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This review analyzes sixteen case reports and discusses possible immune-linked mechanisms and future relevance for cancer therapy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/spontaneous-cancer-remission-after-covid-19-insights-from-the-pandemic-and-their-relevance-for-cancer-treatment/382294/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/spontaneous-cancer-remission-after-covid-19-insights-from-the-pandemic-and-their-relevance-for-cancer-treatment/382294.png","ImageObject",300,407,{"name":42,"@type":43},"Aria","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main focus of the review?","Question",{"text":63,"@type":64},"The review examines rare cases of spontaneous or prolonged cancer remission following COVID-19 infection or anti-SARS-CoV-2 vaccination and discusses potential mechanisms that may support cancer regression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How many case reports were reviewed?",{"text":68,"@type":64},"Sixteen case reports were reviewed: fourteen remission cases following viral infections and two after anti-SARS-CoV-2 vaccination.",{"name":70,"@type":61,"acceptedAnswer":71},"Why might COVID-19 immune responses be related to tumor regression?",{"text":72,"@type":64},"The document suggests that immune response to COVID-19 could be implicated in both tumor regression and progression, and it discusses mechanisms such as oncolytic and priming hypotheses.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},382294,1790295645,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Meo etal. Journal of Translational Medicine (2023) 21:273  \n[https://doi.org/10.1186/s12967-023-04110-w](https://doi.org/10.1186/s12967-023-04110-w)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nSpontaneous cancer remission  \nafter COVID-19: insights from the pandemic and their relevance for cancer treatment  \nConcetta Meo 1†, Giuseppe Palma2*†, Francesca Bruzzese2, Alfredo Budillon3, Claudio Napoli4,5† and Filomena de Nigris1*†  \nAbstract  \nEarly in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of COVID-19 disease in cancer patients, rare cases of temporary or prolonged clinical remission from cancers after SARS-CoV-2 infection have been reported. We have reviewed sixteen case reports of COVID-19 disease with spontaneous cancer reduction of progression. Fourteen cases of remission following viral infections and two after anti-SARS-CoV-2 vaccination. The immune response to COVID-19, may be implicated in both tumor regression, and progression. Specifically, we discuss potential mechanisms which include oncolytic and priming hypotheses, that may have contributed to the cancer regression in these cases and could be useful for future options in cancer treatment.  \n\n| †Concetta Meo and Giuseppe Palma are contribute equally |\n| --- |\n| †Claudio Napoli and Filomena de Nigris are contribute equally |\n\n*Correspondence:  \nGiuseppe Palma [giuseppe.palma@istitutotumori. na.it](giuseppe.palma@istitutotumori. na.it)[ ](giuseppe.palma@istitutotumori. na.it)Filomena de Nigris [filomena.denigris@unicampania.it](filomena.denigris@unicampania.it)  \n1 Department of Precision Medicine, School of Medicine, University of Campania“Luigi Vanvitelli”, Via De Crecchio 7, 80138 Naples, Italy  \n2 S. S. D. Sperimentazione Animale, Istituto Nazionale Tumori -IRCCSFondazione G. Pascale, Naples, Italy  \n3 Scientific Directorate-National Institute of Cancer-IRCCS-Fondazione  \nG. Pascale, Naples, Italy  \n4 Clinical Department of Internal Medicine and Specialistic Units, Division of Clinical Immunology and Immunohematology, Transfusion Medicine, and Transplant Immunology (SIMT), Azienda Universitaria Policlinico (AOU), 80138 Naples, Italy  \n5 Advanced Medical and Surgical Science (DAMSS), School of Medicine, University of Campania“Luigi Vanvitelli”, 80138 Naples, Italy  \nIntroduction  \nThe management of COVID-19 mortality in cancer patients is gradually improving, but many questions regarding the impact of COVID-19 on cancer remain. The Eastern Cooperative Oncology Group (ECOG) established that morbidity and mortality are greater in subjects with an ascertained COVID-19 diagnosis and cancer than in cancer free patients [1, 2]. In particular, lung cancer and hematological malignancies have poorer outcome following infection than other cancers [1–6]. This is probably due to a reduced respiratory capacity and more severe immune suppression in patients with these malignancies. Data linking oncologic treatment and cancer prognosis after COVID-19 remain difficult to evaluate. Complicating factors include the various treatment regimens for both cancer and COVID-19, the temporal relationship between cancer stages and COVID-19 exposure, and patient-specific confounders. However, despite the lethality of malignant tumors and increased risk following COVID-19 some spontaneous  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the arti","cbCail1YFnKtwMBZ","https://ap.wps.com/l/cbCail1YFnKtwMBZ","pdf",1422044,13,"English","# Abstract\n# Introduction","[{\"question\":\"What is the main focus of the review?\",\"answer\":\"The review examines rare cases of spontaneous or prolonged cancer remission following COVID-19 infection or anti-SARS-CoV-2 vaccination and discusses potential mechanisms that may support cancer regression.\"},{\"question\":\"How many case reports were reviewed?\",\"answer\":\"Sixteen case reports were reviewed: fourteen remission cases following viral infections and two after anti-SARS-CoV-2 vaccination.\"},{\"question\":\"Why might COVID-19 immune responses be related to tumor regression?\",\"answer\":\"The document suggests that immune response to COVID-19 could be implicated in both tumor regression and progression, and it discusses mechanisms such as oncolytic and priming hypotheses.\"}]","Spontaneous cancer remission after COVID-19 - insights from the pandemic and their relevance for cancer treatment | PDF",1790249914,33]