furthermore, the average age of SCAD ranges from 45 to 53 years, which corresponds to when many women are perimenopausal.1 Current consensus is to avoid or minimize menopause hormone therapy (MHT) among SCAD patients; however, data regarding MHT use among this population are lacking.1 We aimed to quantify the burden of menopause symptoms in women with a history of SCAD and examine patterns of MHT use.  \nMETHODS  \nThis study received proper ethical oversight and was approved by the Mayo Clinic Institutional Review Board. We surveyed participants enrolled in the Mayo Clinic SCAD “Virtual” Multi-Center Registry, a prospective research cohort of individuals with angiographically confirmed SCAD. Of 1,617 total participants, 841 women completed key components of a supplemental survey addressing current menopause stage and symptoms over the past year.  \nPATIENT COHORT  \nA cohort of 661 (78.6%) self-reported as perimenopausal (105, 16.8%) or postmenopausal (spontaneously, 491, 74.3%, or by bilateral oophorectomy, 65, 9.8%) . Twenty-six (3.9%) women experienced early menopause between ages 40 and 44, and 4 (0.6%) experienced premature menopause under 40. The median patient-reported age at menopause was 51 (interquartile range [IQR]: 49-54), whereas the median age at first SCAD event was 50.6 (IQR: 44.8- 56.4) . The median age at the time of survey was 60.1 years (IQR: 55.9-68.1) .  \nSYMPTOM BURDEN  \nThe prevalence of menopause symptoms at the time of survey was substantial. Hot flashes and night sweats were reported by approximately half of respondents (52.6% and 53.1%, respectively, Figure 1), with over 20% of women experiencing these symptoms weekly or daily. Cognitive symptoms were also common: 60.0% of women reported memory concerns, and 85.6% reported poor sleep or insomnia. In addition, 152 (23.0%) reported either intentional or unintentional weight changes, the most common being unintentional weight gain (20.7%) .  \nFrom the aMayo Clinic Alix School of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; bDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; cDivision of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; dDivision of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Jacksonville, Florida, USA; eMayo Clinic Center for Women’s Health, Rochester, Minnesota, USA; and the fWomen’s Health Research Center, Mayo Clinic, Rochester, Minnesota, USA.  \nThe authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the Author Center.  \nISSN 2772-963X [https://doi.org/10.1016/j.jacadv.202","cbCaimRcP0QsLozm","https://ap.wps.com/l/cbCaimRcP0QsLozm","pdf",1036069,"English","# Methods\n## Patient cohort\n## Symptom burden\n## MHT patterns\n# Current knowledge and expert consensus on MHT safety after SCAD","[{\"question\":\"What was the study’s main objective regarding SCAD and menopause?\",\"answer\":\"To quantify the burden of menopause symptoms in women with a history of SCAD and to examine patterns of menopause hormone therapy (MHT) use.\"},{\"question\":\"How were participants recruited and how many were included in the analysis?\",\"answer\":\"Participants came from the Mayo Clinic SCAD “Virtual” Multi-Center Registry; 841 women completed key supplemental survey components, and the patient cohort analyzed included 661 women.\"},{\"question\":\"What proportion of women used systemic or local MHT in the survey?\",\"answer\":\"Systemic MHT was used by 48 women (7.3%), while local therapy (e.g., low-dose topical vaginal estrogen) was used by 76 women (11.5%); overall, 110 women (16.6%) used MHT either systemically or locally.\"}]","Spontaneous Coronary Artery Dissection - Menopausal Symptoms and Hormone Therapy Use in 661 Women | PDF",1790698020]